Clinical trials: Protein Digestion
Lactose Intolerance
HYBRID: Hydrogen Breath Test in Lactose Digestion
The purpose of this study is to investigate the effect of a fermented infant formula on lactose digestion in lactose intolerant adults.
- Trial name
- HYBRID (NCT02703987)
- Testing
- Fermented infant milk formula, Non-fermented infant milk formula
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Pancreatic Cancer
R115777 in Treating Patients Who Have Metastatic Pancreatic Cancer
Phase II trial to study the effectiveness of R115777 in treating patients who have metastatic pancreatic cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005843
- Testing
- tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
HER2 Mutation-Related Tumors, HER2
A Phase 1/1b Study of IAM1363 in HER2 Cancers
This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.
- Conditions
- HER2 Mutation-Related Tumors, HER2, HER2-positive Breast Cancer, HER2 + Breast Cancer
- Trial name
- NCT06253871
- Testing
- IAM1363
- Where
- 53 sites in United States, France and 6 more
- Volunteers
- 383 people
- Sponsor
- Iambic Therapeutics, Inc
Esophageal Squamous Cell Carcinoma (ESCC)
Immunochemotherapy ± Salvage Chemoradiation for Local Recurrence of Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy
The combination of programmed death receptor 1 (PD-1) inhibitors with chemotherapy has been recognized for the treatment of advanced and metastatic esophageal squamous cell carcinoma (ESCC).
- Trial name
- ESO-Nanjing12 (NCT07016737)
- Testing
- Sintilimab Combined With Docetaxel Monotherapy
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Ye jinjun
Acute Pancreatitis
Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis
To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.
- Trial name
- DIAGNON (NCT03634787)
- Testing
- CT Scan Day 5-7
- Where
- Lithuania
- Volunteers
- 280 people
- Sponsor
- Vilnius University
Celiac Disease in Children
Intestinal Fatty Acid-binding Protein (I-FABP) Levels in Pediatric Celiac Patients
A prospective, longitudinal study meant to compare blood levels of I-FABP in pediatric celiac patients during diagnosis to levels under gluten free diet, it's correlation with traditional serology testing and questionnaire…
- Trial name
- NCT03244254
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Schneider Children's Medical Center, Israel
Pancreatic Cancer, Adenocarcinoma Pancreas
FAPi PET in Pancreatic Ductal Adenocarcinoma
Pancreatic adenocarcinoma commonly referred to as pancreatic cancer is a cancer which is known to involve the pancreas and the surrounding structures like blood vessels, which makes it an aggressive cancer.
- Trial name
- FAP-1 (NCT07342231)
- Testing
- Ga-68 FAPi PET/CT
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital
Digestive System
Degree of Digestibility of Barley Rice Proteins
This study aims to assess the degree of digestibility of barley rice protein and compare this to another sustainable, commercially available protein concentrate (pea protein), and a benchmark whey protein, and to assess the…
- Trial name
- Bar-pro (NCT05426122)
- Testing
- Barley rice protein concentrate shake, Pea protein concentrate shake, Whey protein concentrate shake
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Metabolism, Fatty Liver
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
- Trial name
- NCT00476879
- Testing
- Somatropin and pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Kidney Failure
Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function
Weight loss commonly occurs in patients with chronic kidney disease (CKD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01890811
- Testing
- Boost High Protein
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas A&M University
Gastrointestinal Stromal Tumors
DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)
This study will assess the safety, efficacy, and pharmacokinetics of DS-6157a in participants with advanced gastrointestinal stromal tumors (GIST).
- Trial name
- NCT04276415
- Testing
- DS-6157a
- Where
- 5 sites in United States, Japan
- Volunteers
- 34 people
- Sponsor
- Daiichi Sankyo
Critical Illness, Gastro Intestinal Surgery
Undiluted and Diluted Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Gastro Intestinal Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT07352150
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- John Paul II Catholic University of Lublin
Hepatitis C
HCV Virions Bound Proteins
The emergence of hepatocellular carcinoma (HCC) has prompted a search for a thorough understanding of the biology of one of its major causative agents, the hepatitis C virus (HCV).
- Trial name
- NCT02795403
- Testing
- blood draw of 150ml, twice
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Healthy
Effects of a Diet Based on Inulin-rich Vegetables on Gut Health and Nutritional Behaviour in Healthy Humans
Inulin-type fructans (ITF) are fermentable dietary fibres that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behaviour is a matter of debate.
- Trial name
- NCT03540550
- Testing
- Diet based on inulin-rich vegetables
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
CD55-deficient Protein-losing Enteropathy
Compassionate Use of Pozelimab
Provide compassionate use of pozelimab
- Trial name
- NCT05232110
- Testing
- Pozelimab
- Sponsor
- Regeneron Pharmaceuticals
Colorectal Cancer
Evaluation of Peripheral Blood Protein Biomarkers for Colorectal Cancer Screening
The aim of the study is to validate the value of value of peripheral blood protein biomarkers in colorectal cancer screening, and to identify new ones
- Trial name
- COLODIAG (NCT05520840)
- Testing
- blood sampling for screening of biomarkers
- Where
- 3 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Rouen
Chronic Hepatitis b
A Phase II Study of Subcutaneously Injected PD-L1 Antibody ASC22 in Chronic Hepatitis B Patients
The objective of this study is to evaluate the safety and efficacy of ASC22 in the treatment of chronic hepatitis B after single and multiple drug administration.
- Trial name
- NCT04465890
- Testing
- ASC22, sodium chloride
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
Colon Cancer
Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients
A prospective, randomized controlled study, using stable isotope methodology, is proposed to determine whether an oral nutrition support regimen, containing pressurized whey protein and glucose, is more effective at normalizing…
- Trial name
- NCT01222208
- Testing
- Oral Nutrition with dextrose and pressurized whey protein, Peripheral Parenteral Nutrition
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Digestive Health, Quality of Life
Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024).
- Trial name
- NCT06946017
- Testing
- Fermented dairy protein with prebiotic fiber supplement
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Emesis
High Protein Intake to Decrease Emesis and Promote Patient Satisfaction in Labor
The purpose of our study is to determine if the incidence of emesis can be lowered with the addition of a high protein drink during labor.
- Trial name
- NCT01414478
- Testing
- Protein Shake
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh