Clinical trials: Prosthetic-joint Infection
Prosthetic Joint Infection
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections
The objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score..
- Trial name
- METAGENOS (NCT06062251)
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Brest
Osteoarticular Infection, Intensive Care Patients
OsteoArticular Sepsis in Intensive Care unitS
This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses).
- Conditions
- Osteoarticular Infection, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS (NCT06627842)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarticular Infections, Intensive Care Patients
Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.
This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated…
- Conditions
- Osteoarticular Infections, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS² (NCT07107685)
- Testing
- Global cohort
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection
TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making pathogens substantially more susceptible to established antibiotic treatment regimens.
- Trial name
- NCT06621251
- Testing
- TRL1068 (calpurbatug), a human monoclonal antibody, DAIR
- Where
- 11 sites in United States
- Volunteers
- 60 people
- Sponsor
- Trellis Bioscience LLC
Total Knee Arthroplasty, Prosthetic-joint Infection
Methylene Blue in Total Knee Arthroplasty (TKA)
The purpose of this pilot study is to determine the volume of irrigation required to achieve macroscopic clearance of contaminants during a debridement, antibiotics, and implant retention (DAIR) procedure for periprosthetic joint…
- Conditions
- Total Knee Arthroplasty, Prosthetic-joint Infection, Irrigation
- Trial name
- NCT07324954
- Testing
- Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection
Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI).
- Conditions
- Chronic Periprosthetic Joint Infection, Suspected Periprosthetic Joint Infection, Prosthetic Joint Failure of Unclear Etiology
- Trial name
- PJI MAP/DEF (NCT07494630)
- Testing
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- University Hospital, Ghent
Prosthetic Joint Infection, Hip Prosthesis Infection
Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leuven
Prosthetic Joint Infection (PJI) of a Total Hip Replacement (THR) is a disastrous complication of an otherwise extremely successful surgical procedure.
- Trial name
- PROFITH (NCT05000723)
- Testing
- Standard of care
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Joint Arthroplasty, Shoulder
Reduction of Bacterial Seeding in Total Shoulder Arthroplasty
The purpose of this study is to compare the growth of intra-operative tissue cultures of Cutibacterium Acnes after primary shoulder replacement when using a no-prep control group versus Prontosan wound gel applied to the skin…
- Conditions
- Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
- Trial name
- NCT07406893
- Testing
- Prontosan Wound Gel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Louis University
Prosthetic Joint Infections of Hip, Bacteriophage Therapy
Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip.
- Trial name
- NCT07461337
- Testing
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Prosthetic-joint Infection
The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee
The purpose of this study is to determine whether probiotics in addition to standard of care (SOC) can improve immunological markers following treatment for prosthetic joint infection (PJI).
- Trial name
- NCT06919913
- Testing
- Culturelle Digestive Daily Probiotic Capsule
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- NYU Langone Health
Soft Tissue Infections, Mediastinitis
Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
The goal of this observational study is to measure how well the antibiotic delafloxacin penetrates into the blood and various body tissues in adult patients over 18 years old.
- Conditions
- Soft Tissue Infections, Mediastinitis, Osteomyelitis/Septic Arthritis, Prosthetic Joint Infection
- Trial name
- DELA-PLAT (NCT07426471)
- Testing
- delafloxacin
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Prosthetic Joint Infection
Study of the Lived Experience of Patients With Prosthetic Joint Infection, Their Families, and Healthcare Professionals. Development of a Therapeutic Education Program for Patient Care (TEP).
The PROTHEE-QUALI study (Qualitative study of the lived experience of patients with prosthetic joint infection, their accompanying persons and health professionals and construction of a therapeutic education program for…
- Trial name
- PROTHEE-QUALI (NCT07409402)
- Testing
- Exploration of the lived experience of patients with prosthetic joint infection (PJI), their families, and healthcare professionals
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prosthetic-joint Infection, Arthroplasty Complications
Knee Prosthetic Joint Infection Antibiotic Elution
Patients presenting with prosthetic joint infections of a total knee replacement who are treated with an antibiotic spacer will be observed prospectively for their response to treatment and antibiotic elution profiles will be…
- Trial name
- NCT06023238
- Testing
- Treatment of Chronic TKA PJI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Prosthetic Joint Infection, Unicompartmental Knee Arthroplasty
Metal Artifact Reduction Sequence MRI for Surgical Decision-Making in Infected Unicompartmental Knee Arthroplasty
A single-center retrospective cohort study was conducted in the Department of Orthopedics of Fujian Medical University Affiliated First Hospital.
- Trial name
- NCT07208968
- Where
- China
- Volunteers
- 28 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prosthetic Joint Infection
Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers
Total joint replacement (TJR) is an increasing effective procedure in orthopedics. However, TJR failure due to aseptic or septic loosening remains an important problem, often due to predisposing factors of the patient, which…
- Trial name
- DECISION (NCT04858217)
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prosthetic Joint Infections of Hip
Bacteriophage Therapy for Morganella Morganii Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Morganella morganii prosthetic joint infection of the hip.
- Trial name
- PHAGE-MOM-001 (NCT06814756)
- Testing
- phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Prosthetic Joint Infections of Hip, Staphylococcus Aureus Infection
Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage cocktail to treat and prevent the recurrence of a methicillin-susceptible Staphylococcus aureus prosthetic joint infection…
- Trial name
- PHAGE-2024-01 (NCT06456424)
- Testing
- Phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Osteomyelitis, Prosthetic Joint Infection
Short or Long Antibiotic Regimes in Orthopaedics
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with bone or joint infections are usually…
- Conditions
- Osteomyelitis, Prosthetic Joint Infection, Diabetic Foot
- Trial name
- SOLARIO (NCT03806166)
- Testing
- Shorter Systemic Antibiotics, Standard treatment
- Where
- 23 sites in Germany, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Oxford University Hospitals NHS Trust