Clinical trials: Pruritis
Itching Symptoms, CKD 5D, Hemodialysis
Difelikefalin for Itching in Hemodialysis Patients With Chronic Kidney Disease
A randomized, placebo-controlled, double-blind trial will be conducted in the Department of Nephrology at Chittagong Medical College Hospital, Chattogram, Bangladesh, over a period of one and a half years.
- Trial name
- NCT07526324
- Testing
- Difelikefalin Injection, Normal Saline (0.9% NaCl)
- Volunteers
- 106 people
- Sponsor
- Chittagong Medical College
Burn Injury, Chronic Pain
Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain and itching associated with burn injury. This study is part of the Boston-Harvard Burn Model System.
- Conditions
- Burn Injury, Chronic Pain, Pruritus, Itching
- Trial name
- NCT01795079
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Spaulding Rehabilitation Hospital
Skin Toxicity in Patients on Checkpoint Inhibitors
"Evaluation of a Non-Pharmacological Skin Care Intervention for the Prevention and Treatment of Skin Toxicities Caused by Immunotherapy in Cancer Patients"
Due to recent approvals, a significant number of adult cancer patients are undergoing treatment with checkpoint inhibitor antibodies.
- Trial name
- NCT07337486
- Testing
- Shea Butter and Niacinamide, Argan Oil and Coconut Butter
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Urticaria
Glucocorticoids With Antihistamines Versus Antihistamines in Acute Urticaria in Emergency
Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment.
- Trial name
- CAHISU (NCT02565680)
- Testing
- prednisone
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Tinea Pedis
A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Moderate - Severe Interdigital Tinea Pedis
The purpose of this study is to determine if the novel oral agent VT-1161 is safe and effective in treating patients with moderate - severe tinea pedis (also referred to as athletes foot).
- Trial name
- NCT01891305
- Testing
- VT-1161
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Viamet
Diabetic Pruritus, Efficacy of Pregabalin in Controlling Diabetic Pruritus Severity
Efficacy of Pregabalin for Diabetic Pruritus - A Randomized Controlled Study.
Brief Summary: The goal of this randomized controlled study is to learn if pregabalin combined with emollients can reduce pruritus (itching) in people with Type 2 Diabetes Mellitus.
- Trial name
- PREDICT (NCT06790537)
- Testing
- Pregabalin 75 mg
- Where
- 2 sites in India
- Volunteers
- 46 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Itch
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor
In this experiment the investigators would like to assess if papain induces an itch sensation comparable to the itch sensation induced by cowhage and to confirm that the mechanism of action of papain follows the non-histaminergic…
- Trial name
- NCT04554888
- Testing
- Doxepin Topical, Papain, Histamine
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Intrahepatic Cholestasis of Pregnancy
The Effect of a Single Intravenous Injection of Esketamine During Cesarean Section on Postoperative Pruritus in Patients With Intrahepatic Cholestasis of Pregnancy
To explore the effect of a single intravenous injection of esketamine during cesarean section on postoperative pruritus in patients with intrahepatic cholestasis of pregnancy.
- Trial name
- NCT07560722
- Testing
- Normal Saline (0.9% NaCl), Esketamine 0.3mg/kg
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University General Hospital
Atopic Dermatitis, Atopic Dermatitis (AD)
Roflumilast Cream 0.3% for Moderate to Severe Atopic Dermatitis
This Phase 3 study is designed to evaluate the efficacy and safety of once-daily roflumilast cream 0.3% in children, adolescents, and adults with moderate to severe atopic dermatitis.
- Conditions
- Atopic Dermatitis, Atopic Dermatitis (AD), Atopic Dermatitis (Eczema)
- Trial name
- INTEGUMENT 3 (NCT07916480)
- Testing
- Roflumilast Cream 0.3%, Vehicle Cream
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Arcutis Biotherapeutics, Inc.
Pruritis
A Study of Oral Ergocalciferol to Treat Pruritis in Hemodialysis Patients
Pruritis (itching) is common in many people with chronic renal failure on hemodialysis. There may be many different reasons for the pruritis. Efforts to treat the problem have not been very effective.
- Trial name
- CRN11 (NCT01114672)
- Testing
- 50,000 Units Ergocalciferol
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Winthrop University Hospital
Tinea Pedis
A Study to Evaluate Efficacy and Safety of Three W0027 Regimens in the Treatment of Moccasin Type Tinea Pedis (MTTP)
In this phase Ib, multi-centre, randomized, double-blind, placebo-controlled parallel group study, 120 subjects with moccasin type tinea pedis (MTTP) will be enrolled at approximately 11 centres in the USA, Canada and Australia.
- Trial name
- NCT00509275
- Testing
- W0027
- Where
- 9 sites in United States, Australia
- Volunteers
- 120 people
- Sponsor
- Stiefel, a GSK Company
Pruritus
A Study of HSK21542 in a Peritoneal Dialysis Pruritus Population.
This is a two- stage study. Stage I is a multicenter, open-label trial；Stage II was a multi-center, randomized, double-blind, placebo-controlled trial.
- Trial name
- NCT06290375
- Testing
- HSK21542 tablet
- Volunteers
- 250 people
- Sponsor
- Xizang Haisco Pharmaceutical Co., Ltd
ITCH, Pruritus
Reducing Itch With Hypnosis and Virtual Reality
Chronic itch is a disabling condition with currently limited treatment options. Virtual reality (VR) is a relatively new approach that provides immersion in another environment and has been shown to have a temporary itch…
- Trial name
- VRITCH (NCT06787794)
- Testing
- Virtual Reality-assisted hypnosis
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Universiteit Leiden
Pruritus Caused by Drug
Comparison of Pruritus Incidence After Intrathecal Morphine 0.1 vs 0.2 mg in Cesarean Section
This study compares the incidence of pruritus (itching) requiring treatment between two doses of intrathecal morphine (0.1 mg vs 0.2 mg) when used for spinal anesthesia during cesarean section.
- Trial name
- NCT07054775
- Testing
- Morphine Sulfate
- Where
- 2 sites in Thailand
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Plaque Psoriasis
A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is to evaluate the efficacy, safety, and drug levels of Deucravacitinib (BMS-986165) in adolescent participants with moderate to severe plaque psoriasis
- Trial name
- POETYK-PsO-Ped (NCT06979453)
- Testing
- Deucravacitinib
- Where
- 133 sites in United States, Argentina and 14 more
- Volunteers
- 366 people
- Sponsor
- Bristol-Myers Squibb
Healthy
Topical Tripelennamine 1% Cream Versus Diphenhydramine 1% Cream for the Relief of Histamine-Induced Itching: A Proof Concept Study in Healthy Adults.
The goal of this clinical trial is to determine whether topical tripelennamine 1% cream can relieve histamine-induced itching and whether it is more effective than diphenhydramine 1% cream in healthy adults aged 18 to 50 years.
- Trial name
- NCT07778472
- Testing
- Tripelennamine, Diphenhydramine, Vehicle Control Cream Base
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Palm Beach Atlantic University
Cicatrix, Post-Surgical Complication
Class I Medical Device on Post-surgical Scars
To compare the effect of a class I pullulan based medical device containing Allium cepa \& HA versus a class I medical device silicone gel on new post-surgical wounds
- Conditions
- Cicatrix, Post-Surgical Complication, Scar Itching, Keloid
- Trial name
- NCT05412745
- Testing
- Kaloidon Plus, silicone gel
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- University of Rome Tor Vergata
Chronic Pruritus
Short-term Comparative Clinical Outcomes of Acupuncture and Phototherapy in Chronic Generalized Pruritus
Chronic pruritus is a common and challenging condition with limited effective treatment options. This prospective, randomized comparative study aimed to evaluate the short-term clinical efficacy and safety of acupuncture compared…
- Trial name
- NCT07451353
- Testing
- Sterile disposable acupuncture needles, Narrow Band UVB Phototherapy Unit
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara University
Atopic Dermatitis
Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE)
This is a multicenter, randomized, double-blind, placebo-controlled study to be conducted in the United States in subjects with atopic dermatitis.
- Trial name
- NCT03568331
- Testing
- Tradipitant
- Where
- 70 sites in United States
- Volunteers
- 375 people
- Sponsor
- Vanda Pharmaceuticals
Hemodialysis Complication
REIKI APPLICATION PAIN, FATIGUE AND ITCHING IN HEMODIALYSIS PATIENTS
The research sample consisted of 74 individuals, including the intervention group (n=37) and the control group (n=37), who received hemodialysis treatment at Sivas Cumhuriyet University Application and Research Hospital…
- Trial name
- NCT05531175
- Testing
- Reiki apply
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University