Clinical trials: Protein Digestion
Eosinophilic Esophagitis (EoE)
Tolerability of Baked Dairy Protein in Eosinophilic Esophagitis Patients With Cow Milk Protein Trigger
Eosinophilic esophagitis (EoE) is a chronic immune mediated disease characterized by eosinophilic infiltration in esophageal epithelium and resulting in esophageal dysfunction.
- Trial name
- NCT06756581
- Testing
- baked milk product diet
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Shaare Zedek Medical Center
Blood Disease, Hepatitis, Viral, Human
Delta Hepatitis and Liver Disease in Hemophiliacs
To determine the prevalence of hepatitis delta virus (HDV) in a large cohort of hemophiliacs and to elucidate the role of HDV in the development and progression of liver disease in this population.
- Conditions
- Blood Disease, Hepatitis, Viral, Human, Hemophilia A, Liver Diseases
- Trial name
- NCT00005304
- Sponsor
- Baylor College of Medicine
Ulcerative Colitis
Pilot Study of a New Medical Food in the Management of Ulcerative Colitis
The goal of this clinical trial is to determine at how well a new medical food works in managing inflammation associated with ulcerative colitis in children.
- Trial name
- NCT06116643
- Testing
- Soluble protein hydrolysate (SPHi)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Digestive Health, Gastrointestinal Health
Effects of Microbial Protease Supplementation on Postprandial Plasma Amino Acid Concentrations and Appetite
The primary purpose of this study is to assess the effect of co-ingestion of microbial proteases and whey protein concentrate (WPC) on postprandial plasma amino acid concentrations in healthy adult participants compared to WPC…
- Conditions
- Digestive Health, Gastrointestinal Health, Appetitive Behavior
- Trial name
- NCT05957185
- Testing
- OPTIZIOME® P³ HYDROLYZER® - WHEY
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BIO-CAT, Inc.
Vasculitis, Cryoglobulinemia
Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis
Cryoglobulinemia are responsible for systemic vasculitis, and the most frequently targeted organs are the skin, joints, kidney and peripheral nervous system.
- Conditions
- Vasculitis, Cryoglobulinemia, Hepatitis C
- Trial name
- NCT02856243
- Testing
- new antiviral therapy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolism, Trauma
ImpACt of Very High Protein Content Enteral nUtrition Formulas on Critically Ill MUltipLe trAuma paTiEnts
This prospective observational randomized study aims to determine energy, protein intake and gastrointestinal tolerance while using enteral nutrition formulas with very high protein content and enteral nutrition formulas with…
- Conditions
- Metabolism, Trauma, Nutritional Deficiency, Protein Malnutrition
- Trial name
- ACCUMULATE (NCT05647135)
- Testing
- Medical food
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Surgery, Colorectal Cancer
Postoperative Electrical Muscle Stimulation Two
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity.
- Conditions
- Surgery, Colorectal Cancer, Muscle Atrophy, Cancer Gi
- Trial name
- POEMS2 (NCT06964438)
- Testing
- Neuromuscular Electrical Stimulation, Protein supplement drink
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Appendicitis Acute, Acute Abdomen in Children
The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care
BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g.
- Trial name
- ISAAK (NCT06762275)
- Testing
- Diagnostic strategy
- Where
- Netherlands
- Volunteers
- 566 people
- Sponsor
- University Medical Center Groningen
Gastrointestinal Disease
Casein Glycomacropeptide in Healthy Subjects
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- NCT02832700
- Testing
- Casein glycomacropeptide
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Pancreatitis
Activated Protein C in Severe Acute Pancreatitis
Activated protein C (APC)has been shown to reduce mortality in severe sepsis(Bernard et al. 2001b). The clinical picture of severe acute pancreatitis (AP) is similar to that of sepsis.
- Trial name
- NCT01017107
- Testing
- Activated protein C
- Where
- Finland
- Volunteers
- 32 people
- Sponsor
- Helsinki University Central Hospital
Appendicitis
Inflammatory Response in Appendicitis
Although the presence of SIRS has been described in patients with appendicitis, its progressive response related and together with progression of symptomatology from the onset of symptoms to diagnostic has not been characterized.
- Trial name
- NCT01718171
- Where
- Chile
- Volunteers
- 183 people
- Sponsor
- Cirujanos la Serena
Chronic Hepatitis B
Recombinant Human Serum Albumin/Interferon alpha2a Fusion Protein Phase Ib Study in Chronic Hepatitis B Patients
This is an open label study that will be conducted at a single site in China to evaluate the safety,tolerability and PK/PD profile of multiple dose of recombinant human serum albumin/interferon alpha2a fusion protein in chronic…
- Trial name
- NCT01997944
- Testing
- Human Serum ALbumin/interferon alpha2a, Pegasys
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Beijing Bio-Fortune Ltd.
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Stomach Distended, Bloating
Examining the Effectiveness of Digestive Enzymes at Reducing Bloating and Stomach Distension
Flatter Me is a product that includes digestive enzymes in a way to support digestion of macronutrients and their constituents and provides herbs traditionally used for digestive health support.
- Trial name
- NCT05520411
- Testing
- HUM Flatter Me
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- HUM Nutrition, Inc.
Colorectal Cancer, Hematologic Malignancy
Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer
One of the ways that cancer grows and spreads is by avoiding the immune system.NK cells are immune cells that kill cancer cells, but are often malfunctioning in people with colorectal cancer and blood cancers.
- Conditions
- Colorectal Cancer, Hematologic Malignancy, Rectum Cancer, Acute Myeloid Leukemia
- Trial name
- NCT05400122
- Testing
- Vactosertib, Fludarabine Phosphate, Cyclophosphamide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- David Wald
Chronic Heart Failure, Pulmonary Disorder, Chronic Obstructive
Method To Measure Protein Digestion & Absorption
The aim of the present study is to validate a new method in healthy volunteers and those diagnosed with COPD and CHF that is able to measure protein digestion and absorption simultaneously.
- Trial name
- NCT02065141
- Testing
- sip feeding with stable isotope infusion
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Cancer
iDentification and vAlidation Model of Liquid biopsY Based cfDNA Methylation and pRotEin biomArKers for Pancreatic Cancer (DAYBREAK Study)
DAYBREAK is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, serum protein markers, blood miRNA markers and others, in which of 450…
- Trial name
- NCT05495685
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Hepatitis A
A Efficacy Against Otitis Media in Children With 11 Valent Pneumococcal Vaccine
The purpose of this study is to assess the efficacy in young children in preventing acute otitis media due to vaccine serotype pneumococcal or non typable Hemophilus influenza, following immunization with an 11-valent…
- Trial name
- NCT00119743
- Testing
- undecavalent pneumococcal-protein D conjugate vaccine
- Where
- 41 sites in Czechia, Slovakia
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Digestive Health, Gastrointestinal Health
Effects of Omeprazole Ingestion on Postprandial Amino Acid Concentrations in Response to a Mixed Meal
Omeprazole is a proton pump inhibitor commonly used to reduce stomach acid in the treatment of heartburn, gastroesophageal reflux disease, and gastric ulcers.
- Trial name
- NCT07142486
- Testing
- Omeprazole 20 mg
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- McGill University
Neoplasms, Malignant Solid Tumors
Cancer Vaccine Targeting Brachyury Protein in Tumors
Background: Cancer vaccines are being developed to help teach the body's immune system to attack and destroy cancer cells. A new vaccine being tested targets Brachyury protein.
- Conditions
- Neoplasms, Malignant Solid Tumors, Colon Neoplasms, Adenocarcinoma
- Trial name
- NCT01519817
- Testing
- GI-6301 (Yeast Brachyury Vaccine)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)