Clinical trials: Prosthesis
Orthoses, Prostheses
Hand Assistive Rehabilitation Orthotic Device Effectiveness Study
The primary objective of this study is to evaluate pinch strength improvements and improvements in coordination and functional ability.
- Trial name
- NCT04565639
- Testing
- Powered Hand Orthosis
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Amputees
Evaluation of a Multimodal Tactile Feedback System for Upper Limb-loss Users: Embodiment and Performance
The aim of this study is to evaluate the effect of integrating tactile feedback systems into a robotic upper-limb prosthesis. These systems deliver pressure stimuli (through small silicone chambers that inflate), vibration…
- Trial name
- THE_FBHAND (NCT07418645)
- Testing
- Pressure and vibrotactile feedbak, Pressure feedback, Vibrotactile feedback
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- University of Pisa
Aortic Valve Stenosis
5 Year Observation of Patients With PORTICO Valves
The purpose of this clinical investigation is to further assess the performance and safety profile of the commercially-available Portico™ TAVI System in patients with severe symptomatic aortic stenosis.
- Trial name
- PORTICO-1 (NCT01802788)
- Testing
- St Jude Medical Portico replacement aortic valve, Transcatheter Aortic Valve Implant
- Where
- 60 sites in Australia, Belgium and 11 more
- Volunteers
- 1,032 people
- Sponsor
- Abbott Medical Devices
Amputation, Artificial Limbs
Kinematic, Kinetic, and Metabolic Comparison of Bilateral Transfemoral Ambulation With Passive Versus Powered Prosthetic Devices
The purpose of this descriptive and exploratory pilot study is to investigate: (1) sagittal plane hip kinematics and kinetics and (2) metabolic consumption/cost, for bilateral transfemoral walking with passive prostheses versus…
- Conditions
- Amputation, Artificial Limbs, Energy Expenditure, Kinetics
- Trial name
- NCT02366702
- Testing
- Lower Limb Powered Knee-Ankle Prosthesis
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Southern California Institute for Research and Education
Gingivitis, Periodontal Disease
Touch-to-Teach Interdental Brush Instruction Versus Conventional Guidance on Gingival Health in Patients With Fixed Dental Prostheses
Why is this study being done? People with dental crowns often develop inflamed gums because bacteria accumulate in the tight spaces between teeth that a regular toothbrush cannot reach.
- Conditions
- Gingivitis, Periodontal Disease, Fixed Dental Prosthesis, Dental Plaque
- Trial name
- NCT07636954
- Testing
- Touch-to-Teach interdental brush instruction, Conventional oral hygiene instruction
- Where
- United Arab Emirates
- Volunteers
- 32 people
- Sponsor
- Gulf Medical University
Osteoarthritis, Knee, Prosthesis User
Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis
Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage.
- Trial name
- MEDADIPO (NCT03678831)
- Testing
- tissue
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Lille
Lung Neoplasm, Carcinoma, Non-Small-Cell Lung
Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers
A tumoral obstruction of the main stem bronchus is frequently observed in the follow-up of lung cancers with a high impact on survival and quality of life of these patients.
- Trial name
- SPOC (NCT01064050)
- Testing
- silicone trachea-bronchial stent Dumon (Novatech)
- Where
- 13 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction
Randomized Evaluation for Failed TAVR
REVIVE TAVR is an acronym for the Randomized Evaluation of Valve-In-Valve versus Explantation for failed TAVR. This is a prospective, multicenter, global randomized trial investigating the safety and efficacy of reintervention…
- Conditions
- Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure
- Trial name
- REVIVE-TAVR (NCT06400342)
- Testing
- TAVR-explant, Redo-TAVR
- Volunteers
- 264 people
- Sponsor
- Medstar Health Research Institute
Total Knee Arthroplasty
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
The life expectancy worldwide is increasing and leading to an increase of knee arthroplasty. Also, as millions of people around the world are currently living with a Total Knee Arthroplasty (TKA), the need for revision surgery…
- Trial name
- FHK-CK (NCT06124482)
- Testing
- Total Knee arthroplasty
- Where
- 7 sites in France
- Volunteers
- 92 people
- Sponsor
- FH ORTHO
Esophageal Neoplasms, Dysphagia
Comparative Study Between (FC-SEMS) and (PC-SEMS) in the Palliation of Dysphagia Due to Malignant Neoplasm of Esophagus.
Esophageal cancer is the seventh most common type of cancer in the world, with an estimated global incidence of 604,100 new cases per year. The main symptom of esophageal cancer is dysphagia, associated or not with weight loss.
- Trial name
- NCT06070376
- Testing
- Fully Covered Esophageal Prosthesis (FC-SEMS), Partially Covered Esophageal Prosthesis (PC-SEMS)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Amputation
Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees
The purpose of this study is to develop a robust, low-power, stable, and light weight, active knee prosthetic device that can dramatically increase gait symmetry and walking economy of a transfemoral amputee during walking.
- Trial name
- NCT00771589
- Testing
- Active Knee Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Providence VA Medical Center
Prosthesis and Implant Dentistry
Passive Fit of Implant-Supported Complete-Arch Prostheses Using Digital Workflows
The goal of this clinical trial is to evaluate and compare three digital workflows for the fabrication of definitive implant-supported full-arch prostheses in adult patients requiring fixed implant rehabilitation.
- Trial name
- MFS03-Pdental (NCT07315620)
- Testing
- CBCT-STL Alignment Workflow, Splint-Guided Alignment Workflow, Automated AI-Assisted CBCT-STL Alignment Workflow
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Breast Augmentation, Breast Reconstruction
Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial
The Contour Profile Gel Study is designed to demonstrate safety and effectiveness of Mentor's Mammary Prostheses in women who are undergoing primary augmentation, primary reconstruction, or revision.
- Conditions
- Breast Augmentation, Breast Reconstruction, Breast Revision
- Trial name
- CPG (NCT00812097)
- Testing
- Mentor Siltex® Contour Profile Gel Mammary Prosthesis
- Where
- United States
- Volunteers
- 955 people
- Sponsor
- Mentor Worldwide, LLC
Osteoarthritis, Knee
GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs
Unicompartmental knee arthroplasty (UKA) is the principal surgical alternative to the total knee arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Trial name
- NCT03522025
- Testing
- Unicompartmental Knee Arthroplasty (UKA)
- Where
- 5 sites in France, Switzerland
- Volunteers
- 70 people
- Sponsor
- Medacta International SA
Amputation
Evaluation of Satisfaction and Effect on Daily Living Activities With the Use of Myoelectric Controlled Prosthesis
Myoelectrically controlled arm prostheses are often offered to individuals with upper extremity limb loss in order to restore body balance and compensate for the lack of grasping ability during the rehabilitation process.
- Trial name
- NCT05261178
- Testing
- Evaluation of satisfaction and the level of daily living activities using the prosthesis
- Volunteers
- 20 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Jaw, Edentulous, Partially
Comparison Between Cobalt-chromium Partial Dentures and Thermoplastic Partial Dentures
The cobalt-chromium (CoCr) partial denture has been made for a long period. It respects biomechanical principles, providing harmony between mechanical and biological activities.
- Trial name
- Flex (NCT01816425)
- Testing
- Thermoplastic partial denture, CoCr partial denture
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Osteoarthritis, Hip, Hip Osteoarthritis
Clinical and Functional Outcome of the MobileLink Acetabular Cup System in the Short-, Mid-, and Longterm Follow-up
The implantation of artificial hip joints is one of the most frequently performed surgeries. Normally, patients are very satisfied with the results. The MobileLink hip prosthesis system is a CE marked medical device.
- Conditions
- Osteoarthritis, Hip, Hip Osteoarthritis, Prosthesis Survival, Prosthesis Failure
- Trial name
- NCT04688593
- Testing
- MobileLink
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 520 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Amputation
Clinical Trial of Tensegrity Prosthetics K3 Promoter Foot Prosthesis
The purpose of this clinical trial is to determine if the experimental Tensegrity prosthetic foot offers a reduction of the amount of oxygen used while walking, if stability is improved over current prosthetic feet, and whether…
- Trial name
- NCT00888199
- Testing
- Experimental prosthetic foot (K3 Promoter)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tensegrity Prosthetics
THA, Prosthesis
A Prospective Multicenter Clinical Study on the Efficacy and Safety of the Zirconia Ceramic Hip Joint Prosthesis System After Its Market Launch
This study adopted a prospective, multi-center, single-group target value trial design to evaluate the safety and efficacy of the hip joint prosthesis system produced by Beijing Anshou Technology Co., Ltd.
- Trial name
- NCT07382050
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Peking University Third Hospital
Aortic Regurgitation Disease, Aortic Valve Calcification
Valvular Assessment of New Generation Aortic Replacement Devices
The VANGUARD study is an open-label, prospective, randomized trial comparing the long-term outcomes of two advanced bioprosthetic aortic valves, Dafodil® and INSPIRIS Resilia®, in patients undergoing aortic valve replacement…
- Conditions
- Aortic Regurgitation Disease, Aortic Valve Calcification, Bicuspid Aortic Valve Disease
- Trial name
- VANGUARD (NCT06688448)
- Testing
- Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia