Clinical trials: Prostatectomy
Prostate Cancer, Prostatectomy
Study of Sunitinib Malate in Patients With Newly Diagnosed Prostate Cancer Prior to Prostatectomy
The purpose of this study is to look at blood and tissue samples for changes following the use of Sunitinib malate. Additionally, we would like to find out if the drug, Sunitinib malate, is safe and works in men with prostate…
- Trial name
- NCT00672594
- Testing
- Sunitinib Malate
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Prostate Cancer
Nerve-sparing, Robot-assisted Radical Prostatectomy Using a Personalized, 3D-printed Prostate Model for Selective Resection of Positive Surgical Margins
To optimize precision for secondary resection (SR) in frozen section (FS) controlled nerve-sparing robot-assisted radical prostatectomy (NS-RARP) by using a personalized 3D-printed prostate model.
- Trial name
- AURORA (NCT05960669)
- Testing
- 3D model guided secondary resection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Prostate Cancer
Study to Evaluate a New Method to Detect Residual Tumours During Surgery for Prostate Cancer Using Confocal Microscopy
Prostate cancer is the most common solid cancer affecting male patients worldwide. When diagnosed early, it can usually be cured with surgery (radical prostatectomy), but this procedure is associated with side effects such as…
- Trial name
- NCT06398470
- Testing
- NeuroSAFE procedure, LaserSAFE procedure
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University College, London
Prostate Cancer
Salvage Stereotactic Body Radiotherapy of the Prostate Bed for Biochemical Recurrence After Radical Prostatectomy.
This is a a randomized phase II/III trial comparing salvage SBRT with standard of care (SOC) regimens for patients with a persistent detectable PSA or biochemical progression during follow-up after radical prostatectomy.
- Trial name
- STEREOBED (NCT06523634)
- Testing
- Stereotactic body radiotherapy (SBRT), SOC RT
- Where
- 13 sites in Belgium
- Volunteers
- 284 people
- Sponsor
- Jules Bordet Institute
Prostatic Diseases, Genital Neoplasms, Male
A Study of Ixabepilone Before Surgery for High-Risk Localized Prostate Cancer
The purpose of this research study is to determine the safety and effectiveness of the investigational drug, Ixabepilone, in men with high risk prostate cancer who plan to receive surgery.
- Conditions
- Prostatic Diseases, Genital Neoplasms, Male, Urogenital Neoplasms, Genital Diseases, Male
- Trial name
- NCT00672009
- Testing
- Ixabepilone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer
Neoadjuvant Ipilimumab in Prostate Cancer
The goal of this clinical research study is to learn how ipilimumab in combination with Lupron (leuprolide acetate) affects the body's own defense (immune) system before having surgery to remove prostate cancer.
- Trial name
- NCT01194271
- Testing
- Leuprolide Acetate, Ipilimumab, Radical Prostatectomy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Prostate Cancer
Lidocaine Combined With Sufentanil for Preventing Catheter-related Bladder Discomfort
The goal of this clinical trial is to evaluate the incidence and severity of postoperative catheter-related bladder discomfort after robot-assisted radical prostatectomy.
- Trial name
- NCT05957653
- Testing
- lidocaine and sufentanil, Saline
- Volunteers
- 140 people
- Sponsor
- RenJi Hospital
Prostate Cancer, Prostate Adenocarcinoma
Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer
This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate cancer who have negative or equivocal findings on conventional imaging.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Recurrent, Prostate Cancer Metastatic
- Trial name
- CONDOR (NCT03739684)
- Testing
- 18F-DCFPyL, PET/CT Imaging
- Where
- 14 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Progenics Pharmaceuticals, Inc.
Prostate Cancer
Ferumoxytol Enhanced MRI for the Detection of Lymph Node Involvement in Prostate Cancer
Background: Ferumoxytol is an approved iron replacement therapy agent that has some potential for use as a contrast agent in imaging studies of the lymph system, especially involving lymph nodes that have been affected by cancer.
- Trial name
- NCT01296139
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Prostatic Neoplasms
Atorvastatin Before Prostatectomy and Prostate Cancer
This single-center, randomized, double-blind trial assesses the impact of short-term atorvastatin administration on proliferation activity, apoptotic rate and histological inflammation in prostate tissue.
- Trial name
- ESTO1 (NCT01821404)
- Testing
- Atorvastatin
- Where
- 3 sites in Finland
- Volunteers
- 160 people
- Sponsor
- Tampere University Hospital
Erectile Dysfunction
Research Evaluating an Investigational Medication for Erectile Dysfunction - Post-Prostatectomy
The objectives of this study are to evaluate the safety and efficacy of two doses of avanafil in the treatment of adult males for erectile dysfunction following bilateral nerve-sparing radical prostatectomy.
- Trial name
- NCT00895011
- Testing
- Avanafil
- Where
- 51 sites in United States
- Volunteers
- 298 people
- Sponsor
- VIVUS LLC
Prostatectomy
Prospective Clinical Study of the Levita Magnetics Surgical System Used for Prostatectomy Surgery
The purpose of this study is to evaluate the safety and effectiveness of the Levita Magnetic Surgical System in patients undergoing prostatectomy surgery.
- Trial name
- NCT03624465
- Testing
- Levita Magnetic Surgical System
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Levita Magnetics
Prostate Cancer
Development and Evaluation of a Therapeutic Education Intervention in Prostate Cancer Patients Treated With Radical Prostatectomy to Improve Their Sexuality
Prostate cancer is the most common cancer in France (54,000 cases in 2011). About 20,000 radical prostatectomies (PR) per year are performed.
- Trial name
- PRODUCAN (NCT03572621)
- Testing
- Therapeutic education, Collection of data concerning their sexuality, Participation
- Where
- 2 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer
The Impact of Low Pressure Pneumo in RARP
The purpose of this study is to evaluate clinical significance of low pressure pneumoperitoneum during robotically assisted radical prostatectomy (RARP).
- Trial name
- NCT03370016
- Testing
- Amount of Pneumoperitoneum Pressure applied during RARP
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Metro Health, Michigan
Prostate Cancer
Prostatectomy Prospective Database
The purpose of establishing the database is to evaluate the effects of surgical removal of the prostate (prostatectomy) and cryosurgery on prostate cancer, quality of life, and overall health.
- Trial name
- NCT00447616
- Where
- United States
- Volunteers
- 896 people
- Sponsor
- Kenneth Peters, MD
Erectile Dysfunction Following Radical Prostatectomy
The Use of Bioelectrical Stimulation in the Treatment of Post-prostatectomy Erectile Dysfunction
Erectile dysfunction (ED) affects up to 20% of men and is a growing problem with advancing age. There are many causes that contribute to ED, including the concomitant use of prescription drugs for health problems, including…
- Trial name
- NCT05118607
- Testing
- IG1
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Prostate Cancer
Calcitriol and Dexamethasone Before Radical Prostatectomy in Treating Patients With Localized Adenocarcinoma (Cancer) of the Prostate
RATIONALE: Calcitriol and dexamethasone may slow the growth of prostate cancer cells. PURPOSE: This randomized phase II trial is studying how well giving calcitriol together with dexamethasone before radical prostatectomy works…
- Trial name
- NCT00084864
- Testing
- calcitriol, dexamethasone, clinical observation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Roswell Park Cancer Institute
Prostatectomy, Prostate Neoplasm
The Robot-Assisted Laparoscopic Radical Prostatectomy Combined Anterior and Posterior Approach
The goal of this observational study was to compare the perioperative outcomes, postoperative urinary control rates and positive surgical margin (PSM) rates of the robot-assisted laparoscopic radical prostatectomy combined…
- Trial name
- NCT06020287
- Testing
- the robot-assisted laparoscopic radical prostatectomy
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Nanjing University School of Medicine
Prostate Cancer (Post Prostatectomy), Urinary Continence
Analysis of Immediate Urinary Continence Predictors After RS-RARP
This study is a retrospective, single-center clinical trial. It aims to retrospectively analyze the immediate postoperative urinary continence recovery in prostate cancer patients who underwent Retzius-sparing robot-assisted…
- Conditions
- Prostate Cancer (Post Prostatectomy), Urinary Continence, Retzius-sparing Robot-assisted Radical Prostatectomy
- Trial name
- NCT06850116
- Testing
- Retzius-sparing robot-assisted radical prostatectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University