Clinical trials: Protein Digestion
Primary Liver Cancer, SCLC
A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection
This is a study to evaluate the safety of MRX34 in patients with primary liver cancer or other selected solid tumors or hematologic malignancies. The drug is given intravenously, for 5 days in a row and then two weeks off.
- Conditions
- Primary Liver Cancer, SCLC, Lymphoma, Melanoma
- Trial name
- NCT01829971
- Testing
- MRX34
- Where
- 10 sites in United States, South Korea
- Volunteers
- 155 people
- Sponsor
- Mirna Therapeutics, Inc.
Lung Cancers, Pancreatic Cancer
18F Labeled FAP Targeted Molecular Probe in Early Tumor Diagnosis
Evaluate the safety of the novel FAP targeted molecular probe 18F-FAPI-YQ104 labeled with radioactive isotopes in clinical applications and verify its effectiveness in tumor diagnosis.
- Conditions
- Lung Cancers, Pancreatic Cancer, Neuroendocrine Tumors, Thyroid Cancer
- Trial name
- NCT06937112
- Testing
- PET-CT examination
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gluten Digestion
Effect of AN-PEP Enzyme on Gluten Digestion
The aim is to demonstrate how fast and to what extent AN-PEP can degrade gluten in vivo in the stomach and how much gluten enters the small intestine.
- Trial name
- NCT01335503
- Testing
- AN-PEP
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- DSM Food Specialties
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Multiple Myeloma
Standard Care Alone or With Acupuncture for CIPN in Breast Cancer and Multiple Myeloma
The purpose of this study is to determine whether the addition of acupuncture to standard treatment reduces the level of chemotherapy induced peripheral neuropathy experienced by patients with breast cancer, multiple myeloma…
- Conditions
- Breast Cancer, Multiple Myeloma, Gastrointestinal Cancer, Gynaecological Cancer
- Trial name
- ACUFOCIN (NCT02275403)
- Testing
- Acupuncture, Medication taken to manage the symptom burden of CIPN
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- The Christie NHS Foundation Trust
Liver Fibrosis, Positron Emission Tomography
Clinical Application of Fibroblast Activation Protein PET/MRI in Liver Fibrosis
Positron Emission Tomography (PET) provides a valuable tool for the diagnosis and staging of liver fibrosis. Activation of hepatic stellate cell (HSC) is a key link in the pathophysiological development of liver fibrosis.
- Conditions
- Liver Fibrosis, Positron Emission Tomography, Magnetic Resonance Imaging
- Trial name
- NCT04605939
- Testing
- PET/MR, PET/CT
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
This phase Ib trial determines if samples from a patient's cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8, Anemia, Ann Arbor Stage III Hodgkin Lymphoma
- Trial name
- NCT03878524
- Testing
- Abemaciclib, Abiraterone, Afatinib
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Pancreatic Ductal Adenocarcinoma, Gastric Cancer
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Phase I/IIa image-guided, alpha-particle therapy study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in patients with solid tumors that are known to be Fibroblast Activation Protein (FAP)-positive.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Gastric Cancer, Esophageal Cancer, Colorectal Cancer
- Trial name
- NCT06710756
- Testing
- [203Pb]Pb-PSV359, [212Pb]Pb-PSV359
- Where
- 16 sites in United States
- Volunteers
- 112 people
- Sponsor
- Perspective Therapeutics
Peptic Ulcer, Gastritis
Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein
Carbohydrate enriched-drinks has been used as preoperative treatment up to two hours before anesthesia. These drinks are safe and are not associated to bronchial aspiration during anesthesia.
- Trial name
- NCT01828645
- Testing
- Carbohydrate plus whey protein enriched drink
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Mato Grosso
Cystic Fibrosis, Hemophilia A
Medication Adherence and Non-adherence in Adults With Rare Disease
The purpose of this study is to use the Medication Adherence Reasons Scale (MAR-Scale) to determine the extent of non-adherence to specific medications indicated to treat cystic fibrosis, hemophilia (A or B), idiopathic pulmonary…
- Conditions
- Cystic Fibrosis, Hemophilia A, Hemophilia B, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT04541875
- Testing
- MAR-Scale
- Volunteers
- healthy volunteers welcome
- Sponsor
- Xperiome
Advanced Malignant Solid Neoplasm, C-KIT Tyrosine Kinase Protein Overexpression
Ipilimumab and Imatinib Mesylate in Advanced Cancer
This phase I trial studies the side effects and best dose of ipilimumab and imatinib mesylate in treating patients with solid tumors that have spread to other places in the body or cannot be removed by surgery.
- Conditions
- Advanced Malignant Solid Neoplasm, C-KIT Tyrosine Kinase Protein Overexpression, Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Gastrointestinal Stromal Tumor
- Trial name
- NCT01738139
- Testing
- Imatinib Mesylate, Ipilimumab
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Colorectal Cancer
Study of Glutamine as Prophylaxis for Irinotecan Induced Diarrhea
Irinotecan (7-ethyl-10- {4(-1-piperidino)-1-piperidino} carbonyloxy camptothecin) is a semisynthetic camptothecin derivative introduced in the 1980's.
- Trial name
- NCT00255229
- Testing
- Glutamine
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- AHS Cancer Control Alberta
Healthy Volunteers
Determination of the Glycemic Index and the Insulinemic Index of a Sweetener Syrup
The purpose of the study is to determine the glycemic index and the insulinemic index of a sweetener syrup
- Trial name
- NCT00717912
- Testing
- Experimental sweetener syrup, Classical sweetener syrup, Classical sugar syrup
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Routin SA
Tube Feeding
Effect of Methylnaltrexone (Relistor) on Digestion and Tolerance to Tube Feeding in Patients Treated With Opiates
It is hypothesized that using methylnaltrexone in addition to pain killer narcotics (opiates) in patients will result in increased tube feeding rates with more frequent nutrition at goal calorie rate.
- Trial name
- NCT01360372
- Testing
- Methylnaltrexone, Saline injection
- Where
- 2 sites in United States
- Sponsor
- Drexel University
Inflammatory Bowel Diseases, Ulcerative Colitis
The Nordic IBD Treatment Strategy Trial
Purpose: To demonstrate that personalised therapy can be delivered to patients with IBD, by treating patients with an increased risk of poor disease course, defined by a serum protein signature at diagnosis, with a top-down…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NORDTREAT (NCT05180175)
- Testing
- Top down treatment if patient at high risk
- Where
- 15 sites in Denmark, Iceland and 2 more
- Volunteers
- 300 people
- Sponsor
- Region Örebro County
Irritable Bowel Syndrome
SBI in Children With d-IBS
IBS is the most common diagnosis in new patients in our pediatric gastroenterology clinic, accounting for 36 % of all new patients.
- Trial name
- NCT02609529
- Testing
- Medical Food
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Non-small Cell Lung Cancer, Histiocytic Neoplasm
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
BDTX-4933-101 is a first-in-human, open-label, Phase 1/2 dose escalation, dose optimization and expansion study designed to evaluate the safety and tolerability of S241656 as monotherapy and in combination with other anti-cancer…
- Conditions
- Non-small Cell Lung Cancer, Histiocytic Neoplasm, Histiocytosis, BRAF Gene Mutation
- Trial name
- NCT05786924
- Testing
- S241656, FOLFOX6/FOLFOX7, FOLFIRI
- Where
- 49 sites in United States, Australia and 8 more
- Volunteers
- 554 people
- Sponsor
- Institut de Recherches Internationales Servier
Microbial Colonization, Metabolic Disease
Pilot Haskap Metabolite Timing Project
Diet is a key factor in managing health and individuals at risk of developing metabolic syndrome or other chronic diseases have the opportunity to use diet as a tool to improve their health.
- Conditions
- Microbial Colonization, Metabolic Disease, Digestion
- Trial name
- PHMTiming (NCT06938386)
- Testing
- Haskap
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Montana State University
Ulcerative Colitis, Protein Metabolism
Metabolic Response to Infliximab in Pediatric Ulcerative Colitis
The metabolic response to ulcerative colitis, including increased proteolysis and lipolysis and changes in energy expenditure, plays a significant role in the resulting malnutrition from which these patients suffer.
- Conditions
- Ulcerative Colitis, Protein Metabolism, Energy Expenditure
- Trial name
- NCT00586807
- Testing
- Stable amino acid isotopes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Protein-Energy Malnutrition, Hemodialysis
Impact of Cannabis Oil on Nutrition in Hemodialysis Patients Study (ICON-HP Study)
The study will be performed in two parts: 1) The pharmacokinetic (PK) part and 2) The appetite and nutritional evaluation part. The PK part of study will be conducted in open label manner on 10 end stage kidney disease (ESKD)…
- Conditions
- Protein-Energy Malnutrition, Hemodialysis, Appetite Disorders
- Trial name
- ICON-HP (NCT03664141)
- Testing
- Cannabis oil
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center