Clinical trials: Protein Digestion
Psychological Phenomena and Processes, Nutrition Physiological Phenomena
The Effects of Fiber on Appetite and Digestion Hormones
In this research study, investigators are interested in how certain dietary fibers in the diet affect certain hormones released from your intestine after eating and how these influence your appetite.
- Trial name
- FS (NCT01050101)
- Testing
- No fiber, Low GI high fiber viscous meal, Low GI high fiber non-viscous
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Colorectal Cancer, Neoplasm of Uncertain Malignant Potential
Fludeoxyglucose F 18 PET Imaging in Determining Protein and Gene Expression Signatures in Patients With Premalignant Polyps or Colon Cancer
RATIONALE: Diagnostic imaging procedures, such as fludeoxyglucose F 18 PET, may be effective in detecting cancer or recurrence of cancer, or premalignant polyps.
- Trial name
- NCT00550628
- Testing
- DNA methylation analysis, fluorescence in situ hybridization, gene expression analysis
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity, Non-alcoholic Fatty Liver Disease
Protein-rich Diet and NAFLD in Bariatric Surgery
Randomized, single-blind, trial to determine whether a high-protein, low calorie diet is more effective than a control low calorie diet in improving the metabolic and histologic abnormalities in patients with Non-alcoholic Fatty…
- Trial name
- NCT02400099
- Testing
- High-protein low calorie diet, Control low calorie diet, Anthropometrical measurements
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Esophageal Adenocarcinoma, Esophageal Cancer
Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction
An open label phase II study to determine the safety and preliminary efficacy of the combination of 1-year of adjuvant trastuzumab deruxtecan and nivolumab for patients with HER2 overexpressing esophagogastric adenocarcinoma who…
- Conditions
- Esophageal Adenocarcinoma, Esophageal Cancer, HER-2 Protein Overexpression, Gastroesophageal-junction Cancer
- Trial name
- NCT05480384
- Testing
- Nivolumab, Trastuzumab deruxtecan
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Brown University
Human Immunodeficiency Virus (HIV), Hepatitis C, Chronic
The Effect of HIV Tat Protein on HCV Replication in an In-vitro Model System
Investigators in the Division of Infectious Diseases and the Departments of Biochemistry and Molecular Biology of The George Washington University Medical Center are carrying out a research study to determine why patients with…
- Trial name
- NCT01206933
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- George Washington University
Neoplasms, Lung Neoplasms
CureOne Registry: Advanced Malignancy or Myelodysplasia, Tested by Standard Sequencing and Treated by Physician Choice
Registry participants with advanced malignancy or myelodysplasia will have a sample of their tumor or tissue analysed for genetic alterations using next generation sequencing (NGS) performed in a lab that has been certified to…
- Conditions
- Neoplasms, Lung Neoplasms, Colon Neoplasms, Breast Neoplasms
- Trial name
- N1 (NCT02900248)
- Testing
- Provider determined
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- CureOne
Gastrointestinal Symptoms in Young Infants
Milk-induced Gastrointestinal Symptoms in Infants
Various digestive manifestations are common in infants less than 6 months and have a significant impact on morbidity and quality of life of the family.
- Trial name
- NCT01684319
- Testing
- Formula milk free of cow's milk protein
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Geneva
Multiple Myeloma, Non-Hodgkin Lymphoma
Music Therapy on Nausea and Pain for Autologous Stem Cell
Autologous stem cell transplant (ASCT) is an important therapy for patients with multiple myeloma, non-Hodgkin's lymphoma, and Hodgkin's lymphoma. It has been shown to improve progression free survival and overall survival.
- Conditions
- Multiple Myeloma, Non-Hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- NCT01487031
- Testing
- Music Therapy, No music therapy
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Case Comprehensive Cancer Center
Hepatitis C
Safety and Efficacy of the Therapeutic Vaccine GI-5005 Versus Placebo for the Treatment of Chronic Hepatitis C Infection
The GI-5005 therapeutic vaccine or placebo will be injected under the skin of hepatitis C virus (HCV) subjects. Patients will be monitored for safety, immune responses and any therapeutic benefits related to the injections.
- Trial name
- NCT00124215
- Testing
- GI-5005
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- GlobeImmune
FPIES, IgE Mediated Food Allergy
Quality of Life and Eating Disorders in Children With FPIES, Food Allergy or Celiac Disease
Food allergies are associated with a decrease in quality of life. Patients with FPIES often have more food avoidance than necessary. The greater the number of avoided foods, the greater the risk of eating disorders.
- Conditions
- FPIES, IgE Mediated Food Allergy, Celiac Disease
- Trial name
- QUALIM (NCT04643704)
- Where
- France
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Cancer
NC410 and FOLFIRINOX in Combination With Nivolumab With or Without Ipilimumab in Patients With Untreated Metastatic Pancreatic Cancer
The purpose of this study is to evaluate safety of the treatment regimen and identify any novel toxicities.
- Trial name
- NCT06941857
- Testing
- Oxaliplatin, Irinotecan, Folinic Acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Enteral and Supplement Feeds Adverse Reaction, Peritonitis; Acute
Enteral Nutrition in Acute Generalized Peritonitis
Hospitals in South Kivu always have problems supplying artificial enteral nutritional products because of their high cost and low availability in our areas.
- Trial name
- PAG/NUTRI (NCT05997745)
- Testing
- study group
- Volunteers
- 76 people
- Sponsor
- Université Evangélique enAfrique
Diet, Healthy, Protein; Disease
Acute Meat and Alternative Intake (PRotEin DIet SatisfacTION Trial 3)
Introduction: Protein rich foods that are alternatives to farm-grown meat have received considerable consumer attention. Whilst meat alternatives were once niche food products aimed at vegetarians, they are increasingly marketed…
- Trial name
- PREDITION (NCT04545398)
- Testing
- Food. Beef, Pasture-raised, Food. Beef, Grain-fed, Food. Meat alternative
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Pancreatic Cancer, Pancreatic Cancer Metastatic
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.
- Conditions
- Pancreatic Cancer, Pancreatic Cancer Metastatic, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- MAPKeeper 301 (NCT07562152)
- Testing
- Atebimetinib, GnP, mGnP
- Where
- 72 sites in United States, Australia and 7 more
- Volunteers
- 570 people
- Sponsor
- Immuneering Corporation
Pancreatic Cancer
QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
This is a phase 1b/2 study to evaluate the safety and efficacy of metronomic combination therapy in subjects with pancreatic cancer who have progressed on or after previous SoC chemotherapy.
- Trial name
- NCT03329248
- Testing
- ALT-803, ETBX-011, GI-4000
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- ImmunityBio, Inc.
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer
The purpose of this study is to determine the proportion of patients diagnosed with Lynch syndrome in colorectal cancer patients with the loss of staining by immunohistochemistry (IHC) of any of the mismatch repair (MMR)…
- Trial name
- NCT03047226
- Testing
- next-generation sequencing
- Where
- 7 sites in China
- Volunteers
- 311 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Digestive System
Digestibility of Fermotein™
This study aims to assess the degree of digestibility of 3 different Fermotein™ products and compare this to a reference commercially available Mycoprotein (Quorn) and to assess the effects on blood glucose and insulin levels.
- Trial name
- MyDi (NCT04819789)
- Testing
- Fermotein™ dry powder porridge, Fermotein™ wet porridge, Fermotein™ modified wet porridge
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Hepatitis C
A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial)
The purpose of this study is to investigate the safety and antibody (germ fighters) response of the experimental (investigational) vaccine against HCV when injected into the arm of healthy adults.
- Trial name
- NCT07237282
- Testing
- AVIHepC1, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Energy Intake, Metabolism
Identifying Wearable Biomarkers to Monitor Dietary Intake
Background: Measuring what people eat is a challenge in nutrition research. Traditional methods, like food diaries, rely on self-reporting of individuals, and suffer from poor accuracy and recall bias.
- Conditions
- Energy Intake, Metabolism, Digestion, Wearables
- Trial name
- FoodSense (NCT06398340)
- Testing
- High Calorie Meal Intervention, Low Calorie Meal Intervention
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London