Clinical trials: Protein Digestion
Acute Appendicitis
Acute Appendicitis: The Influence of C-reactive Protein and Leucocytes on Clinical Decision-making
Aim: To investigate if the results of CRP and leucocytes had any positive or negative influence on the surgeon's decision-making when handling patients with suspected AA.
- Trial name
- NCT02304653
- Testing
- Clinical descision making
- Where
- Denmark
- Volunteers
- 226 people
- Sponsor
- Odense University Hospital
Colorectal Cancer, Pancreatic Cancer
Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic Cancer
Phase 1 study for patients with resected PDAC after neoadjuvant and/ or adjuvant chemotherapy and/or radiation, as well as patients with metastatic colorectal cancer who have exposure to 2 or more lines of chemotherapy, to…
- Trial name
- NCT04117087
- Testing
- KRAS peptide vaccine, Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Inflammatory Bowel Diseases, Mucosal Inflammation
Phase Angle and Chronic Intestinal Inflammatory Diseases
Phase angle (PhA) is a biometric parameter measured by bioimpedance analysis (BIA), which reflects organism cellularity and tissues hydration.
- Conditions
- Inflammatory Bowel Diseases, Mucosal Inflammation, Leukocyte L1 Antigen Complex, C-Reactive Protein
- Trial name
- PHIBO (NCT05106738)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bari
Hemophilia, AIDS
Host Genetic Factors Influencing HIV1 and HCV Viral Loads and AIDS Clinical Progression in a Hemophilia Cohort (HGDS-3)
Background: Over 80% of the hemophiliac population who became infected with HIV prior to 1985 are also co-infected with HCV. Thus, hemophiliacs represent an important population for studies of the natural history of these chronic…
- Trial name
- NCT00340548
- Where
- 15 sites in United States
- Volunteers
- 333 people
- Sponsor
- National Cancer Institute (NCI)
Respiratory Infections, Diarrhea
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM
Vitamin A deficiency is an important health problem globally including Bangladesh. The problem is greater among under-five children, particularly in malnourished.
- Conditions
- Respiratory Infections, Diarrhea, Malnutrition
- Trial name
- NCT00388921
- Testing
- Vitamin A
- Where
- Bangladesh
- Volunteers
- 260 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pancreatitis
Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis
Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption.
- Trial name
- NCT01154608
- Testing
- Creon, No enzyme therapy
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Protein Utilization
Digestion and Absorption of Postbiotic Regulatory Proteins
The goal of this clinical trial is to find out whether a daily postbiotic supplement can help healthy, physically active adults digest and absorb dietary protein better.
- Trial name
- NCT07900204
- Testing
- Inactivated Probiotics
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Metastatic Colorectal Cancer
A Study Assessing Adverse Events and Disease Activity of Intravenously (IV) Infused Telisotuzumab Adizutecan in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide and in China. The purpose of this study is to assess adverse events and change in disease activity of intravenously (IV) infused telisotuzumab…
- Trial name
- NCT06614192
- Testing
- Telisotuzumab Adizutecan
- Where
- 51 sites in United States, Australia and 5 more
- Volunteers
- 74 people
- Sponsor
- AbbVie
Protein Digestion Kinetics
Real-time Amino Acid Profiling
This study was designed to obtain information about the effect of new combinations of dairy proteins, in small servings with high protein concentrations, on postprandial amino acid kinetics in blood in an older population.
- Trial name
- RAP (NCT03547362)
- Testing
- Casein, Dairy protein blend 1, Whey protein
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Hepatobiliary Diseases
The Function of PET Molecular Imaging Targeting Fibroblast Activation Protein in the Hepatobiliary Malignancies
Patients with high clinical suspicion of hepatobiliary malignancies should undergo PET/CT examination with two imaging agents, 68Ga-FAPI (fibroblast activation protein inhibitor) and 18F-FDG within one week, and collect tumor…
- Trial name
- NCT05264688
- Testing
- 68Ga-FAPI-04 imaging agent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhongnan Hospital
Colorectal Cancer, Colorectal Neoplasms
AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer
Background: T-cells are white blood cells that can find and kill germs and tumors. Cancer can keep T-cells from working. Researchers think a new drug called AMP-224 might help the T-cells in people with cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma
- Trial name
- NCT02298946
- Testing
- AMP-224, Stereotactic Body Radiation Therapy(SBRT), Cyclophosphamide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Patients on Long-term Proton Pump Inhibitor Therapy
Probiotic Modulation of Intestinal Microbiota in Long-term Intake of Proton Pump Inhibitors
Long-term proton pump inhibitor use has been linked to intestinal dysbiosis, inflammation and gastrointestinal symptoms. Probiotics has been shown to correct dysbiosis, reduce inflammation and strengthen the gut barrier.
- Trial name
- NCT03220802
- Testing
- OMNI-BiOTiC PPI
- Where
- Austria
- Volunteers
- 57 people
- Sponsor
- Medical University of Graz
Cholangiocarcinoma, Multiple Myeloma
Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)
The overall goal of the WU-PE-CGS is to build a rigorous, scientific evidence base for approaches that direct engagement of cancer patients and post-treatment cancer survivors as participants in cancer research, and to…
- Conditions
- Cholangiocarcinoma, Multiple Myeloma, Colon Cancer, Rectal Cancer
- Trial name
- NCT06340646
- Testing
- Return of Genetic Results: Biomarker information from cancer cells, Return of Genetic Results: Inherited mutations related to cancer, Return of Genetic Results: Inherited mutations related to other medical issues
- Where
- United States
- Volunteers
- 990 people
- Sponsor
- Washington University School of Medicine
Colitis, Ulcerative, Inflammatory Bowel Diseases
Casein Glycomacropeptide in Active Distal Ulcerative Colitis (Pilot Study)
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- NCT01534312
- Testing
- CGMP protein, Maximal oral 5ASA
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
Overweight, Obese
The Effect of Protein-enriched Diet on Body Composition and Appetite
Obesity is a major problem worldwide and current dietary interventions are not proving to be enough to cease the increase in levels of obesity and its detrimental side effects, such as nonalcoholic fatty liver disease (NAFLD).
- Conditions
- Overweight, Obese, Metabolic Syndrome, Non Alcoholic Fatty Liver Disease
- Trial name
- ProteinRich (NCT01634048)
- Testing
- High Protein, low calorie meal replacement
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Inflammatory Bowel Disease, Ulcerative Colitis
Early Changes in Inflammatory Indices and Healing in IBD
This prospective observational study aims to evaluate early changes in blood-based inflammatory indices during the first 4 weeks after treatment initiation or escalation and their relation to endoscopic and histological healing…
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT07855055
- Volunteers
- 138 people
- Sponsor
- Assiut University
Intestinal Malabsorption, Critical Illness
Protein-bound Versus Free Amino Acid Nutrition During INtestinal Malabsorption in Critical Illness
In the current study, we willquantitate the difference in digestion and absorption kinetics of dietary whole protein versus free amino acids in vivo in critically ill patients admitted to the intensive care unit suffering from…
- Conditions
- Intestinal Malabsorption, Critical Illness, Protein Malnutrition
- Trial name
- PANINI (NCT04791774)
- Testing
- Milk protein (food grade protein), Fee amino acids (food grade amino acids)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Maastricht University Medical Center
Indolent Lymphoma
Antiviral Agent HARVONI® for the Treatment of HCV-associated Indolent B-Cell Lymphoma
We and other investigators have revealed an association between Hepatitis C virus (HCV) seropositivity and an increased risk of developing marginal zone B-cell lymphoma (MZ), lymphoplasmacytic lymphoma (LPL, also known as…
- Trial name
- NCT03261349
- Testing
- Ledipasvir and sofosbuvir
- Volunteers
- 21 people
- Sponsor
- National Taiwan University Hospital
Amyloidosis, Basal Cell Carcinoma
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
This phase II trial studies whether providing cancer treatment in the home is preferred over the traditional clinic setting and if it improves treatment satisfaction in cancer patients living in the Florida Panhandle and…
- Conditions
- Amyloidosis, Basal Cell Carcinoma, Biliary Tract Carcinoma, Bladder Carcinoma
- Trial name
- NCT07285044
- Testing
- Cancer Therapeutic Procedure, Questionnaire Administration
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Recurrent Colon Cancer, Recurrent Rectal Cancer
Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer
The study will determine the maximum tolerated dose (MTD) of AUY922 given in combination with cetuximab in previously treated patients with KRAS wild-type metastatic colorectal cancer.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer
- Trial name
- NCT01294826
- Testing
- AUY922, Cetuximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Swedish Medical Center