Clinical trials: Pruritis
Pruritus
A Trial of SHR0410 Injection in Hemodialysis Participants.
This is a multi-site study to evaluate the safety and pharmacokinetics of repeated doses of IV SHR0410 in participants who are undergoing hemodialysis.
- Trial name
- NCT03857568
- Testing
- SHR0410
- Where
- Australia
- Volunteers
- 8 people
- Sponsor
- Atridia Pty Ltd.
Allergic Rhinoconjunctivitis, Chronic Urticaria
Pharmacokinetic Study of Bilastine in Children From 2 to < 12 Years of Age With Either Allergic Rhinoconjunctivitis (AR) or Chronic Urticaria (CU)
The conduct of this clinical trial is aimed at determining the most suitable dose regimen for children in different age groups, and secondarily to assess the safety and tolerability of bilastine in this paediatric population…
- Trial name
- NCT01081574
- Testing
- Bilastine
- Where
- 7 sites in Australia, Germany and 1 more
- Volunteers
- 36 people
- Sponsor
- Faes Farma, S.A.
Pain, Burning, Capsaicin
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
In This experiment, the investigators would like to test following hypotheses: the pain stimulation applied at the same time of a pruriceptive stimulus will decrease the itch perception.
- Trial name
- NCT06185582
- Testing
- Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pruritus, Chronic Urticaria
Safety Study of Levocetirizine and Fexofenadine
This Study is to comparison of Efficacy and Consistency of Action of Levocetirizine 5 mg once daily with Fexofenadine 60 mg twice daily in the histamine induced wheal, flare and itch Response.
- Conditions
- Pruritus, Chronic Urticaria, Allergic Rhinitis
- Trial name
- LAWAF (NCT01586091)
- Testing
- Levocetirizine Oral Tablet, Fexofenadine 60 Mg Oral Tablet
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Histamine, Cowhage
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli.
- Trial name
- NCT06328543
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Primary Sclerosing Cholangitis
Probiotics in Patients With Primary Sclerosing Cholangitis
PSC is a progressive liver disease without effective medical treatment. There is often co-existent ulcerative colitis. Probiotics (bacterial food supplements) have been shown to benefit patients with ulcerative colitis.
- Trial name
- NCT00161148
- Testing
- Probiotics
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Itch
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms.
- Trial name
- IL-13 (NCT06503510)
- Testing
- Histamine, Cowhage, bovine adrenal medulla (BAM8-22)
- Where
- 3 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Chronic Pruritus Due to Plaque Psoriasis
An Exploratory Study to Assess the Efficacy of the Avène Hydrotherapy
To assess the benefit of the Avène hydrotherapy in subjects with pruritic plaque psoriasis
- Trial name
- PAP (NCT03023254)
- Testing
- Hydrotherapy
- Where
- 29 sites in France, Spain
- Volunteers
- 44 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Atopic Dermatitis
Phase 2b Study of EVO756 in Adults With Atopic Dermatitis
This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe atopic dermatitis.
- Trial name
- NCT07150845
- Testing
- EVO756
- Where
- 29 sites in United States, New Zealand
- Volunteers
- 121 people
- Sponsor
- Evommune, Inc.
Ankle Injuries, Instability; Ankle (Ligaments) (Old Injury)
A Morphological Study in Volleyball Athletes With Cronic Ankle Instability
The former purpose of this study to investigate the effect of transverse abdominis, lumbar multifidus, vastus lateralis, lateral gastrocnemius, anterior talofibular ligament of morphology on explosive power and balance…
- Conditions
- Ankle Injuries, Instability; Ankle (Ligaments) (Old Injury), Radiological Devices Associated With Adverse Incidents, Diagnostic and Monitoring Devices, Athlete Foot
- Trial name
- NCT05746663
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Itching
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity ( IL-13 )
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms.
- Trial name
- NCT07017231
- Testing
- histamine dihydrochloride, Cowhage
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Aalborg University
Atopic Dermatitis
Tolerance and Efficacy Open-label Study With RV4421B, in Various Populations With Atopic Dermatitis for 12 Weeks
Pierre Fabre Laboratories have developed a cream with medical device status, RV4421B-EV0407 indicated for the treatment of eczemas, including atopic eczema, contact eczema and chronic hand eczema.
- Trial name
- NCT07014007
- Testing
- RV4421B- EV0407
- Where
- Mauritius
- Volunteers
- 105 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Tinea Pedis
Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot
The purpose of this study is to determine the fungicidal efficacy of nitric oxide releasing solution footbath and it's effect on the clinical signs and symptoms associated with Tinea Pedis
- Trial name
- NCT02871011
- Testing
- Nitric Oxide, Water
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nitric Solutions Inc.
Notalgia Paresthetica
Neural Therapy in Notalgia Paresthetica
Patients diagnosed with Notalgia paresthetica and who received neural therapy within the last year were retrospectively screened.
- Trial name
- NCT06508073
- Testing
- Neural Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Alagille Syndrome
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome
The study is a randomized, double-blind, placebo-controlled study in children with Alagille Syndrome (ALGS). The study will investigate the effects of LUM001, compared to placebo, on pruritus, serum bile acids, liver enzymes, and…
- Trial name
- ITCH (NCT02057692)
- Testing
- LUM001
- Where
- 13 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Chronic Spontaneous Urticaria
A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1 Antihistamines
The purpose of this study was to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) in adult participants suffering from chronic spontaneous urticaria (CSU) inadequately controlled by H1-antihistamines in…
- Trial name
- REMIX-1 (NCT05030311)
- Testing
- LOU064 25 mg (b.i.d), LOU064 25 mg (b.i.d) as a tablet.
- Where
- 112 sites in United States, Argentina and 17 more
- Volunteers
- 470 people
- Sponsor
- Novartis Pharmaceuticals
Pruritus, Chronic Pruritus
Establishment of a Patient Library in Patients With Pruritus Sine Materia
Very little is currently known about the pathophysiology of pruritus sine materia according to the etiology. The creation of this cohort should make it possible to improve our clinical and biological knowledge according to the…
- Conditions
- Pruritus, Chronic Pruritus, Itch
- Trial name
- PRURITHEQUE (NCT05678309)
- Testing
- Blood samples, skin swab sample, skin biopsy sample
- Where
- France
- Volunteers
- 175 people
- Sponsor
- University Hospital, Brest
Pruritus, Uremic Pruritus
Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus
The primary purpose of this study is to: Evaluate the safety and pharmacokinetic profile of repeated doses IV CR845 over one week in patients who are undergoing hemodialysis.
- Trial name
- NCT02229929
- Testing
- Part A: CR845 0.5 mcg/kg, Part A: CR845 1.0 mcg/kg, Part A: CR845 2.5 mcg/kg
- Where
- 20 sites in United States
- Volunteers
- 89 people
- Sponsor
- Cara Therapeutics, Inc.
Tinea Pedis
An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot
The purpose of this study is to determine if a new formulation of ketoconazole 2% cream is as effective as a current formulation of ketoconazole 2% cream (Nizoral) compared with placebo in treating patients with Tinea pedis, a…
- Trial name
- NCT01110330
- Testing
- Ketoconazole 2% cream (formulation F012) (Nizoral), Ketoconazole 2% cream (formulation F126)
- Where
- 11 sites in Poland, United Kingdom
- Volunteers
- 583 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cutaneous T-Cell Lymphoma
Recalcitrant Pruritus in Cutaneous T-Cell Lymphoma
The purpose of this study is to define the mechanisms that underlie the refractory pruritus (itch) in Cutaneous T-Cell Lymphoma (CTCL).
- Trial name
- CTCL (NCT00863395)
- Testing
- skin biopsy
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Minnesota