Clinical trials: Protein-Energy Malnutrition
Healthy
Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly (Fruisenior)
To develop more natural fruit pastes matrices that can effectively act as carbohydrate vectors in the elderly population and that are part of a normal diet while maintaining the pleasure of eating.
- Trial name
- Fruisenior (NCT04482530)
- Testing
- fruit paste matrice
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
CKD, Low Protein Dietary Intake
Suitability of a High-energy, Low-protein Formula (Renalive® LP)
Inclusion criteria (1) Diagnosed with chronic kidney disease stage 3b-5 (with history of eGFR<45 mL/min/1.73 m2) Exclusion criteria (1) Has received dialysis or are expected to start dialysis within the next 3 months.
- Conditions
- CKD, Low Protein Dietary Intake, Malnutrition (Calorie)
- Trial name
- NCT06892249
- Testing
- Renalive® LP,
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people
- Sponsor
- Fresenius Kabi Taiwan Ltd.
Severe Acute Malnutrition, Kwashiorkor
Effectiveness of Alternative Diets During the Stabilization Phase on Children With Complicated SAM
Severe acute malnutrition (SAM) is a life threatening condition and is defined by 1) a weight-for-height Z-score more than three standard deviations (SD) below the median based on the 2006 World Health Organization (WHO) growth…
- Conditions
- Severe Acute Malnutrition, Kwashiorkor, Nutritional Edema, Marasmus
- Trial name
- NCT05020847
- Testing
- Standard F75, Alternative F75 with CMV, Alternative F75 without CMV
- Where
- Burkina Faso
- Volunteers
- 297 people
- Sponsor
- University Ghent
Buprenorphine, HIV
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Buprenorphine, HIV, Drug Abuse, Drug Addiction
- Trial name
- BELIEVE (NCT00798538)
- Testing
- Services will be provided at one site, Services remain dispersed; i.e., not centralized to one-location or provider.
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Malnutrition
Effect of Energy- and Protein-rich Foods on Physiological Functions and Quality of Life in Undernourished Patients
The purpose of this study is to determine whether individualised nutritional therapy comprised of appetising, energy- and protein-rich foods can have a positive effect on physiological function and quality of life of…
- Trial name
- NCT01240031
- Testing
- Individualised nutritional therapy, Usual nutrition care
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Copenhagen
Malnutrition, Sarcopenia
Malnutrition and Sarcopenia in Adults With Chronic Kidney Disease in Tunisia
The TUN-CKDN study is a national, multicenter, prospective cohort study conducted in nephrology centers in Tunisia. It aims to describe how often malnutrition and sarcopenia (loss of muscle strength and muscle mass) occur in…
- Conditions
- Malnutrition, Sarcopenia, Renal Insufficiency, Chronic
- Trial name
- TUN-CKDN (NCT07906405)
- Testing
- Standardized nutritional and muscle assessment
- Where
- Tunisia
- Volunteers
- 4,000 people
- Sponsor
- Dacima Consulting
Elderly Patients
Citrulline, Exercise Training and Muscle Strength in the Elderly
The aim of this study is to assess the effect of citrulline supplementation on muscle strength in elderly institutionalized subjects undergoing a resistance exercise training program.
- Trial name
- CITREX (NCT01599676)
- Testing
- Citrulline, Non essential amino acid
- Where
- France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Military Operational Stress Reaction, Malnutrition (Calorie)
Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training
Soldiers commonly lose muscle mass during training and combat operations that produce large energy deficits (i.e., calories burned > calories consumed).
- Conditions
- Military Operational Stress Reaction, Malnutrition (Calorie), Weight Loss, Muscle Wasting
- Trial name
- NCT05210205
- Testing
- EAA, Energy Dense, Control
- Where
- Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Radiculopathy, Myelopathy
PCM Cervical Disc System
The PCM Cervical Disc was studied in a prospective, multicenter, randomized FDA-approved investigational device exemption (IDE) clinical trial conducted in the United States to evaluate longitudinal outcomes over 2 years…
- Trial name
- NCT00578812
- Testing
- Anterior Cervical Discectomy and Fusion (ACDF), PCM Cervical Disc
- Where
- 23 sites in United States
- Volunteers
- 494 people
- Sponsor
- NuVasive
Changes in Gut Microbiota Bifidobacterial Levels
Effect of an Oral Nutritional Supplement (ONS) with Prebiotic Fibre Compared to a Non-fibre Containing ONS Equal in Energy and Protein Content on Gut Microbiota in Older Adults with or At Risk of Disease Related Malnutrition
This study assesses the effects of an oral nutritional supplement (ONS) with fibre compared to a non-fibre containing ONS equal in energy and protein content on gut microbiota bifidobacteria in older adults with or at risk of…
- Trial name
- BISON (NCT06645171)
- Testing
- Fibre drink
- Volunteers
- 62 people
- Sponsor
- Nutricia Research
Protein-Energy Malnutrition, Kidney Failure, Chronic
Egg Albumin-Based Protein Supplement Versus Renal-specific Supplement in Hemodialysis Patients
Malnutrition is seen frequently in hemodialysis units in most developing countries. Malnutrition increases morbidity and mortality in this population and its treatment improves patient survival and health status The purpose of…
- Conditions
- Protein-Energy Malnutrition, Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT01981083
- Testing
- Egg albumin-based protein supplement, Renal-specific oral supplement
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Centro Medico Lic Adolfo Lopez Mate
Congenital Heart Disease in Children, Post-cardiac Surgery
To Assess the Efficacy of Early Administration of Energy Enriched and Protein Enriched Formula in Post Cardiac Repair Infants: a Randomized Controlled Trial, Comparative Study
Congenital heart disease (CHD) is a public health problem, A substantial percentage of infants and toddlers with CHD undergo cardiopulmonary bypass surgery.
- Conditions
- Congenital Heart Disease in Children, Post-cardiac Surgery, Malnutrition, Infant
- Trial name
- NCT05826769
- Testing
- Energy- Protein Enriched Nutritional Formula
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
ICU Acquired Weakness, Muscle Atrophy
Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )
Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay.
- Conditions
- ICU Acquired Weakness, Muscle Atrophy, Energy Malnutrition Protein, Quality of Life
- Trial name
- NCT05919940
- Testing
- Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization
- Where
- 4 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Malnutrition, Child
Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition
Malnutrition is a clinical-social disease caused by multiple prenatal, intrauterine and postnatal factors as well as social, political and cultural determinants (distal causes).
- Trial name
- NCT03355313
- Testing
- Low level Light therapy
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Undernutrition
Microbiota and Protein-energy Wasting (MIDIWA)
Oral supplementation with branched chain amino acids (BCAA) increases the levels of circulating BCAA, stimulates BCAA uptake in muscles, and decreases amino acid release from muscle, eventually promoting muscle anabolism.
- Trial name
- MIDIWA (NCT02962089)
- Testing
- Branched chain amino acids (BCAA)
- Where
- 5 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Geneva
Kwashiorkor, Marasmus
Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition
To test whether a ready-to-use therapeutic food (RUTF) enriched with polyunsaturated fatty acids (RUTF-P) is as effective for the treatment of severe acute malnutrition (SAM) as standard RUTF.
- Trial name
- NCT02053857
- Testing
- RUTF, RUTF-P, Amoxicillin
- Where
- Malawi
- Volunteers
- 141 people
- Sponsor
- Washington University School of Medicine
Dementia, Dementia, Mild
Chocolate and Physical Exercise to Reduce Malnutrition in Pre-dementia Aged People
We hypothesize that the antioxidant and cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols and physical activity may help prevent the age-dependent decline of mitochondrial…
- Conditions
- Dementia, Dementia, Mild, Dementia Moderate, Dementia Senile
- Trial name
- Choko-AGE (NCT05343611)
- Testing
- Combination of High Protein Diet and Physical Exercise protocol, HPP Choko, HPP/VE Choko
- Where
- 4 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Massimo Venturelli, PhD
Small for Gestational Age at Delivery, Low Birth Weight
Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.
The 2016 WHO antenatal care guidelines stated that pregnant women in undernourished populations should receive fortified balanced energy-protein (BEP) supplements to reduce the risk of stillbirth and small-for-gestational-age…
- Conditions
- Small for Gestational Age at Delivery, Low Birth Weight, Prematurity, Infant Malnutrition
- Trial name
- MISAME-3 (NCT03533712)
- Testing
- Fortified balanced energy-protein (BEP) supplement, Fe and folic acid supplement
- Where
- Burkina Faso
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University Ghent
Stroke, Hypoalbuminemia
Brief Title: The Role of Nutrition in the Rehabilitation of Patients With Eating Disorders After a Vascular Stroke.
Brief Summary: The main objective of this thesis is to investigate the role of nutrition - specifically the administration of protein supplements (single dose and double dose) - in the rehabilitation of stroke patients with low…
- Conditions
- Stroke, Hypoalbuminemia, Sarcopenia, Osteopenia
- Trial name
- Nutristroke (NCT06961825)
- Testing
- Dietary Supplement
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Ioannina
Protein Deficiency, Training Group, Sensitivity
Effects of a Pre-Workout on Performance, Perceptual Responses, Energy Feelings and Muscular Properties, After a Training Microcycle in Adults.
The investigation will be conducted as a double blinded, randomized, crossover within-participant comparison design with two 1-week intervention periods separated by 2-weeks for wash out, recovery, period.
- Conditions
- Protein Deficiency, Training Group, Sensitivity, Fatigue, Muscular Atrophy
- Trial name
- NCT04147741
- Testing
- Pre-Workout Supplement, Resistance Training, Endurance Training
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Greenwich