Clinical trials: Pruritis
Atopic Dermatitis
The Purpose of This Study is to Evaluate the Effects of Ruxolitinib Cream on Adults With Atopic Dermatitis Experiencing Sleep Disturbance.
The purpose of the study is to evaluate the effect of ruxolitinib cream on sleep disturbances with participants with Atopic Dermatitis.
- Trial name
- MORPHEUS (NCT05696392)
- Testing
- ruxolitinib cream
- Where
- 30 sites in United States
- Volunteers
- 47 people
- Sponsor
- Incyte Corporation
Angioedema
AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study
This is a multicenter study recruiting patients with angioedema induced by ACEI. Open-label treatment with subcutaneous Icatibant compared to a historic group of 47 patients with ACE inhibitor induced angioedema which the…
- Trial name
- NCT01154361
- Testing
- Icatibant (subcutaneous) and plazebo (intravenous), Cortisone + Clemastin (intravenous) and plazebo (subcutaneous)
- Where
- Germany
- Sponsor
- Technical University of Munich
Itch, Thermal Stimulation
A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch.
- Conditions
- Itch, Thermal Stimulation, Histamine, Cowhage
- Trial name
- NCT03576053
- Testing
- Lidocaine, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tinea Pedis
Non-inferiority Phase III Trial Comparing Dapaconazole Cream 2% With Ketoconazole Cream 2% in Patients With Tinea Pedis
This is a non-inferiority, Phase III, open-label, randomized, parallel trial to evaluate the new intervention Dapaconazole cream 2% versus Ketoconazole cream 2% in patients with Tinea pedis.
- Trial name
- NCT02606383
- Testing
- Dapaconazole, Ketoconazole
- Where
- Brazil
- Sponsor
- Biolab Sanus Farmaceutica
Tinea Pedis
Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis
Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis
- Trial name
- NCT03824912
- Testing
- Ketoconazole Cream 2%, Ketoconazole Cream 2% (G&W Laboratories Inc.)
- Where
- 9 sites in United States, Belize and 1 more
- Volunteers
- 831 people
- Sponsor
- Encube Ethicals Pvt. Ltd.
Tinea Pedis
Topical Antifungal Treatment for Tinea Pedis
The purpose of this study is to determine if a topical antifungal cream is safe and effective for the treatment of tinea pedis.
- Trial name
- NCT01396811
- Testing
- 33525
- Where
- 11 sites in United States, Belize
- Volunteers
- 322 people
- Sponsor
- Medicis Global Service Corporation
Chronic Kidney Disease-Associated Pruritus in Hemodialysis
Clinical Study on the Efficacy and Safety of Nalfurafine Hydrochloride Orally Disintegrating Tablets in Treating Pruritus in Patients Undergoing Maintenance Hemodialysis
This is a randomized, open-label, multi-center clinical study aimed at evaluating the efficacy and safety of 12 weeks of nalfurafine hydrochloride administration in the treatment of pruritus in patients undergoing maintenance…
- Trial name
- NCT07650851
- Testing
- Nalfurafine Hydrochloride, Basic treatment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Bladder Cancer
The Impact of Intrathecal Morphine Versus Continuous Epidural Analgesia on Return of Bowel Function in Patients Undergoing Laparoscopic Ileal Conduit
This study aims to compare the effects of intrathecal morphine (ITM) and continuous epidural analgesia (CEA) on bowel function recovery after Bricker surgery.This study was a prospective, randomized controlled trial that included…
- Trial name
- NCT06688643
- Testing
- ITM group, EA group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xiaguang Duan
Liver Disease, Cholestasis
Gabapentin to Treat Itch in Patients With Liver Disease
In this study, the effect of the medication gabapentin to treat itching secondary to liver disease is being studied. There are some funds to cover travel expenses for patients who are not from New York (NY).
- Conditions
- Liver Disease, Cholestasis, Cirrhosis, Pruritus
- Trial name
- NCT00058890
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pruritus, Skin Disorder
Defining N-Acetyl Cysteine as a Treatment for Inhibiting Prurogenic Stimuli
The objective of this double-blinded placebo-controlled cross-over study is to define the role of the over the counter agent, N-acetyl cysteine (NAC), in mitigating the development of pruritus (skin itching).
- Trial name
- NCT05287724
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wright State University
Dermatophytoses
Novel Electrolyzed Water Spray Treatment Mild Dermatophytosis
The purpose of this study is to test whether spraying the skin of patients of patients by use of the novel electrolyzed water spray will produce improvement in the condition of mild dermatophytosis.
- Trial name
- NCT05770245
- Testing
- The novel electrolyzed water spray
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Dove Medical Press Ltd
Pruritus
Does Indoxyl Sulfate Have a Role in Uremic Pruritus?
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe…
- Trial name
- NCT05634083
- Testing
- Uremic pateints with itching
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Benha University
Uremic Pruritus, Pruritus
Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
The primary objectives of the study to evaluate the effects of two doses of nalbuphine HCl ER tablets on the change from baseline in the worst itch Numerical Rating Scale (NRS) in hemodialysis patients with moderate to severe…
- Trial name
- NCT02143648
- Testing
- nalbuphine HCl ER tablets 60 mg BID, nalbuphine HCl ER tablets 120mg BID
- Where
- 47 sites in United States, Poland and 1 more
- Volunteers
- 373 people
- Sponsor
- Trevi Therapeutics
Atopic Dermatitis
A Study to Assess the Safety and Efficacy of ZPL389 With TCS/TCI in Atopic Dermatitis Patients
This extension study (CZPL389A2203E1) was designed as a 2-year (100 weeks) extension to the core study (CZPL389A2203/ NCT03517566) which is disclosed separately.
- Trial name
- ZESTExt (NCT03948334)
- Testing
- ZPL389 30mg, ZPL389 50mg, TCS and/or TCI
- Where
- 48 sites in United States, Belgium and 11 more
- Volunteers
- 123 people
- Sponsor
- Novartis Pharmaceuticals
Tinea Pedis, Tinea Cruris
Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris
The objective of this study is to evaluate the pharmacokinetics of luliconazole cream 1%, as measured by circulating plasma levels of luliconazole, when maximal quantity of luliconazole cream 1% is applied to participants of 12…
- Trial name
- NCT02767271
- Testing
- Luliconazole Cream 1%
- Where
- 2 sites in Dominican Republic, Honduras
- Volunteers
- 30 people
- Sponsor
- Bausch Health Americas, Inc.
Indolent Systemic Mastocytosis
Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis
The objective of this study is to compare the safety and efficacy of masitinib (AB1010) to placebo in patients with mastocytosis with handicap.
- Trial name
- AB06006 (NCT00814073)
- Testing
- Masitinib, Best Supportive Care
- Where
- 24 sites in United States, France
- Volunteers
- 135 people
- Sponsor
- AB Science
Itch
Survey on Itch in Outpatients of a University Clinic
This study is to investigate the pruriception (i.e. the perception of the character and intensity of itch), the impact of itch on quality of life, the response to itch and the subjective efficacy and preferences of the different…
- Trial name
- NCT03901443
- Testing
- Survey on itch
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Basel, Switzerland
Eczema
A Test to Determine the Usefulness and Safety of a Cream Used on Babies With Dry Itchy Skin
This study is for infants with mild to moderate dry and itchy skin. This study will involve going to the doctor for 6 visits over 2 weeks.
- Trial name
- NCT02120833
- Testing
- EpiCeram® Skin Barrier Emulsion, Colloidal Oatmeal Cream
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Psoriasis of Scalp, Psoriasis Vulgaris
Apremilast Treatment for Pruritus and Quality of Life in Scalp Psoriasis
A phase 4 multicenter, randomized, placebo-controlled Study evaluating the Effect of Apremilast on Pruritus and Quality of Life of Patients with moderate-to-severe Scalp Psoriasis
- Trial name
- APRESCALP (NCT03553433)
- Testing
- Apremilast 30mg
- Where
- 4 sites in Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Postoperative Nausea and Vomiting
Risk Factors for Postoperative Nausea, Vomiting and Pruritus
In this study we would like to identify demographic and individual risk factors that place parturients at a higher risk for postoperative nausea and vomiting (PONV) and itching following administered neuraxial morphine for…
- Trial name
- NCT03178058
- Testing
- Questionaire
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center