Clinical trials: Prosthesis, open to volunteers
Rheumatoid Arthritis, Arthritis of Ankle
Vantage Mobile Bearing Total Ankle System Post Market Clinical Follow-up (Outside US)
The objectives of this study are to evaluate the performance and safety of the Vantage Mobile-Bearing Total Angle System. This study will follow subjects for a period of up to 10 years post-surgery.
- Conditions
- Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
- Trial name
- NCT05691868
- Where
- 2 sites in Spain, Switzerland
- Volunteers
- 400 people
- Sponsor
- Exactech
Upper Extremity Amputee
Peripheral Interfaces in Amputees for Sensorimotor Integration
The purpose of this research is to gather information on the safety and effectiveness of an implanted wireless sensory enabled highly intuitive controlled prosthetic device.
- Trial name
- iSens (NCT04430218)
- Testing
- iSens
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Accuracy of Dynamic Navigation System in Implant Placement for Full Arch Prosthesis Rehabilitation
Evaluating the Accuracy of Dynamic Navigation in Implant Surgery for Full Arch Prosthesis
Study Objective: This study aims to evaluate the accuracy of the Dynamic Navigation System in performing implant placement for full arch prosthesis rehabilitation.
- Trial name
- NCT06963242
- Testing
- Dynamic Navigation System for Implant Placement Using Bone Screws as Landmarks, Dynamic Navigation System for Implant Placement Using Remaining Teeth as Landmarks
- Where
- 2 sites in Vietnam
- Volunteers
- 12 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Amputation, Amputation, Traumatic
Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control
The goal of this clinical trial is to systematically evaluate whether or not two commonly held fundamental assumptions for pattern recognition control translates to functional performance when tested on individuals aged 18 years…
- Conditions
- Amputation, Amputation, Traumatic, Amputation, Congenital, Prosthesis User
- Trial name
- NCT07011420
- Testing
- Experimental socket with 4 untargeted channels active, Experimental socket with 8 untargeted channels active, Experimental socket with up to 16 untargeted channels active
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Liberating Technologies, Inc.
Hip Arthropathy Associated With Other Conditions, Hip Dysplasia
Long-term Survival of THA After Pelvic and/or Femoral Osteotomy
Analyze the long-term clinical and radiological outcomes of total hip arthroplasty (THA) in patients with hip dysplasia treated by pelvic osteotomy, femoral osteotomy, shelf acetabuloplasty, or a combination of these…
- Conditions
- Hip Arthropathy Associated With Other Conditions, Hip Dysplasia, Survival, Prosthesis
- Trial name
- NCT06959498
- Testing
- Total hip arthroplasty
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Alzheimer's Dementia (AD)
AMPER Proof of Concept Study
The AMPER (Agent-based Memory Prosthesis to Encourage Reminiscing) system has been built to help people with Alzheimer's disease by improving their memory recall and quality of life.
- Trial name
- AMPER (NCT06894953)
- Testing
- Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER), Non-Personalised Agent-based Memory Prosthesis to Encourage Reminiscing (AMPER)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Strathclyde
Chest Wall Tumors, Post-traumatic Syndrome
"Multicenter Registry for Chest Wall Reconstruction Using Custom Dynamic Prostheses (PRODIPET)"
PRODIPET Study Summary Title: Multicenter Registry for Chest Wall Reconstruction Using Custom 3D-Printed Titanium Prostheses Purpose The PRODIPET study evaluates the safety and effectiveness of personalized, dynamic titanium…
- Conditions
- Chest Wall Tumors, Post-traumatic Syndrome, Malignant Bone Tumor of Chest Wall
- Trial name
- PRODIPET (NCT07018960)
- Testing
- Chest wall reconstruction with 3D printed titan custom prothesis
- Where
- 5 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Localized Prostate Adenocarcinoma
Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately…
- Trial name
- HIP-PRO (NCT07042256)
- Testing
- Low-field MR-informed adaptive marker-less SBRT for definitive treatment of localized prostate cancer in patients with bilateral hip prostheses
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- University of Zurich
Amputation of Lower Limb
Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss
The goal of clinical trial is to assess an integrated, patient-centered strategy combining user preference-based prosthetic foot prescription and subsequent targeted physical therapy to maximize satisfaction and mobility outcomes…
- Trial name
- OPORP (NCT06844305)
- Testing
- Prosthetic foot, Physical therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwestern University
Knee Prosthesis
Study of the Prognostic Value of the Coagulolytic Balance Dependent on Circulating Microvesicles in the Occurrence of Thrombotic Events After Total Knee Replacement in Orthopedic Surgery.
This is a prospective multicenter cohort study to evaluate the prognostic value of new biological markers in predicting thrombotic events after orthopedic surgery.
- Trial name
- MOTiVE (NCT05387694)
- Testing
- Thrombotic risk assessment
- Where
- France
- Volunteers
- 387 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Erectile Dysfunction (ED)
IPP Placement & Intracavernosal Block
The inflatable penile prosthesis (IPP) is the gold standard for surgical management of erectile dysfunction (ED) and there is no consensus on the best postoperative pain management regimen.
- Trial name
- IPP (NCT07246642)
- Testing
- Exparel/bupivacaine mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff
Comprehensive Reverse Shoulder Data Collection
This study is a multicenter, prospective, non-randomized, non-controlled clinical outcome study. The primary objective of this study is to evaluate improvement of pain score at one year for the Biomet Comprehensive Reverse…
- Conditions
- Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects
- Trial name
- NCT03404778
- Testing
- Biomet Comprehensive Reverse Shoulder
- Where
- 4 sites in United States
- Volunteers
- 175 people
- Sponsor
- Zimmer Biomet
Arthritis Shoulder
Anatomic TSA vs RTSA for Glenohumeral Arthritis
There are no published prospective studies that compared 2-year functional outcomes of RTSA and anatomic TSA for the treatment of primary glenohumeral osteoarthritis with intact rotator cuffs and no excessive glenoid…
- Trial name
- NCT04629391
- Testing
- Total shoulder arthroplasty
- Where
- Switzerland
- Volunteers
- 296 people
- Sponsor
- La Tour Hospital
Prosthesis Survival, Arthropathy of Knee
Evaluation of 5-year Survival and Clinical Outcomes in Patients Undergoing Total Knee Arthroplasty With a Polyethylene Tibial Component
Total knee arthroplasty (TKA) is one of the most successful procedures in orthopedic surgery for treating advanced knee osteoarthritis, providing pain relief, functional recovery, and improved quality of life.
- Trial name
- ALLPOLY-TKA (NCT07544264)
- Testing
- Total knee arthroplasty
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Caesar Foot Take-Home Validation Testing
The rationale for this study is to conduct a take-home clinical trial to evaluate the impact of the bimodal Caesar foot in a real-world environment.
- Trial name
- NCT07075198
- Testing
- Caesar Foot
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Liberating Technologies, Inc.
Transfemoral Amputation, Limb Loss
Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators
Microprocessor-controlled knees (MPKs) automatically adjust resistance or damping in the joint to improve swing- and/or stance-phase control as appropriate for the prosthesis user during gait.
- Conditions
- Transfemoral Amputation, Limb Loss, Limb Absence
- Trial name
- MPK-K2 (NCT07103798)
- Testing
- College Park ICON, Conventional NMPK
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Amputation, Prosthesis User
Sonomyographic Upper Limb Prosthetics: A New Paradigm
The vast majority of all trauma-related amputations in the United States involve the upper limbs. Approximately half of those individuals who receive a upper extremity myoelectric prosthesis eventually abandon use of the system…
- Trial name
- NCT05376332
- Testing
- Sonomyographic Prosthesis, Myoelectric direct control prosthesis, Myoelectric pattern recognition prosthesis
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- George Mason University
Accuracy of Artificial Intelligence in Fixed Dental Prosthesis Design
Artificial Intelligence Versus Conventional Digital Design for Fixed Dental Prosthesis
This in vitro study aims to evaluate the accuracy of an Artificial Intelligence (AI)-based automatic design system for fixed dental prosthesis (FDP) compared with conventional computer-aided design (CAD) software.
- Trial name
- NCT07432165
- Testing
- Conventional CAD-Based Fixed Dental Prosthesis Design, Artificial Intelligence-Based Fixed Dental Prosthesis Design
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- October University for Modern Sciences and Arts
Nipple-sparing Mastectomy, Immediate Prosthesis Reconstruction
Endoscopic and Robotic NSM with Immediate Prosthesis Breast Reconstruction
Breast cancer is the most common malignant tumor in women. Surgical treatment is the most important treatment for early breast cancer. Breast cancer resection is considered to be a destructive operation.
- Conditions
- Nipple-sparing Mastectomy, Immediate Prosthesis Reconstruction, Endoscopic Surgery, Robotic Surgery
- Trial name
- EnRoNSM (NCT06748677)
- Where
- China
- Volunteers
- 484 people
- Sponsor
- Peking University People's Hospital
Amputation
Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations
Veterans with below-knee amputations are limited by prosthetic feet that cannot adapt to sloped and uneven terrain. This limitation results in reduced mobility, reduced balance confidence, and a higher risk of falls among some…
- Trial name
- NCT07266077
- Testing
- Fillauer Slope Adaptive Foot, Fillauer Motion Foot SLX
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development