Clinical trials: Protocol Optimization
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Diseases
- Trial name
- OPTICAP (NCT02533869)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic Trial
Acute malnutrition is a condition that affects more than 45 million children under the age of five at any time and requires specific treatment to ensure patient survival.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Acute Malnutrition, Severe
- Trial name
- NCT06594341
- Testing
- Visit frequency, Suppression of the transition period, Simplified treatment
- Where
- Mali
- Volunteers
- 6,249 people
- Sponsor
- International Rescue Committee
Waldenstrom Macroglobulinaemia, Multiple Myeloma
BLOOD-dose: A Platform Trial Evaluating Dose Optimization in Hematological Diseases.
BLOOD-dose is a multicentre, adaptive, randomized, multidomain platform trial designed to optimize treatment dosing strategies in adult patients with haematological diseases.
- Trial name
- BLOOD-dose (NCT07474961)
- Testing
- teclistamab OR talquetamab OR elranatamab OR linvoseltamab, BTK inhibitors (ibrutinib and zanubrutinib)
- Where
- 5 sites in Denmark
- Volunteers
- 400 people
- Sponsor
- Anne Louise Tølbøll Sørensen
Myocardial Infarction, Acute
RAPID-POP a Randomized Controlled Trial
Efficacy of the Pressure Optimization Protocol (POP) versus Conventional Stent Deployment Strategy during Primary PCI: An Open Label Randomized Clinical Trial The investigators will compare conventional rapid stent…
- Trial name
- NCT06430892
- Testing
- Primary Percutaneous Coronary Intervention (PPCI)
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Ovarian Cancer
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Ovarian cancer is a lethal disease with an estimated 310,000 new cases and 200,000 deaths experienced worldwide in 2020. The purpose of this study is to assess the adverse events and change in disease activity of mirvetuximab…
- Trial name
- FLORENZA (NCT07059845)
- Testing
- Mirvetuximab Soravtansine, Bevacizumab, Carboplatin
- Where
- 86 sites in United States, Australia and 6 more
- Volunteers
- 400 people
- Sponsor
- AbbVie
Heart Failure, Acute Heart Failure
Protocol of Diuretics Use in Congestive Therapy in Heart Failure
The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.
- Conditions
- Heart Failure, Acute Heart Failure, Chronic Heart Failure
- Trial name
- ProDUCT-HF (NCT03892148)
- Testing
- Furosemide, Hydrochlorothiazide
- Where
- 9 sites in France
- Volunteers
- 299 people
- Sponsor
- University Hospital, Clermont-Ferrand
Polypharmacy
Pharmacological Optimization by a Specialized Outpatient Consultation Team
Background Polypharmacy is a common condition among older adults and is a major issue of concern for its association with adverse drug reactions and adverse health outcomes, including falls, functional and cognitive impairment…
- Trial name
- NCT05408598
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Fundacion Miguel Servet
Heart Disease
Bone Marrow Derived Mononuclear Cells for Ischemic Cardiomyopathy
This is an evaluative, monocentric study in patients with chronic ischemic heart disease and left bundle branch block who received an ICD-CRT.
- Trial name
- Alster-Star (NCT01144221)
- Testing
- Intramyocardial Cell therapy
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Kai Jaquet, PhD, DSc
Anemia, Iron Deficiency, Anemia of Chronic Disease
Hemoglobin Optimization to Prevent Transfusion and Adverse Events in Perioperative Patients With Iron Restricted Anemia
The HOPE-Hb trial is a phase II study to determine the feasibility and impact of a combination treatment (intravenous iron plus erythropoietin) versus intravenous iron treatment alone on preoperative hemoglobin concentration…
- Conditions
- Anemia, Iron Deficiency, Anemia of Chronic Disease, Hip Arthropathy, Knee Arthropathy
- Trial name
- HOPE-Hb (NCT03528564)
- Testing
- Iron sucrose, Epoetin Alfa
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Unity Health Toronto
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Wound Heal
Postoperative Wounds With Delayed Healing Risk of Clinical Trial Registration
this study aims to optimize the components of TIME CDST based on clinical practice and apply the optimized elements to the management of wounds with delayed healing risk after hip arthroplasty to identify and design the key steps…
- Trial name
- NCT06272097
- Testing
- Intervention program based on TIME-CDST tool led by wound specialist nurses, A routine wound care program
- Volunteers
- 492 people
- Sponsor
- Danni Feng
Sequence Optimization, Protocol Optimization
Optimization of Cardiac-MR Protocols
The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR…
- Conditions
- Sequence Optimization, Protocol Optimization, Normal Values, Feasibility
- Trial name
- NCT00557869
- Where
- Austria
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Atherosclerotic Disease
Spectral CT Protocol Optimization for Atherosclerotic Plaque CharacterizatION
The SCORPION study (Spectral CT Protocol Optimization for Atherosclerotic Plaque Characterization) is a retrospective and prospective observational research project aimed at improving the diagnostic accuracy of dual-energy CT…
- Trial name
- SCORPION (NCT06886958)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS SYNLAB SDN
Postoperative Complications
Evaluation of Goal-Directed Intraoperative Hemodynamic Optimization Protocol
As part of a quality assurance program, the Department of Anesthesiology implemented a Goal-Directed Fluid Management training course for all physicians and nurses to provide goal-directed fluid management.
- Trial name
- NCT02057653
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, Irvine
Medication Adherence
Reducing African-American CVD Disparities Intervention Optimization (RADIO) Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among Black and African American individuals on…
- Trial name
- RADIO (NCT05954000)
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Prediabetes, Exercise
Optimization of Exercise Protocol for Prediabetic Population in Postprandial State
The core purpose of the project is to find out optimal exercise protocol for control of hyperglycemia and insulin resistance in prediabetic.
- Conditions
- Prediabetes, Exercise, Blood Glucose Profile, Lipid Profile
- Trial name
- NCT06656377
- Testing
- exercise intervention
- Where
- Pakistan
- Volunteers
- 25 people
- Sponsor
- Khyber Medical University Peshawar
Measuring Red Blood Cell Survival After Transfusion
Optimization of Biotinylation Protocol for Studies of Red Blood Cell Survival and Function After Transfusion
The goal of this clinical trial is to compare two methods of labeling red blood cells with biotin. The main question to answer is whether red blood cells labeled 48 hours before transfusion survive as long as red blood cells…
- Trial name
- NCT06788080
- Testing
- BioRBC
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Cetrotide Treatment Optimization
Rationale: In daily practice fertility treatment is increasingly patient focused and innovative medication and standardized treatment guidelines are being developed to improve patient convenience.
- Trial name
- NCT00866034
- Testing
- Cetrotide (Ovarian stimulation)
- Where
- Netherlands
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Sepsis, Device Performance
PIVO Use for Blood Cultures in the Emergency Department
The investigators will implement a protocol for use of the PIVO device for blood culture collection in the emergency department.
- Conditions
- Sepsis, Device Performance, Emergency Medicine
- Trial name
- PIVO-ED (NCT07348289)
- Testing
- PIVO device, a needle-free blood draw device
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Intermountain Health Care, Inc.
Cardiac Failure
The Development and Optimization of a Cardiac Magnetic Resonance Imaging Protocol in a 3 Tesla Scanner
In recent years, evaluating cardiac function with magnetic resonance imaging (MRI) has drawn widespread interest. However, cardiac MRI is prone to severe motion artifacts from cardiac contraction, frequently requiring complex…
- Trial name
- NCT07889076
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wang . Jiun-Jie