Clinical trials: Protein Metabolism
Prediabetes, Obesity
Veterans Achieving Weight Loss and Optimizing Resilience-Using Protein
Diabetes is a major health concern in obese older Veterans, especially in those who are African American. The negative impact of diabetes on muscle and physical function contributes to metabolic as well as physical decline and is…
- Trial name
- VALOR-UP (NCT03835416)
- Testing
- Foods rich in high quality protein
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Hypophosphatasia
Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP)
The aim of this study is to assess safety and efficacy of Asfotase Alfa (ALXN1215) in patients with hypophosphatasia
- Trial name
- NCT02456038
- Testing
- Asfotase Alfa (ALXN1215)
- Where
- 12 sites in Japan
- Volunteers
- 13 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Healthy Adults
Practical Approaches for Interrupting Prolonged Sitting to Improve Postprandial Glucose and Protein Metabolism
The present study will determine the impact of interrupting prolonged sitting with short, 2-minute walks or body-weight squats on: i) postprandial glycemia and insulinemia, and; ii) postprandial utilization of dietary amino…
- Trial name
- NCT03896828
- Testing
- Mixed-macronutrient meal
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Sedentary Lifestyle
Influence of Sedentary Time on Skeletal Muscle Protein Metabolism
This study will investigate the influence of increased sedentary time on long-term measures of muscle protein synthesis and metabolic health.
- Trial name
- NCT02624011
- Testing
- 7 days of habitual physical activity followed by 7 days of reduced physical activity
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Cardiovascular Diseases, Dyslipidemia
Additional KIF6 Risk Offers Better Adherence to Statins
Many patients prescribed statins to lower their cholesterol stop taking their statin over time. The purpose of this study is to determine whether providing subjects their KIF6 carrier status (associated with increased…
- Trial name
- AKROBATS (NCT01068834)
- Testing
- KIF6 genetic test
- Where
- United States
- Volunteers
- 1,282 people
- Sponsor
- Medco Health Solutions, Inc.
Vascular Calcification
Aortic Calcification and Vitamin K Antagonists
The vitamin K antagonists (VKA) are necessary drugs of prevention and treatment of thrombo-embolic disease. The AVKAL study assesses the impact of VKA treatment on the aortic calcifications development.
- Trial name
- AVKAL (NCT02823093)
- Where
- France
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio
Liver Diseases, Cirrhosis, Liver
Evaluation of a High Protein Plant Dominant Diet (HiProPlaDo) in Liver Cirrhosis
The aim of the study is to compare the implementation of a high-protein diet based on plant-based foods (Group A) with the usual guidelines for liver patients, in which protein needs are met by low-fat animal foods (Group B).
- Conditions
- Liver Diseases, Cirrhosis, Liver, Sarcopenia, Malnutrition; Cachexia
- Trial name
- HiProPlado (NCT07028580)
- Testing
- Diet based on animal proteins, Diet based on plant proteins., General instructions for patients with liver disease.
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Agricultural University of Athens
Hypophosphatasia
Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)
This Clinical Trial is being conducted to study Hypophosphatasia (HPP), a bone disorder caused by gene mutations or changes. These gene mutations cause low levels of an enzyme needed to harden bone.
- Trial name
- NCT00894075
- Testing
- ENB-0040
- Sponsor
- Alexion Pharmaceuticals, Inc.
Healthy Participants
The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protein Metabolism.
The ketone β-hydroxybutyrate (BHB) is endogenously produced during periods of low glucose availability, serving as an alternative metabolic fuel.
- Trial name
- WAKM (NCT07082309)
- Testing
- Ketone Monoester (KE) and whey protein beverage, Control
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Dietary Exposure
The Effect of Eucaloric High-Protein Fiber Diet in Healthy Adults: A Repeated Single-Arm Clinical Trial
The aims of this study is to investigate the effect of eucaloric high protein and fiber diet on healthy subjects.
- Trial name
- NCT05455164
- Testing
- Isomalto Oligosaccharide
- Where
- Indonesia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitas Katolik Widya Mandala Surabaya
Increased Metabolic Requirement, Healthy
Protein Requirements In Active Populations
Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).
- Trial name
- NCT02478814
- Testing
- Amino Acid Intake
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Nutritional Deficiency, Ileostomy; Functional Disturbance
Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Clinical trial, active comparator, cross over, randomised. In total, 12 adults with an ileostomy will be randomised to a sequential 4 weeks intervention with different qualities and sources of protein wish 2-week washout periods.
- Conditions
- Nutritional Deficiency, Ileostomy; Functional Disturbance, Short Bowel Syndrome, Absorption; Disorder, Protein
- Trial name
- ABSOLYT (NCT04141826)
- Testing
- Hydrolysed whey, Intact whey, Caseinate
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Hvas
Complication of Peritoneal Dialysis
Natural History of Mineral Metabolism Parameters and Protein-bound Toxins in Incident Peritoneal Dialysis Patients
The aims of this study are 1. To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules', and protein bound URM in…
- Trial name
- NCT01306149
- Where
- Belgium
- Volunteers
- 96 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Overweight, Obese
The Effect of Protein-enriched Diet on Body Composition and Appetite
Obesity is a major problem worldwide and current dietary interventions are not proving to be enough to cease the increase in levels of obesity and its detrimental side effects, such as nonalcoholic fatty liver disease (NAFLD).
- Conditions
- Overweight, Obese, Metabolic Syndrome, Non Alcoholic Fatty Liver Disease
- Trial name
- ProteinRich (NCT01634048)
- Testing
- High Protein, low calorie meal replacement
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Kidney Disease
Effect of Dietary Protein Source on Phosphaturia, PTH and FGF23 in Patients With CKD 3 and 4
Phosphorus is a substance in the blood that comes from food and is normally cleared from the body by the kidneys. In patients with kidney disease, excess phosphorus may build up in the body as you eat.
- Trial name
- NCT00764816
- Testing
- grain (soy) protein diet, casein (meat) protein diet
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Indiana University
Calcium Metabolism
Effect of Dietary Protein Source on Calcium Metabolism
Osteoporosis is a major health concern worldwide. While there are drugs available for the treatment and prevention of osteoporosis, they are not practical for population-wide prevention efforts.
- Trial name
- NCT00187538
- Testing
- Dietary
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Overweight (BMI > 25), Obesity (BMI>30)
Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.
The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in…
- Conditions
- Overweight (BMI > 25), Obesity (BMI>30), Hs-CRP
- Trial name
- NCT07566325
- Testing
- Avocado, Control
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Protein Metabolism
Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides
Skeletal muscle quality is an important determinant of exercise performance and overall health. It is vital for not just movement, but also metabolizing nutrients.
- Trial name
- NCT03952884
- Testing
- Resistance Exercise, No Resistance Exercise, Leucine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Refractory Multiple Myeloma
Carfilzomib in Treating Patients With Multiple Myeloma in First Relapse or Refractory to First-Line Therapy
This phase II trial studies how well carfilzomib works in treating patients with multiple myeloma in first relapse or refractory to first-line therapy.
- Trial name
- NCT02020941
- Testing
- carfilzomib, dexamethasone, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Attaya Suvannasankha