Clinical trials: Proteinuria
IgA Nephropathy
Study of BHV-1400 in IgA Nephropathy
The purpose of this study is to determine if BHV-1400 is a safe and tolerable treatment in participants with IgA Nephropathy (IgAN).
- Trial name
- NCT07054684
- Testing
- BHV-1400
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 20 people
- Sponsor
- Biohaven Therapeutics Ltd.
Diabetic Nephropathies
Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy
This study was designed to assess the efficacy of adding pentoxifylline to losartan in comparison with increasing dose of losartan in type 2 diabetes patients with nephropathy.
- Trial name
- NCT03006952
- Testing
- Pentoxifylline, Losartan
- Where
- Iran
- Volunteers
- 59 people
- Sponsor
- Tehran University of Medical Sciences
Referral and Consultation, Glomerulonephritis
Optimizing Referral Pathways for Patients With Hematuria and Moderate-Severe Proteinuria
The purpose of the study is to evaluate prospectively the impact of an electronic health record (EHR) alert on primary care providers' (PCP) referral to Nephrology of Geisinger patients with high risk signs (blood and protein in…
- Conditions
- Referral and Consultation, Glomerulonephritis, Hematuria, Proteinuria
- Trial name
- NCT07431931
- Testing
- Electronic Health Record alert
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Geisinger Clinic
IgA Patients, Hydroxychloroquine
A Study of Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy
The investigators study will recruit IgA nephropathy patients with proteinuria range from 0.75 to 3.5g/d even after three-month treatment by sufficient ACEi/ARB.
- Trial name
- NCT02942381
- Testing
- Hydroxychloroquine Sulfate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Diabetic Nephropathies, Proteinuria
N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
The study is designed to test if the combination of two potent antioxidant nutritional supplements, N-acetylcysteine and the milk thistle extract silibin, is capable of correcting the shedding of urine protein, the oxidative…
- Conditions
- Diabetic Nephropathies, Proteinuria, Oxidative Stress
- Trial name
- NCT00915200
- Testing
- N-acetylcysteine, silibin, high-dose silibin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Kidney Insufficiency, Angiotensin-Converting Enzyme Inhibitors
Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
The purpose of this study is to determine whether fosinopril and losartan are effective in the treatment of patients with Chronic Kidney Disease(CKD) stage 3.
- Conditions
- Chronic Kidney Insufficiency, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Type 1 Receptor Blockers, Proteinuria
- Trial name
- FLIP (NCT00565396)
- Testing
- Fosinopril and Losartan
- Where
- 26 sites in China
- Volunteers
- 400 people
- Sponsor
- Shanghai Municipal Health Bureau
Chronic Kidney Disease, Proteinuria
HMG-CoA Reductase add-on in Chronic Kidney Disease Patients With Proteinuria
This study is to evaluate the renal function of HMG-CoA reductase add-on in chronic kidney disease patients with proteinuria.
- Trial name
- NCT03550859
- Testing
- Telmisartan/Rosuvastatin 40/10mg, Telmisartan 40mg
- Where
- 16 sites in South Korea
- Volunteers
- 374 people
- Sponsor
- Yuhan Corporation
Preeclampsia, Hypertension
Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers
Preeclampsia (Pre-E) is a hypertensive disease of pregnancy with multi-system involvement that usually occurs in the second half of pregnancy. Pre-E occurs in 5% to 7% of U.S. pregnancies, and is the third-leading cause of U.S.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Thrombocytopenia
- Trial name
- NCT02780414
- Where
- 20 sites in United States
- Volunteers
- 1,730 people
- Sponsor
- Progenity, Inc.
Chronic Kidney Disease, Diabetic Nephropathy
A Study of Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors
The study objective is to investigate the effects of three low doses of atrasentan on urinary albumin/creatinine ratio (UACR) levels in subjects with Type 2 diabetic nephropathy.
- Trial name
- NCT00920764
- Testing
- 0.25 mg Atrasentan QD, 0.75 mg Atrasentan QD, 1.75 mg Atrasentan QD
- Where
- 28 sites in United States, Puerto Rico
- Volunteers
- 92 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Acute Kidney Injury
Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI
Animal and human studies have shown that the administration of vitamin B3 (niacin) improves renal ischemia; helping to recover from acute kidney injury (AKI) more effectively; Therefore, its use in patients with AKI could improve…
- Trial name
- VIBAKI (NCT04893733)
- Testing
- Vitamin B Complex, STOP AKI protocol
- Where
- Bolivia
- Volunteers
- 260 people
- Sponsor
- Caja Nacional de Salud
Kidney Transplant; Complications
The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
EFFEKTOR is a vanguard, multicenter, phase 2 randomized, double blinded, placebo controlled clinical trial to determine the feasibility, tolerability, safety, and efficacy of finerenone in kidney transplant recipients (KTRs).
- Trial name
- NCT06059664
- Testing
- Finerenone Oral Tablet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes, Overt Diabetic Nephropathy
Effects of Rosiglitazone on Renal Hemodynamics and Proteinuria of Type 2 Diabetic Patients With Renal Insufficiency Due to Overt Diabetic Nephropathy
Objective: To evaluate how rosiglitazone does influence the renal plasma flow, the glomerular filtration rate and the degree of proteinuria in type 2 diabetic patients with renal insufficiency due to overt diabetic nephropathy.
- Trial name
- NCT00324675
- Testing
- Rosiglitazone
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Technische Universität Dresden
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System
The main purpose of the study is find whether the addition of aldosterone antagonist, spironolactone to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II…
- Trial name
- NCT00528385
- Testing
- Spironolactone (Spironol) 25 mg
- Sponsor
- Medical University of Gdansk
Fabry Disease
Open Label Extension Study of 1 mg/kg Pegunigalsidase Alfa Every 2 Weeks in Patients With Fabry Disease
The objective of CLI-06657AA1-04 (formerly PB-102-F60) was to evaluate the long-term safety, tolerability, and efficacy parameters of 1 mg/kg pegunigalsidase alfa administered intravenously every other week in adult Fabry…
- Trial name
- NCT03566017
- Testing
- pegunigalsidase alfa
- Where
- 30 sites in United States, Australia and 11 more
- Volunteers
- 97 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Membranous Nephropathy
To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN)
The purpose of this study is to assess the efficacy of TW compared to Valsartan in treatment of heavy proteinuria of membranous nephropathy.
- Trial name
- NCT00518219
- Testing
- TW
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Nanjing University School of Medicine
Cardiovascular Disease
Renal Insufficiency And Cardiovascular Events
Reduced glomerular filtration rate (GFR) has been recently shown to be a powerful predictor of cardiovascular morbidity and mortality in the general population, independent of traditional cardiovascular risk factors.
- Trial name
- RIACE (NCT00715481)
- Where
- 20 sites in Italy
- Volunteers
- 15,628 people
- Sponsor
- Diabetic Nephropathy Study Group
Proteinuria
Availability Study of ACTH to Treat Children SRNS/SDNS
Primary nephrotic syndrome(NS) is a common children renal disease.About 20% primary nephrotic syndrome are steroid-dependent and steroid-resistant.Low serum cortisol is one of the main relapse reasons.Adrenocorticotropic…
- Trial name
- NCT02972346
- Testing
- ACTH
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Kidney Failure, Chronic
Inhibition of Aldosterone in Patients With Chronic Renal Disease
The purpose of this study is to examine whether the inhibition of aldosterone will result in lower excretion of protein via urine.
- Trial name
- NCT00430924
- Testing
- Eplerenone
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Lene Boesby
SGLT 2 Inhibitors, Pediatric Kidney Disease
Efficacy and Safety of Dapagliflozin in Children With Proteinuria
This interventional study investigates the efficacy of dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, in pediatric patients with renal disease.
- Conditions
- SGLT 2 Inhibitors, Pediatric Kidney Disease, Proteinuric Diseases, Dapagliflozin (Forxiga)
- Trial name
- NCT07204743
- Testing
- Dapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy
- Where
- Palestinian Territories
- Volunteers
- 10 people
- Sponsor
- Al-Quds University
Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease (Stages 4 and 5)
Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease
Outcome of use of a novel Modulator of Oxidative Phosphorylation on kidney function in patients with Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease (Stages 4 and 5), Proteinuria
- Trial name
- NCT07150338
- Testing
- QRX-3, Eseronate
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Neukidney Inc.