Clinical trials: Prosthetic
Staphylococcal Infections
Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection
To determine the outcome and safety of a combined antimicrobial treatment involving daptomycin and surgical approach involving retention or short-interval two-stage exchange of the implant.
- Trial name
- Dapto-Studie (NCT01144000)
- Testing
- Daptomycin
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Andrej Trampuz
Vascular Access for Hemodialysis and Inflammation
Vascular Access for Hemodialysis and Inflammation
The aim of the present study was to investigate patients free of active infection and/or thrombosis to assess if the type of vascular access (AVF, AVG, TCC), could influence: 1.
- Trial name
- NCT00850707
- Where
- Italy
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Femoral Neck Fractures, Prosthetic Infection
Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture
Rational for conducting the study: Periprosthetic joint infection (PJI) is the most feared complication following prosthetic replacement of the hip joint and is associated with increased mortality, morbidity and economic burden.
- Trial name
- DAICY (NCT05164081)
- Testing
- antibiotic loaded bone cement (gentamicin+clindamycin) COPAL G+C (Heraeus)., antibiotic loaded bone cement (gentamicin) Paladins R+G (Heraeus) or Refobacin (Biomet).
- Where
- Sweden
- Volunteers
- 7,000 people
- Sponsor
- Umeå University
Prosthetic Joint Infections
Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy
On joint orthopaedic hardware infections are one of the most frequently encountered complications in orthopaedic surgery. However 6% of the cultures remain sterile, etiological diagnosis cannot be established despite obvious…
- Trial name
- NCT01957228
- Testing
- bone biopsies
- Where
- France
- Volunteers
- 980 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Transhumeral Amputation
Quantifying Prosthetic Socket Interface Movement
This study will quantify motion occurring at the socket interface of transhumeral prosthesis users during common tasks. Participants in the study will use a body powered prosthesis with a hosmer hook terminal device.
- Trial name
- NCT01932892
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of South Florida
Dental Implants
Digital Assessment of a Full Digital Implant-Prosthetic Workflow for a Prefabricated Single Implant-Supported Restoration
The aim of the present study was to evaluate the accuracy of a prefabricated digitally planned provisional restoration on a single- implant placed with a fully guided surgical protocol.
- Trial name
- NCT04329169
- Testing
- Virtual Implant Planning
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Nourhan M.Aly
Prosthetic Valve Thrombosis
Assessment of TRanscathetEr and Surgical Aortic BiOprosthetic Valve Thrombosis and Its TrEatment With Anticoagulation
This is a prospective study designed to evaluate the structural and functional integrity of transcatheter or surgical bioprosthetic valves with multimodality imaging.
- Trial name
- RESOLVE (NCT02318342)
- Testing
- Warfarin
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Cedars-Sinai Medical Center
Arthroplasty, Replacement, Knee
MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence
Following a prosthetic knee joint infection, two types of operative approach can be undertaken to treat the infection: a one-stage or two-stage revision operation.
- Trial name
- MIKROBE (NCT04458961)
- Testing
- One-stage, Two-stage
- Where
- 2 sites in United Kingdom
- Volunteers
- 3 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Amputation, Lower Limb
Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray
Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning.
- Trial name
- NCT05287646
- Testing
- Suction Suspension First, Elevated Vacuum Suspension First
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Vascular Prosthetic Graft Infection
Prevention of Vascular Graft Infection With Hypochlorous Acid
This is a study of the use of an antibacterial solution, Hypochlorous acid, to prevent infection in vascular surgery bypass grafts.
- Trial name
- NCT07678632
- Testing
- Hypochlorous acid
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Hamilton Health Sciences Corporation
Hip Prosthetic Joint Infection
Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection
The purpose of this study is to evaluate the efficacy of oral linezolid-rifampin combination therapy (over 4 or 6 weeks) versus the standard of care in the treatment of Gram-positive prosthetic hip joint infection with a…
- Trial name
- LIZ-BONE (NCT01757236)
- Testing
- VANCOMYCIN, CEFTRIAXONE, CLINDAMYCIN
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Bone and Joint Infection, Antibiotic Resistant Staphylococcus Aureus Infection
Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin
S. aureus and coagulase-negative staphylococci are the most frequent bacteria responsible for PJI (prosthetic joint infection). The aim of this study is to describe the use of rifampicin.
- Trial name
- IPASTAPH (NCT03750721)
- Testing
- Role of rifampin in staphylococcal PJI
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Hospices Civils de Lyon
Amputation
Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users
The goal of this research is to analyze data from smartphone-based and wearable sensors, using advanced machine-learning and data-mining techniques, and to combine this information with performance-based measures…
- Trial name
- NCT03930199
- Testing
- Needs-based intervention (physical, psychological, or both)
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation
Dynamic Management of Excess Residual Limb Pressure With New Smart Socket Technology/Intelligent Prosthetic Socket With Variable Volume and Elevated Vacuum Systems
This study centers around the imaging of internal structures of residual limb by means of modern radiographic imaging techniques (Dynamic Radiography-DRSA).
- Trial name
- SMARTsocket- (NCT01108536)
- Testing
- adaptive prosthetic socket
- Where
- 3 sites in United States, Cyprus
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Milwaukee
Infections Joint Prosthetic
Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head…
- Trial name
- NCT06451224
- Testing
- Questionnaire
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- South Valley University
Amputation
A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations
Objective/Hypotheses and Specific Aims: The first aim of this proposal is to determine the effects of commercial prosthetic feet of varying stiffness on stability and falls-related outcomes in Veterans with TTA.
- Trial name
- NCT05473065
- Testing
- Multiaxial Prosthetic Foot Emulator, Commercially available prosthetic feet
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Obstructive Thrombus
Thrombolytic Therapy Versus Surgery for Obstructive Prosthetic Valve Thrombosis
Prosthetic heart valve thrombosis is a serious complication with high mortality and morbidity The best treatment of PVT is controversial, although surgery and thrombolysis options have been available.
- Trial name
- NCT02243839
- Testing
- Thrombolytic Therapy, Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Mitral Prosthetic Valve Stenosis and Regurgitation
Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV)
Transcatheter valve-in-valve implantation has emerged as a valid alternative to redo surgery for patients with surgical bioprosthetic dysfunction.
- Trial name
- SURVIV (NCT04402931)
- Testing
- Transcatheter Valve-in-Valve Intervention, Redo Mitral valve surgery
- Where
- 7 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Surgical Site Infection
Detection of Staph Colonization in Pre-op Arthroplasty Patients
This study will evaluate which body site(s) provide the best source of possible staph presence in participants undergoing total joint arthroplasty.
- Trial name
- Staph (NCT01648088)
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Defect; Internal Prosthetic Device, Implants and Grafts, Orthopedic, Bone Graft
Clinical Application of Personal Designed 3D Printing Implants in Bone Defect Restoration
Objective: Clinical application of 3D printing implant in bone defect treatment. Study design: multicenter randomized controlled study .
- Trial name
- NCT03166917
- Testing
- 3D printing implant, autogenous bone grafting
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- fang guofang