Clinical trials: Prosthetic-joint Infection
Prosthetic Joint Infection
Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections
TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making these pathogens substantially more susceptible to established antibiotic treatment regimens.
- Trial name
- NCT04763759
- Testing
- TRL1068, a human monoclonal antibody
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- Trellis Bioscience LLC
Prosthetic Joint Infection, Staphylococcus Aureus
Evaluation of the Antibiofilmogramme Test During Orthopaedic Device-Related Infection
This is an observational study that does not change routine care. The primary objective of this study is to investigate the correlation between the administration of an antibiotherapy able to prevent biofilm formation according…
- Conditions
- Prosthetic Joint Infection, Staphylococcus Aureus, Biofilm
- Trial name
- BJIBiofilm (NCT03263832)
- Testing
- Antibiofilmogramme
- Where
- France
- Volunteers
- 45 people
- Sponsor
- BioFilm Control
Revision Total Hip Arthroplasty, Revision Total Knee Arthroplasty
Tissue Culture Versus Swab Culture in Prosthetic Joint Infections
The main purpose of this study is to compare the effectiveness and accuracy of tissue cultures and swab cultures to diagnose prosthetic joint infection.
- Trial name
- NCT01482533
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Prosthetic Joint Infection, Severe Infection
Phage Safety Cohort Study
This cohort study aims to describe the adverse events related to the use of bacteriophages to treat serious infections, data from the literature being almost non-existent on this subject.
- Trial name
- PHA-SA-CO (NCT04650607)
- Testing
- Adverse event after injection of phages
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Prosthetic Joint Infection
The Influence of Antibiotic Prophylaxis on Intraoperative Prosthetic Joint Infection Cultures
Total joint replacement is a common clinical practice for patients suffering from disabling arthritis, since it provides significant pain relief and functional recovering.
- Trial name
- NCT02413034
- Testing
- Cefazolin, Control group
- Volunteers
- 28 people
- Sponsor
- Parc de Salut Mar
Prosthetic Joint Infection
NGS vs Culture Outcomes for Treatment of PJI
This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.
- Trial name
- NCT05247281
- Testing
- Culture-based treatment, Next Generation Sequencing (NGS) with Culture
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- Center for Innovation and Research Organization
Osteoarthritis, Hip, Total Hip Arthroplasty
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA
Aim: To compare the effect of one single dose versus multiple doses of prophylactic antibiotics administered within 24 hours, on the development of PJI in patients with osteoarthritis undergoing primary THA.
- Conditions
- Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection
- Trial name
- ProHipQ-OA (NCT05530551)
- Testing
- Antibiotic dosage practice
- Where
- 36 sites in Denmark
- Volunteers
- 20,000 people
- Sponsor
- Soren Overgaard
Osteolysis, Arthroplasty Complications
Plasmafit® Revision Structan® Hip Endoprosthesis Cup
The aim of this observational study is to collect clinical and radiological results of the new Plasmafit® Revision Structan® Hip Endoprosthesis Cup in a standard patient population and when used in routine clinical practice.
- Conditions
- Osteolysis, Arthroplasty Complications, Instability of Prosthetic Joint, Degenerative Osteoarthritis
- Trial name
- NCT04255966
- Testing
- Plasmafit® Revision Structan®
- Where
- 4 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Refractory Bone or Joint Infections
Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections
To evaluate the safety and effectiveness of oral sodium fusidate (CEM-102) as chronic antibiotic for the treatment of bone or joint infections.
- Trial name
- NCT02569541
- Testing
- sodium fusidate
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Arrevus Inc.
Prosthetic Joint Infections
[124I]FIAU PET-CT Scanning in Patients With Pain in a Prosthetic Knee or Hip Joint
This protocol will evaluate the sensitivity and specificity of [124I]FIAU as a diagnostic imaging agent for the detection of prosthetic joint infections in patients.
- Trial name
- PJI (NCT01705496)
- Testing
- [124I]FIAU
- Where
- 10 sites in United States
- Volunteers
- 23 people
- Sponsor
- BioMed Valley Discoveries, Inc
Prosthetic Joint Infection
Tedizolid Prolonged Treatment for Prosthetic Joint Infections
Pilot study the aim of which is to obtain reliable data on the tolerance, compliance and efficacy of Tedizolid used as prolonged (≥ 6 weeks) monotherapy or in combination therapy for the treatment of patients with orthopedic…
- Trial name
- TEDIZOAM (NCT03378427)
- Testing
- Tedizolid Phosphate 200 MG [Sivextro]
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- Tourcoing Hospital
Periprosthetic Joint Infection, Anti-Bacterial Agents
Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery.
- Trial name
- PACER-PJI (NCT05284318)
- Testing
- Antibiotics treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prosthetic-joint Infection
Surgiphor vs Saline Joints
This study will be an open-label superiority, multicenter, single-blind, controlled randomized clinical trial investing the role of a PVP-I irrigation solution (Surgiphor) in reducing the risk of acute PJI in the 90 days…
- Trial name
- NCT05434260
- Testing
- Surgiphor Irrigation Solution, Sterile saline
- Where
- 4 sites in United States
- Volunteers
- 868 people
- Sponsor
- Center for Innovation and Research Organization
Prosthetic Joint Infection
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections
The objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score..
- Trial name
- METAGENOS (NCT06062251)
- Where
- 6 sites in France
- Volunteers
- 144 people
- Sponsor
- University Hospital, Brest
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
Study to Evaluate the Efficacy and Safety of TRL1068 for the Treatment of Prosthetic Joint Infection
TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making pathogens substantially more susceptible to established antibiotic treatment regimens.
- Trial name
- NCT06621251
- Testing
- TRL1068 (calpurbatug), a human monoclonal antibody, DAIR
- Where
- 11 sites in United States
- Volunteers
- 60 people
- Sponsor
- Trellis Bioscience LLC
Prosthetic Joint Infection, Osteomyelitis
Population Pharmacokinetic Model of Rifampicin in Staphylococcal Osteoarticular Infections
Staphylococcal osteoarticular infections (OAIs), including prosthetic joint infections and chronic osteomyelitis, represent a major cause of morbidity.
- Conditions
- Prosthetic Joint Infection, Osteomyelitis, Staphylococcal Infections
- Trial name
- Ciné-RIF (NCT07788404)
- Testing
- This study focuses on the pharmacokinetics of rifampicin and levofloxacin or ciprofloxacin, which are used in the treatment of osteoarticular infections caused by susceptible staphylococci as part of
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Bone and Joint Infection
Lyon PJI Retrospective Cohort Study
Bone and joint infections (BJI), although infrequent (prevalence of 70 per 100,000 in France), have a significant economic and clinical impact.
- Trial name
- NCT04722926
- Testing
- PJI
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Prosthetic Joint Infection
The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection
This is a prospective multicenter study. All patients presenting for revision hip or knee arthroplasty for all indications under the respective surgeon's care may be eligible.
- Trial name
- NCT03200470
- Testing
- No intervention: sample collection study
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics