Clinical trials: Pruritis
End Stage Renal Failure
Effect of Turmeric on Pruritus in Hemodialysis Patients
The purpose of this study is to see whether turmeric can be effective in treatment of pruritus in hemodialysis patients.
- Trial name
- NCT01037595
- Testing
- turmeric
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Itch, Pain
Investigation of Corticospinal Excitability Aspects of Itch and Pain
The experiment consists of three experimental sessions conducted over a period of two weeks. In the first experimental session, we apply in your hand: either an injection of salt water (7% NaCl) or we apply small needles from the…
- Trial name
- NCT06470737
- Testing
- Hypertonic Saline, Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Dermatitis, Atopic
Investigation of Topical SB705498 on Healthy Volunteers
A two part, randomized, double-blind, placebo controlled study to investigate the effects of topical doses of SB705498 in healthy volunteers.
- Trial name
- NCT01673529
- Testing
- SB705498
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Uremic Pruritus
Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus
This is a single-center clinical research study with the purpose to evaluate the safety, tolerability, and pharmacokinetics (PK) of nalbuphine HCl ER (extended release) tablets in end-stage renal disease (ESRD) patients receiving…
- Trial name
- NCT02373215
- Testing
- Nalbuphine HCL ER
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Trevi Therapeutics
Uremic Pruritus
Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis
This study is being conducted to investigate the efficacy of MT-9938 compared with placebo after 2 weeks, to continue to evaluate efficacy for an additional 6 weeks, and to explore the effect of a reduction in itching intensity…
- Trial name
- NCT01660243
- Testing
- Nalfurafine hydrochloride(MT-9938) 2.5μg, Nalfurafine hydrochloride(MT-9938) 5μg, Nalfurafine hydrochloride(MT-9938) 10μg
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Toray Industries, Inc
End-Stage Kidney Disease (ESKD), Hemodialysis
Cardiovascular and Bone Mineral Markers in Dialysis Patients and Healthy Controls
This observational study will compare cardiovascular status, bone mineral metabolism, systemic inflammation, body composition, functional status, quality of life, pruritus, and pain among patients receiving different renal…
- Conditions
- End-Stage Kidney Disease (ESKD), Hemodialysis, Peritoneal Dialysis (PD)
- Trial name
- NCT07686978
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gazi University
Pruritus
Swiss Itch Registry
This project is to develop a national registry for CP patients. Patients admitted to this registry will be examined and documented with PROs, physician-based assessments, blood tests, 3D photodocumentation and, if indicated, by…
- Trial name
- SWITCHR (NCT06120907)
- Testing
- Data collection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Itching
Post Burn Pruritus Study in Patients Undergoing Wound Healing
The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as well or better than the usual drug used, diphenhydramine (Benadryl).
- Trial name
- NCT00137202
- Testing
- Ondansetron (Zofran), Diphenhydramine (Benadryl)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- United States Army Institute of Surgical Research
Tinea Pedis
Cumulative Irritation Test
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT00781664
- Testing
- AN2718, Sodium Lauryl Sulfate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pfizer
Eczema
Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin
The purpose of this 3 week study is to test the effectiveness of an over-the-counter (OTC) skin balm in infants and toddlers with mild to moderate dry, itchy skin.
- Trial name
- NCT02404493
- Testing
- EpiCeram Skin Barrier Emulsion, 1% Colloidal Oatmeal Balm
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Cholinergic Urticaria
Cholinergic Urticaria - Efficacy of Dupilumab
The purpose of this study is to assess the efficacy in reducing disease activity and safety of Dupilumab in adult patients with cholinergic urticarial (CholU) who are symptomatic despite H1-antihistamine treatment (licensed dose).
- Trial name
- CHED (NCT03749148)
- Testing
- Dupilumab
- Where
- 8 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Charite University, Berlin, Germany
Psoriasis, Acne
Psychiatric Problems in Chronic Skin Diseases
The purpose of this study is to investigate the prevalence of depression, anxiety, and sleep problems in patients with chronic skin diseases in dermatology clinics at the University of Wisconsin Hospital and Clinics.
- Conditions
- Psoriasis, Acne, Vitiligo, Atopic Dermatitis
- Trial name
- NCT00167752
- Sponsor
- University of Wisconsin, Madison
Consent Form, Lung Cancer
Education Intervention in Patients with Rash Due to Epidermal Growth Factor Receptor (EGFR) Treatment.
The main adverse reaction of EGFR seen in patients is rash. EGFR treated patients have a 24-95% incidence of rash depending on the type of treatment they receive.
- Conditions
- Consent Form, Lung Cancer, Colon Cancer, Pancreas Cancer
- Trial name
- NCT03992664
- Testing
- Educational training program
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Cyprus University of Technology
Chronic Pruritus
Causes of Chronic Pruritus
The aim of this study is to include all patients followed between 2008 and 2018 in order to analyze the etiologie of the chronic pruritus
- Trial name
- PRURISINE (NCT04949893)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Itch
Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch
With this experiment, the experimenter wish to create a new model of itch based on the substance BAM8-22 (Bovine Adrenal Medulla), which is found naturally in the human body and which has proved to evoke itch.
- Trial name
- NCT04197440
- Testing
- BAM8-22 2mg/ml, BAM8-22 1mg/ml, BAM8-22 0.5 mg/ml
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus
Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the…
- Trial name
- NCT04399148
- Testing
- Desloratadine 5 mg, Aprepitant 125 mg, Ketotifen 1 MG
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cutaneous Nerves CNS Itch
Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function
The purpose of this study is to assess the safety and efficacy of oral clonidine in subjects with symptomatic atopic dermatitis and to assess the safety and efficacy of oral naltrexone in subjects with symptomatic atopic…
- Trial name
- NCT02268448
- Testing
- Clonidine, Naltrexone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Moderate to Severe Plaque Psoriasis
Analysis of the Pathogenesis of Itch in Response to Apremilast Therapy in Psoriasis Patients
This study aims to identify and describe the presence of itch active molecules in psoriasis and response to treatment with apremilast.
- Trial name
- Itch (NCT03146247)
- Testing
- Apremilast;Apremilast;Apremilast 10 MG; 20 MG; 30 MG Oral Tablet
- Where
- Germany
- Sponsor
- Diamant Thaci
Itching
Effect of Slow Injection of Fentanyl on the Incidence of Spinal Anesthesia Induced Itching in Cesarean Section
Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself.
- Trial name
- NCT02951806
- Testing
- (R) Rapid spinal fentanyl injection, (S) Slow spinal fentanyl injection
- Volunteers
- 215 people
- Sponsor
- Dr. Soliman Fakeeh Hospital
Mediciine, Systemic Sclerosis (SSc)
Topical Cannabidiol Lotion for Pruritus Relief in Scleroderma
Itching is one of the common symptoms found in patients with scleroderma, with a prevalence of about 42-62%, and it often occurs in the early stages of the disease.
- Conditions
- Mediciine, Systemic Sclerosis (SSc), Intervention Study
- Trial name
- cannabidiol (NCT07245238)
- Testing
- 10% urea lotion plus 1% cannabidiol, Control
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Khon Kaen University