Clinical trials: Proteomics
Acute Respiratory Failure, Critical Illness
Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.
- Trial name
- NCT06189924
- Testing
- Proteomic analysis of exhaled breath condensate
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Sports Drug Abuse
The Effect of Micro-doses Erytropoietin on Exercise Capacity in Male and Females
Recombinant human erythropoietin (rHuEPO) regimen enhances maximal oxygen consumption (VO2max), but the effect of micro-doses on maximal and submaximal performance is not clear and detection of micro-doses is difficult with…
- Trial name
- NCT04965961
- Testing
- EPO, Control group - saline injection
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- University of Copenhagen
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Peri-implant Mucositis, Peri-Implantitis
Metabolomic and Proteomic Fingerprinting in Peri-implant Diseases
Due to the limited efficacy of its treatment modalities, there is a stringent need to improve the prevention and early diagnosis of peri-implantitis.
- Trial name
- NCT04283903
- Testing
- PICF
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad Complutense de Madrid
Kidney Transplantation, Graft Rejection
Mass Spectrometry-based Proteomics in Microvascular Inflammation Diagnosis in Kidney Transplantation.
Microvascular inflammation, the hallmark histological criteria of antibody-mediated rejection in kidney transplantation, remains an issue in routine practice, due to a lack of reproducibility in its recognition by pathologists…
- Conditions
- Kidney Transplantation, Graft Rejection, Humoral Immunity, Proteomics
- Trial name
- TranSpec (NCT04851145)
- Testing
- Mass spectrometry-based proteomics of FFPE biopsies and urine samples
- Where
- 3 sites in France
- Volunteers
- 141 people
- Sponsor
- University Hospital, Bordeaux
Liver Diseases
DILIN - Prospective Study
The purpose of this study is to identify individuals who have suffered a liver injury arising as an idiosyncratic reaction to a prescription drug or a complementary and alternative medicine.
- Trial name
- NCT00345930
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopia, Healthy
Proteomic Analysis on Myopic Children Using Orthokeratology Lenses With Good or Poor Myopic Control
The key objective of the study is to gain an understanding of the biochemical processes that contribute to orthokeratology lenses being more effective in specific individuals compared to others.
- Conditions
- Myopia, Healthy, Orthokeratology
- Trial name
- ProMOC (NCT06647472)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Vejle Hospital
Respiratory Inflammation
Exploring Biomarkers in the Heat and Moisture Exchange Filters
When patients undergo major surgery, they are connected to a ventilator during anesthesia. A heat and moisture exchange filter (HME filter) is routinely placed in the ventilator tubing to ensure that the inhaled air is warm and…
- Trial name
- HMEPRO (NCT07607977)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aalborg University Hospital
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Breast Cancer
NSABP Biospecimen Discovery Project
This study is a biospecimen discovery project that will serve as a pilot for a comprehensive 'omics approach using fresh core biopsy tissue and blood samples for DNA and protein analysis, as well as paired tumor-normal exome DNA…
- Trial name
- NCT01850628
- Testing
- Paclitaxel, trastuzumab, pertuzumab
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- NSABP Foundation Inc
Prostate Cancer
Study in Predicting Outcome of Patients Undergoing Radiation Therapy for Prostate Cancer
RATIONALE: Proteins found in blood and urine samples may help predict outcome and allow doctors to plan more effective treatment.
- Trial name
- NCT00045331
- Testing
- proteomic profiling
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Acute Coronary Syndrome
Function of High Density Lipoproteins in Acute Coronary Syndromes
High density lipoproteins (HDL) have many effects that protect against cardiovascular diseases. In an acute heart attack (acute coronary syndrome -ACS), HDL change in composition and structure, reflecting the inflammatory…
- Trial name
- HDL_ACS (NCT01278875)
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cirrhoses, Liver, Hepatic Encephalopathy (HE)
Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE)
The objective of this observational study is to compare the differences in proteomics and gut microbiome between the liver cirrhosis group without hepatic encephalopathy and the hepatic encephalopathy group through proteomics and…
- Trial name
- NCT07150195
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Adult, Fatigue
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals.
- Trial name
- NCT03800342
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- George Mason University
Polycystic Ovary Syndrome, Normal Volunteers
Proteomics & Glyco-Proteomic Analysis of Follicular Fluid
To the best of the investigators knowledge, exhaustive characterization of the low and high abundant proteins and glyco-proteins of the Follicular Fluid (FF) has not yet been achieved.
- Trial name
- NCT01487486
- Testing
- IVF Antagonist Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Breast Cancer, Ovarian Cancer
Investigating the Diagnostic Potential of Tear Proteins in Cancer - A Pilot Study
This Pilot Study is to investigate the tear proteins in a multitude of cancer types and indulge in biomarker discovery to manufacture simple, accurate, and novel tear-based diagnostic tests.
- Conditions
- Breast Cancer, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer
- Trial name
- NCT05223218
- Testing
- Schirmer strip, a Class I Medical Device typically used to test for dry eye.
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Namida Lab
Urothelial Carcinoma, Bladder Cancer
Urothelial Cancer Tumor Bio-markers and Physical-spectroscopic Characteristic
Our multicenter observational study is a non-profit prospective study. The study was born from the Amplitude Project, which comprise the SOD of Minimally Invasive Robotic Urological Surgery and Renal Transplants of AOU Careggi…
- Conditions
- Urothelial Carcinoma, Bladder Cancer, Urothelial Neoplasm, Urothelial Carcinoma Bladder
- Trial name
- NCT04770974
- Testing
- Biomarkers and proteomics
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Florence
Coronary Arterial Disease (CAD)
Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions
The presence and clinical evolution of coronary atherosclerosis depend on various classic risk factors and biomarkers. However, the search for more specific markers is necessary, especially for individuals with non-obstructive…
- Trial name
- PROTEODAC (NCT06900270)
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Apoptosis, Apoptosis Regulatory Proteins
Genomic and Proteomic Analyses of Apoptosis Mechanisms in Diseased Peri-implant Tissue
A total of 72 individuals were included in the study: 23 with peri-implant mucositis, 25 with peri-implantitis, and 24 healthy controls.
- Conditions
- Apoptosis, Apoptosis Regulatory Proteins, Proteases, Peri-Implantitis and Peri-implant Mucositis
- Trial name
- NCT06865976
- Testing
- Non-Surgical Intervention, Surgical peri-implant therapy, Second stage surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Lymphoma, Lymphoid Hyperplasia
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins
BACKGROUND: Lymphomas are comprised of a diversity of tumors with different pathologic and clinical features. While distinct differences in gene expression profiles have been elucidated in different lymphomas, there has been…
- Trial name
- NCT01563874
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)