Clinical trials: Proteome
Allergic Rhinoconjunctivitis
Nasal Mucus Proteome and Immunotherapy
Nasal mucus as first line defense barrier of the nasal mucosa contains a variety of proteins that act as functional units. We recently showed that the nasal mucus proteome between allergic rhinitis patients and healthy controls…
- Trial name
- NCT02159404
- Testing
- Immunotherapy
- Where
- Austria
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Glioblastoma Multiforme, Angiogenesis
Application of Proteome Profiler Antibody Arrays to Find Angiogenetic Predictors in Glioma Paitents.
Bevacizumab has become the standard of care of recurrent glioblastoma based on promising clinical trial results with with response rates up to 50% and progression-free survival up to 9 months.
- Trial name
- NCT03225963
- Testing
- Chemoradiation with temozolomide
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Hypertrophy, Physiologic Hypertrophy
Beta2-adrenergic Agonism and Muscle Remodelling
The study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and…
- Conditions
- Hypertrophy, Physiologic Hypertrophy, Physical Activity
- Trial name
- NCT03565302
- Testing
- Formoterol, Terbutaline
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Ventricular Dysfunction, Left
Characterization of the Plasma Proteome Following Left Ventricular Assist Device Implantation
The purpose of this study is to characterize changes in the plasma proteome over time following left ventricular assist device (LVAD) implantation.
- Trial name
- NCT02428894
- Testing
- LVAD
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Aging
Protein Quantity and Quality in Older Subjects
After the age of ~50, humans start to lose muscle mass at a rate of about 1-3% per year. However, the loss of muscle mass beyond a certain point can make it increasingly difficult to perform activities of daily living such as…
- Trial name
- NCT05301179
- Testing
- Protein quantity and quality
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
COPD
Functional Proteomics of Alveolar Macrophages
The purpose of this study is to obtain young white blood cells (monocytes) from the investigators donated blood for research into how these cells change into large, mature white blood cells (macrophages) and how smoking causes…
- Trial name
- NCT00806091
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Chronic Atrophic Gastritis
Multi-omics Analyses on Etiology and Early Detection of Stomach Cancer Precursor Lesions
The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer precursor lesions.
- Trial name
- NCT06267703
- Testing
- Metabolomic profiling
- Where
- Sweden
- Volunteers
- 12,599 people
- Sponsor
- Karolinska Institutet
Proteome
Comparison of Endometrial Protein Profile in Spontaneous Versus Stimulated Menstrual Cycles in Poor Responders
Evaluation of endometrial protein profile in spontaneous and stimulated menstrual cycles
- Trial name
- NCT06804174
- Testing
- use of gonadotropins
- Where
- Slovenia
- Volunteers
- 15 people
- Sponsor
- University Medical Centre Ljubljana
Red Blood Cell, Peripheral Blood Mononuclear Cell
Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells
The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of…
- Conditions
- Red Blood Cell, Peripheral Blood Mononuclear Cell, Endothelial NO-synthase
- Trial name
- NCT02272530
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Ageing Well
A Pilot Study on Skeletal Muscle Proteome Dynamics in Younger and Older Men Undertaking Normal Activity or Resistance Exercise Training.
The goal of this basic research study is to investigate effect of resistance exercise on the quality of muscle proteins in younger and older men.
- Trial name
- LHMA Pilot (NCT07473297)
- Testing
- Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Inflammatory Disease
Study of the Proteome and Cytokines During Inflammatory Syndromes of Different Etiologies.
The hypotheses of our research are based on the fact that various pathological states, infection, cancer, inflammatory disease, can induce an inflammatory syndrome, through different pathways, even though the clinical…
- Trial name
- Proteome (NCT01903642)
- Testing
- proteomic analysis
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Renal Cell Cancer
Urine Proteome of Surgical Patients and Healthy Volunteers
The purpose of this study is to define early urinary biomarkers for diagnosis and prognosis of Renal Cell Carcinoma (RCC) with subsequent development of reliable, cost-effective, screening techniques.
- Trial name
- UP (NCT01538823)
- Where
- United States
- Volunteers
- 664 people
- Sponsor
- Washington University School of Medicine
Uveitis, Vasculitis
The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
This study will examine the proteins of people with uveitis, or inflammation of the eyes. Evaluating the vitreous, the colorless transparent substance that fills the eyeball in back of the lens, is now possible with the use of…
- Conditions
- Uveitis, Vasculitis, Ocular Inflammatory Disease
- Trial name
- NCT00331331
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- National Eye Institute (NEI)
Intensive Meditation in Novice and Experienced Meditators
Integrating Magnetic Imaging With Rich Phenotypes
This study will be focused on assessing the molecular, physiological, neuroimaging, and emotional correlates of a week-long intensive meditation retreat experience in a 20-person cohort comprised of healthy participants.
- Trial name
- IMAGINE (NCT06615531)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Tobias Moeller-Bertram
Asthma, Eosinophilic Asthma
Effect of Mepolizumab on Severe Eosinophilic Asthma
Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab.
- Trial name
- EMESEA (NCT04641741)
- Testing
- Mepolizumab 100 MG
- Where
- 5 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinico Universitario de Santiago
Obesity
The Function and Proteome Alteration of HDL Subclass After Aerobic Exercise
Obesity is one of the most important risk factors for cardiovascular disease (CVD). HDL protein composition can be altered without a change in cholesterol content.
- Trial name
- NCT04294238
- Testing
- Aerobic exercise
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Inflammatory Bowel Syndrome
Effect of Daily Consumption of Glycomacropeptide on Gut Microbiome and Blood Functional Proteome of Subjects With Irritable Bowel Syndrome
This study investigates the use of glycomacropeptide (GMP) as a means to manipulate the gut microbiome, metabolome and protein profile of subjects with irritable bowel syndrome (IBS).
- Trial name
- NCT05482464
- Testing
- Casein glycomacropeptide (CGMP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon State University
Critically Ill Surgical Patients
Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays
Background: Propofol is a drug that helps people fall asleep quickly and stay asleep during surgery, so they do not feel any pain.
- Trial name
- NCT07295795
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Surgery
Urine Proteome of Patients Having Surgery
The investigators are measuring novel proteins in the urine of patients having surgery.
- Trial name
- NCT00851994
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Washington University School of Medicine
Preeclampsia
EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)
The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs.
- Trial name
- NCT06249178
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ohio State University