Clinical trials: Prosthetic Infection
Endocarditis
Suppressive Antibiotic Therapy for Endocarditis
Endocarditis are deadly infections, which nowadays occurs mainly among older patients with multiple comorbidities. The incidence is notably high among patients with valvular prosthetic or implantable devices.
- Trial name
- SATIE (NCT06107309)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Prosthetic Joint Infection
Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection
The PROOF Study is an open prospective interventional non-randomized study which aim is to determine the outcome / effect and safety of fosfomycin in patients with hip, knee or shoulder PJI.
- Trial name
- PROOF (NCT03260010)
- Testing
- Fosfomycin
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Pro-Implant Foundation
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection
To determine if oral antibiotic treatment with CEM-102 and Rifampin is as effective and safe as the standard of care antibiotic therapy for the treatment of hip and knee prosthetic joint or spacer infections
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Infected Spacers
- Trial name
- NCT01756924
- Testing
- CEM-102, IV or Oral standard of care antibiotics, Rifampin
- Where
- 13 sites in United States
- Volunteers
- 14 people
- Sponsor
- Arrevus Inc.
Chronic PJIs
Heraeus MicroDTTect Lyon Pilot Studyprosthetic Joint Infections (PJIs)
Prosthetic joint infections (PJIs) are one of the main causes of implant failure after joint arthroplasty. Identification of the causal organism is crucial for successful treatment.
- Trial name
- NCT04371068
- Testing
- Culture of removed prosthesis using DTT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Total Knee Arthroplasty, Prosthetic-joint Infection
Methylene Blue in Total Knee Arthroplasty (TKA)
The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint…
- Conditions
- Total Knee Arthroplasty, Prosthetic-joint Infection, Irrigation
- Trial name
- NCT07324954
- Testing
- Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- NCT04618276
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Osteoarticular Infections, Intensive Care Patients
Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.
This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated…
- Conditions
- Osteoarticular Infections, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS² (NCT07107685)
- Testing
- Global cohort
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Quality of Life, Prosthetic Joint Infection
Quality of Life in Patients Having a Prosthetic Joint Infection
Bone and joint infections (BJI) are rare serious pathology which can lead to a very heavy handicap and sometimes to the life threatening. These are devastating diseases whose diagnosis is difficult.
- Trial name
- QuaVIPA (NCT03307109)
- Testing
- Quality of life
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Hospices Civils de Lyon
Prosthetic Joint Infection (PJI)
Detection of Biomarkers for Prosthetic Infection Type - (DEBIT)
Prosthetic joint infection (PJI) is a significant cause of failure in hip and knee arthroplasty and is often difficult to diagnose using current methods.
- Trial name
- DEBIT (NCT07838064)
- Testing
- Prosthetic joint replacement
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Prosthetic Joint Infection, Antibiotic Resistant Infection
Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in At-risk Patients
One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.
- Trial name
- NCT03848091
- Testing
- Antibiotic pretreatment
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hospices Civils de Lyon
Prosthesis-Related Infections
PRO-DIAG: Improved Diagnosis of Prosthetic Joint Infections
Implantation of joint prostheses is currently the second largest diagnosis-related group in the Danish health service, and in view of the demographic development and spread of lifestyle diseases, this type of intervention is…
- Trial name
- PRO-DIAG (NCT03444571)
- Testing
- revision surgery
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aalborg University
Bone Tumours, Bone Infection
Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection
Translational research aimed at improving diagnostic accuracy of musculoskeletal infection and musculoskeletal tumours using machine learning applied to clinical data, histopathological sections and genomic sequencing.
- Conditions
- Bone Tumours, Bone Infection, Prosthetic Joint Infection, Prosthetic Infection
- Trial name
- AIortho (NCT04746001)
- Testing
- Genomic sequencing, Histological examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
Joint Infection
Bacterial Epidemiology and Empirical Antibiotherapy in Patients With Prosthetic Joint Infection
The purpose of this study is to establish a bacterial epidemiology in patients who present a prosthetic joint infection and for which a surgery is necessary.
- Trial name
- NCT03191292
- Where
- France
- Volunteers
- 567 people
- Sponsor
- Hospices Civils de Lyon
Prostheses Infection
Efficacy and Tolerance of 4 Weeks of Tedizolid in Prosthetic Joint Infections Treated With Implant Removal
To evaluate the efficacy of 4 weeks of 200 mg/24h of tedizolid for prosthetic join infections caused by tedizolid susceptible microorganisms treated with implant removal in one or two stages at 6 months of followup after stopping…
- Trial name
- PROTEDI (NCT03746327)
- Testing
- Sivextro 200 milligrams Oral Tablet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Prosthetic Joint Infection
68Ga-citrate PET/CT for the Diagnosis of Chronic Prosthetic Hip or Knee Infection
Diagnosis of chronic prosthetic joint infection (PJI) can be difficult. 68Ga-citrate Positron Emission Tomography/Computed Tomography (PET/CT) has been recently developed and has many advantages such as high resolution and low…
- Trial name
- Gal-I-TEP (NCT04938193)
- Testing
- 68Ga-citrate PET/CT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Bordeaux
Surgical Site Infection
Antibiotic Prophylaxis in Clean Surgery. Impact on Surgical Site Infection
This is a randomized control study of antibiotic uses in clean non prosthetic surgeries. One group will be given antibiotic prophylaxis, other will receive a placebo.
- Trial name
- NCT03595852
- Testing
- Cefazolin
- Where
- Rwanda
- Volunteers
- 138 people
- Sponsor
- University of Rwanda
Prosthetic Joint Infection
Study of the Lived Experience of Patients With Prosthetic Joint Infection, Their Families, and Healthcare Professionals. Development of a Therapeutic Education Program for Patient Care (TEP).
The PROTHEE-QUALI study (Qualitative study of the lived experience of patients with prosthetic joint infection, their accompanying persons and health professionals and construction of a therapeutic education program for…
- Trial name
- PROTHEE-QUALI (NCT07409402)
- Testing
- Exploration of the lived experience of patients with prosthetic joint infection (PJI), their families, and healthcare professionals
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lower Limb Megaprosthetis Infection
Epidemiology, Risk Factors, and Outcomes of Infections of Lower Limb MEGAprostheses
Retrospective, multicenter, non-profit observational study. The study will include consecutive patients who underwent lower-limb megaprosthesis implantation at the participating Centers between January 1, 2020, and June 30, 2023.
- Trial name
- EROMEGA (NCT07544212)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Infection
LEVOS - Levofloxacin and Rifampicin Therapy in the Treatment of OsteoArticular Prothethic Infection
The primary objective is: to assess the microbiological success of the combination of levofloxacin and rifampicin, administered for 32 to 37 days, as oral replacement therapy of an empirical antibiotic therapy of a maximum of 5…
- Trial name
- NCT00906048
- Testing
- Levofloxacin (HR355) and Rifampicin Therapy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Sanofi