Clinical trials: Protocol Optimization
Dosimetry
Dosimetry Using a CZT-camera Following LUTATHERA® Therapy
The aim of this study is to assess the consistency between a dosimetry protocol using a large field of view CZT-camera and the dosimetry protocol used for recordings acquired with a conventional camera.
- Trial name
- EVADOVE177Lu (NCT04467567)
- Testing
- Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Optimization of Second Line Treatment Protocol for H Pylori Eradication
Sequential Therapy Versus Quadruple Therapy as Second Line Treatment After Failure of the Standard Triple Therapy for H Pylori Infection
The aim of this study is to evaluate the efficacy of sequential therapy, i.e. 5 days of PPI + amoxicillin followed by 5 days of PPI + two antimicrobial drugs( clarithromycin and tinidazole ) versus quadruple drug regimen( i.e.-14…
- Trial name
- NCT01481844
- Testing
- Lansoprazole , Tab Amoxycillin , Tab Clarithromycin ,Tab Tinidazole, Lansoprazole, Bismuth Subsalicylate, Metronidazole, Tetracycline
- Where
- Israel
- Volunteers
- 101 people
- Sponsor
- Soroka University Medical Center
Ovarian Cancer
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
Ovarian cancer is a lethal disease with an estimated 310,000 new cases and 200,000 deaths experienced worldwide in 2020. The purpose of this study is to assess the adverse events and change in disease activity of mirvetuximab…
- Trial name
- FLORENZA (NCT07059845)
- Testing
- Mirvetuximab Soravtansine, Bevacizumab, Carboplatin
- Where
- 86 sites in United States, Australia and 6 more
- Volunteers
- 400 people
- Sponsor
- AbbVie
Perioperative Optimization
Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after…
- Trial name
- NCT04606264
- Testing
- Neuraxial Analgesia, Regional Block 1: Paravertebral, Perphenazine
- Where
- 3 sites in United States
- Volunteers
- 3,395 people
- Sponsor
- Jennifer Holder-Murray
Cardiac Failure
The Development and Optimization of a Cardiac Magnetic Resonance Imaging Protocol in a 3 Tesla Scanner
In recent years, evaluating cardiac function with magnetic resonance imaging (MRI) has drawn widespread interest. However, cardiac MRI is prone to severe motion artifacts from cardiac contraction, frequently requiring complex…
- Trial name
- NCT07889076
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wang . Jiun-Jie
Measuring Red Blood Cell Survival After Transfusion
Optimization of Biotinylation Protocol for Studies of Red Blood Cell Survival and Function After Transfusion
The goal of this clinical trial is to compare two methods of labeling red blood cells with biotin. The main question to answer is whether red blood cells labeled 48 hours before transfusion survive as long as red blood cells…
- Trial name
- NCT06788080
- Testing
- BioRBC
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vitalant Research Institute
Cerebral Palsy (CP)
Optimized AFO Care For Children With Cerebral Palsy.
Ankle-foot orthoses (AFOs) are widely prescribed in children with cerebral palsy (CP) to improve their gait, enhance mobility and prevent secondary complications during growth.
- Trial name
- OPTI-CARE (NCT07811336)
- Testing
- Optimized AFO care
- Where
- Netherlands
- Volunteers
- 86 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Extracellular Vesicles
Optimization of the Isolation Protocol for Extracellular Vesicles (EVs) From Human Follicular Fluid
Background: Extracellular vesicles (EVs) are membrane-bound vesicles found in all biological fluids, containing various regulatory molecules, including microRNAs (miRNAs).
- Trial name
- NCT06952751
- Testing
- Differential ultracentrifugation, OptiPrep™ density gradient ultracentrifugation, Size-exclusion chromatography
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Hemodynamic Instability
Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach
This study compares the actual standard of care with a new protocol to guide hemodynamic optimization during major abdominal surgery, which is more tailored on patient real needs.
- Trial name
- HEART-CORE (NCT03113435)
- Testing
- Oxygen consumption optimization
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Heart Failure with Reduced Ejection Fraction, Chronic Heart Failure
Efficacy of a Streamlined Heart Failure Optimization Protocol
The SHORT trial compares the current standard optimization protocol to a shortened protocol in a randomized control trial.
- Trial name
- SHORT (NCT05021419)
- Testing
- Streamlined protocol, Standard Protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
Longevity, Women's Health
A Real-World Evidence Study Evaluating the Effects of the Human Optimization Project Protocol on Methylation Biomarkers and Health-Related Quality of Life in Women
This study looks at whether a daily dietary supplement called HOP Box can improve markers of biological aging and overall health in women.
- Trial name
- NCT07548645
- Testing
- Human Optimization Project
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Human Optimization Project
Polypharmacy
Pharmacological Optimization by a Specialized Outpatient Consultation Team
Background Polypharmacy is a common condition among older adults and is a major issue of concern for its association with adverse drug reactions and adverse health outcomes, including falls, functional and cognitive impairment…
- Trial name
- NCT05408598
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Fundacion Miguel Servet
Prediabetes, Exercise
Optimization of Exercise Protocol for Prediabetic Population in Postprandial State
The core purpose of the project is to find out optimal exercise protocol for control of hyperglycemia and insulin resistance in prediabetic.
- Conditions
- Prediabetes, Exercise, Blood Glucose Profile, Lipid Profile
- Trial name
- NCT06656377
- Testing
- exercise intervention
- Where
- Pakistan
- Volunteers
- 25 people
- Sponsor
- Khyber Medical University Peshawar
Cerebral Palsy
Isokinetic Strength Training in Children With Hemiparetic Cerebral Palsy
This study endeavored to assess the effect of an isokinetic strength training (IsoK-ST) program on weight-bearing symmetry, gait-symmetry, and dynamic balance in children with hemiparetic cerebral palsy (HCP).
- Trial name
- NCT04907448
- Testing
- Physical Therapy
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Cairo University
Medication Adherence
Reducing African-American CVD Disparities Intervention Optimization (RADIO) Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among Black and African American individuals on…
- Trial name
- RADIO (NCT05954000)
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Uniportal Video-assisted Thoracic Surgery
Optimization of Perioperative Analgesia Protocol for Uniportal Video-assisted Thoracoscopic Surgery
Trial design Despite video-assisted thoracic technology and procedure specific postoperative pain management (PROSPECT) have been promoted through recent years, thoracic surgery is still considered to be one of the most painful…
- Trial name
- NCT06016777
- Testing
- Ultrasound-guided paraspinal block and patient-controlled intravenous analgesia pump, Ultrasound-guided erector spinal block and patient-controlled intravenous analgesia pump, Patient-controlled intravenous analgesia pump
- Where
- China
- Volunteers
- 102 people
- Sponsor
- China-Japan Friendship Hospital
Appendicitis, Other and Unspecified Acute Appendicitis
The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis
This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis.
- Conditions
- Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Diseases
- Trial name
- OPTICAP (NCT02533869)
- Testing
- Low-dose CT, Laparoscopic appendectomy
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Neonatal Congenital Heart Disease
Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High Altitude
This is a prospective observational screening study. First, researchers will optimize a two-indicator screening protocol for neonatal congenital heart disease (NCHD) adapted to high-altitude regions and evaluate its screening…
- Trial name
- NCT07901998
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Sepsis, Device Performance
PIVO Use for Blood Cultures in the Emergency Department
The investigators will implement a protocol for use of the PIVO device for blood culture collection in the emergency department.
- Conditions
- Sepsis, Device Performance, Emergency Medicine
- Trial name
- PIVO-ED (NCT07348289)
- Testing
- PIVO device, a needle-free blood draw device
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Intermountain Health Care, Inc.
Healthy
Acquisition and Analysis Protocol Optimization of Neurophysiological Data Neurorehabilitation Settings
The study aims to optimize and validate protocols for acquiring neurophysiological data, specifically resting state functional connectivity, using advanced research techniques (hdEEG and MEG) and a user-friendly device (MUSE).
- Trial name
- MEEGOPTI (NCT06297057)
- Testing
- Neurophysiological Recordings
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy