Clinical trials: Prostatic Disease
Prostate Cancer
Two-Dose Level Evaluation of NX-1207 for the Treatment of Low Risk, Localized (T1c) Prostate Cancer
This study is designed to evaluate the safety and efficacy of a single injection of NX-1207 for the treatment of biopsy-confirmed low risk localized (T1c) prostate cancer in patients currently undergoing active surveillance.
- Trial name
- NCT01620515
- Testing
- NX-1207 2.5 mg, NX-1207 15 mg
- Where
- 23 sites in United States
- Volunteers
- 141 people
- Sponsor
- Nymox Corporation
Prostate Cancer
Prospective Multicentre Cohort Study PROREPAIR-B (mCRPC)
PROREPAIR is a prospective multicenter observational cohort study of unselected patients with metastatic Castration Resistant Prostate Cancer (mCRPC) with unknown germline mutational status at study entry and who are candidates…
- Trial name
- NCT03075735
- Volunteers
- 408 people
- Sponsor
- Centro Nacional de Investigaciones Oncologicas CARLOS III
Prostate Cancer
A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer
The primary purpose of this study is to evaluate the ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response.
- Trial name
- NCT00186108
- Testing
- Oral Triamcinalone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm
A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer
This phase II trial tests the how well a precision medicine approach (serial measurements of molecular and architectural response to therapy [SMMART])-adaptive clinical treatment [ACT]) works in treating patients with sarcoma…
- Conditions
- Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma, Advanced Pancreatic Carcinoma
- Trial name
- NCT06630325
- Testing
- Abemaciclib, Biopsy, Bone Scan
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OHSU Knight Cancer Institute
Prostate Cancer
Markers for Early Detection of Prostate Cancer
This study will determine whether certain gene alterations can serve as markers for early detection of prostate cancer. Prostate cancer is often diagnosed by detecting high levels of a protein called prostate-specific antigen…
- Trial name
- NCT00340717
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Financial Toxicity, Cancer
DISCO: A Patient Intervention to Reduce the Financial Burden of Cancer
The DISCO App is designed to improve, during the interaction, patient active participation and patient-initiated oncologist treatment cost discussions, and, in the short term, patient's treatment cost knowledge, self-efficacy for…
- Conditions
- Financial Toxicity, Cancer, Question Prompt List, Breast Cancer
- Trial name
- DISCO (NCT04766190)
- Testing
- Group 2: The DISCO App, Group 1: Usual Care, Group 3: The DISCO App + Booster
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Lauren Hamel
Prostate Cancer
Race-related Alternative Splicing: Novel Targets in Prostate Cancer
Data from evaluating prostate cancer (PCa) biopsy tissue from AA and white patients has led to the discovery of alternative splicing as a novel molecular mechanism underlying more aggressive PCa in AA men.
- Trial name
- PCaP splicing (NCT03424213)
- Testing
- No interventions - retrospective data collection
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Duke University
Prostate Cancer
Soy Derivatives for Control of Hot Flashes in Men on Androgen Deprivation Therapy
To determine the efficacy of soy/isoflavone supplementation on hot flashes in men who are being treated with luteinizing hormone-releasing hormone (LHRH) agonist therapy for control of advanced prostate cancer
- Trial name
- NCT00594620
- Testing
- Flav-ein capsules
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Kansas Medical Center
Prostate Cancer
Volume Controlled Ventilation vs Autoflow-volume Controlled Ventilation
Volume controlled ventilation(VCV) is a most common used ventilation mode during general anesthesia. But VCV can cause high airway peak pressure when patient under steep Trendelenberg position with pneumoperitoneum.
- Trial name
- VCVAFVCV (NCT02512120)
- Testing
- volume controlled ventilation, autoflow-volume controlled ventilation
- Sponsor
- Korea University Anam Hospital
Prostatic Hyperplasia
FLOMAX® Versus HYTRIN® in Patients With the Signs and Symptoms of Benign Prostatic Hyperplasia
1. To study the early onset of symptomatic relief afforded by FLOMAX® capsules, 0.4 mg daily as compared to HYTRIN® capsules, 5 mg (with titration) daily in patients with the signs and symptoms of benign prostatic hyperplasia…
- Trial name
- NCT02244255
- Testing
- FLOMAX® capsules, Ascending doses of HYTRIN® capsules
- Volunteers
- 1,993 people
- Sponsor
- Boehringer Ingelheim
Benign Prostatic Hyperplasia
Study of the Effects of Pomegranate Tablets on Enlarged Prostates
To determine whether pomegranate tablets have a therapeutic effect on Benign Prostatic Hyperplasia.
- Trial name
- NCT00381108
- Testing
- Pomegranate Tablet
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Prostatic Neoplasm
Efficacy and Safety of a Triptorelin 6-month Formulation in Patients With Advanced Prostate Cancer
Efficacy and safety of a triptorelin 6-month formulation in patients with advanced prostate cancer. It was assumed that during the study treatment >90% of the patients would achieve and maintain castrate levels of serum…
- Trial name
- NCT00751790
- Testing
- triptorelin embonate (INN)
- Where
- South Africa
- Volunteers
- 120 people
- Sponsor
- Debiopharm International SA
Prostate Cancer
Novel PET/CT Agents and MRS/MRI in Prostate CA and High Risk Prostate Cancer: An Inter-SPORE Collaboration
Prostate cancer imaging using traditional anatomic modalities including CT, MR, and ultrasound is limited. Improvement in current imaging modalities or development of new ones should be a priority in prostate cancer research.
- Trial name
- NCT00987376
- Testing
- Diagnostic Imaging: C11 choline PET; C11 acetate PET; and MRI Spectroscopy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Urinary Retention
Use of The Spanner Temporary Prostatic Stent as an Alternative to a Urinary Catheter to Achieve Bladder Drainage in Men
The Spanner is being evaluated for use to manage voiding dysfunction and lower urinary tract symptoms in subjects to achieve bladder drainage in men unfit for other treatments.
- Trial name
- NCT02643849
- Testing
- The Spanner Temporary Prostatic Stent
- Where
- 6 sites in United States
- Volunteers
- 107 people
- Sponsor
- SRS Medical
Prostate Cancer
Multi-peptide Vaccination and Bispecific PSMAxCD3 Antibody Treatment in Patients With Prostate Cancer
This trial is a phase II, randomized, open label study designed to evaluate safety, tolerability and efficacy of CC-1, a bispecific antibody (bsAb) with PSMAxCD3 specificity, and of VACXS15-PC01, a prostate cancer (PC)-specific…
- Trial name
- ImmProCure (NCT07860047)
- Testing
- PSMAxCD3, bispecific antibody CC-1, Multipeptide Vaccine VAC-XS15-PC01
- Where
- 4 sites in Germany
- Volunteers
- 84 people
- Sponsor
- University Hospital Tuebingen
Prostate Cancer, Prostate Neoplasm
Reducing Sedentary Behavior Among Prostate Cancer Survivors on Androgen Deprivation Therapy
The current study aimed to develop and assess an easy-to-use, highly accessible mobile and web-based application intervention to reduce sedentary behavior and increase physical activity in the hope of reducing the side effects of…
- Conditions
- Prostate Cancer, Prostate Neoplasm, Cancer, Sedentary Lifestyle
- Trial name
- RiseTx (NCT03321149)
- Testing
- RiseTx
- Volunteers
- 46 people
- Sponsor
- University of Illinois at Urbana-Champaign
Prostate Cancer
MRI-guided Ultrahypofractionated SBRT Prostate Program
The goal of this clinical trial is to learn if the use of MRI-guided asymmetric ultrahipofractionated irradiation (2 fractions with dose increase in the tumor areas and dose sparing in urethra, rectum and neurovascular bundles)…
- Trial name
- NCT07132658
- Testing
- MR-Guided SBRT
- Volunteers
- 40 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Prostate Cancer
A Study of Imatinib and Docetaxel in Prostate Cancer
The purpose of this study is to determine the effectiveness of two drugs, docetaxel and Gleevec®(also called imatinib), in prostate cancer that no longer responds to hormone therapy.
- Trial name
- NCT00251225
- Testing
- Gleevec, Docetaxel
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Leonard Appleman
Benign Prostatic Hyperplasia
Protocollo N 2014 - Benign Prostatic Hyperplasia
Prospective observational study on the quality of life of patients with BPH under medical therapy and/or undergoing surgery.
- Trial name
- NCT06182189
- Testing
- Observation of patients with a benign prostatic hyperplasia condition
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- IRCCS San Raffaele
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy
Subjects will be randomized into 2 groups (stent or no stent) prior to radical cystectomy with ileal conduit urinary diversion (RCIC). They will follow the standard of care and be enrolled in the study for 12 months post-op.
- Conditions
- Bladder Cancer, Muscle-Invasive Bladder Carcinoma, Urothelial Carcinoma, Pelvic Malignancy
- Trial name
- NCT07234968
- Testing
- Ureteral Stent Placement, No Ureteral Stent, Indocyanine Green with Fluorescence Imaging
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
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