Clinical trials: Proteome
Preeclampsia
Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia
The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly understood pathophysiology of preeclampsia.
- Trial name
- NCT00719654
- Where
- United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Hypertension, Renal Denervation
The Predictive Role of Proteomics in Blood Pressure Response of Hypertensive Patients Undergoing Renal Denervation.
Renal sympathetic nervous activity plays a crucial role in the development and maintenance of hypertension (HTN). Renal denervation (RDN) is a minimally invasive catheter-based treatment using mainly radiofrequency or ultrasound…
- Conditions
- Hypertension, Renal Denervation, Proteomics
- Trial name
- PREDICT-RDN (NCT06208501)
- Testing
- Urine sample for proteomic analysis, ABPM, OBPM
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Hippocration General Hospital
Type 2 Diabetes Mellitus (DM)
Proteome-Wide Association and LLM-Based Prioritization of Type 2 Diabetes Protein Targets
Type 2 diabetes is a common condition in which the body has difficulty controlling blood sugar. This study will use existing genetic, protein, and health data from prior research studies to identify blood proteins that may play a…
- Trial name
- LAUNCH-T2D (NCT07832656)
- Volunteers
- 31,994 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Gut Microbiome
Fiber Blends and Gut Microbiota (FB)
The purpose of this research study is to determine whether consuming snacks containing different blends of dietary fibers alters the type and number of bacteria found in your gut and improves markers of overall health.
- Trial name
- FB (NCT04101344)
- Testing
- Two fiber-blend snack and four fiber-blend snack
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cardiovascular Disease
The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome
Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout.
- Trial name
- NCT00445614
- Testing
- Effects of trout on CVD risk markers and plasma proteome
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Eye Disease
Analysis of Human Tear Proteins in Children
The significance of our study is in the importance of understanding the quality and quantity of proteins in the human tear film, and any unique aspects of tears in children.
- Trial name
- NCT00473278
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Down Syndrome
Correlations Phenotype / Genotype in Down Syndrome
The purpose of this study is to correlate phenotype and genotype of Down syndrome patients in order to identify the biochemical reactions involved in their mental retardation and their other phenotypic characteristics.
- Trial name
- INTREPID (NCT01034280)
- Where
- France
- Volunteers
- 524 people
- Sponsor
- Institut Jerome Lejeune
Periodontal Diseases
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
The quantification of the proteomes : L-plastin, lipocalin and adiponectin was analysed in the subgingival tissue samples of generalized severe chronic periodontitis patients with and without diabetes mellitus.The demographic and…
- Trial name
- NCT03391349
- Volunteers
- 70 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Cardiovascular Disease, Coronary Heart Disease
Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome
Background: Heart disease is the leading cause of death and disabilities in the United States. Diets high in fruits and vegetables may reduce the risk of heart disease.
- Conditions
- Cardiovascular Disease, Coronary Heart Disease, Aging
- Trial name
- NCT02379403
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Small-cell Lung Cancer
The Predictive Value of Proteome Profiling for Brain Metastasis in Limited-Stage Small-Cell Lung Cancer
This study aims to evaluate the predictive value of proteome profiling for brain metastasis in limited-stage small-cell lung cancer
- Trial name
- NCT06483919
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Jinming Yu
Normal Pressure Hydrocephalus
Cerebrospinal Fluid Proteome in Hydrocephalus
PROLIPHYC is a collaborative prospective study that aims at discovering deep cerebrospinal fluid (CSF) proteome with a new clinically-compatible proteomics strategy, in a cohort of 100 patients suspected of neurodegenerative…
- Trial name
- PROLIPHYC (NCT02016352)
- Testing
- patient CSF extraction with hydrocephalus, witness CSF extraction
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Healthy, Skeletal Muscle Atrophy
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage.
- Conditions
- Healthy, Skeletal Muscle Atrophy, Skeletal Muscle Hypertrophy
- Trial name
- NCT06350591
- Testing
- Immobilization, Resistance training
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen's University