Clinical trials: Pruritis
Tinea Pedis
A Phase 1b Study of ZYG24004 in Participants With Tinea Pedis Caused by Dermatophytes
This is a multicenter, randomized, double-blind, placebo-controlled Phase 1b study in adult participants with tinea pedis caused by dermatophytes.
- Trial name
- NCT07668999
- Testing
- ZYG24004 1% topical film-forming formulation, ZYG24004 3% topical film-forming formulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Sinomune Pharmaceutical Co., Ltd
Itch
Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch
With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22
- Trial name
- NCT05249387
- Testing
- A-967079 and BAM8-22 application, A-967079 and BAM8-22 application after 5 minutes., A-967079 application.
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tinea Pedis
Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra® & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis
The primary objective of this study is to determine the comparability of the safety and efficacy of a generic Butenafine Hydrochloride Cream, 1% (test product) and Lotrimin Ultra® (the reference listed drug) in subjects with…
- Trial name
- NCT01580878
- Testing
- Butenafine Hydrochloride Cream, 1%, Lotrimin Ultra®, Butenafine Vehicle
- Volunteers
- 707 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Cholestasis
Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis
This study is being conducted to evaluate the efficacy, safety and tolerability of GSK2330672 administration for the treatment of pruritus (itch) in participants with primary biliary cholangitis (PBC).
- Trial name
- NCT02966834
- Testing
- GSK2330672
- Where
- 66 sites in United States, Australia and 8 more
- Volunteers
- 147 people
- Sponsor
- GlaxoSmithKline
Chronic Lichenified Atopic Dermatitis
Effects of Electroacupuncture to Relieve Itching Degree in Patients With Chronic Atopic Eczema
Eczema is a common allergic skin disease, accounting for about 15 to 30% of dermatological outpatients. Pruritus as one of the most painful symptoms is often underestimated in terms of the problems that it can cause, which…
- Trial name
- NCT05529836
- Testing
- electroacupunture
- Volunteers
- 126 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Chronic Liver Disease
Colesevelam Versus Placebo in Cholestatic Pruritus
38 patients with pruritus due to chronic cholestatic liver disease will be evaluated in an investigator initiated, multicenter, double-blind, placebo-controlled, 3-week study assessing the effects of colesevelam on pruritus.
- Trial name
- COPE (NCT00756171)
- Testing
- colesevelam
- Where
- 3 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- Foundation for Liver Research
Pruritus, Notalgia Paresthetica
Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica
This is a 2-part, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of twice-daily (BID) oral difelikefalin for moderate-to-severe pruritus in adult subjects with NP.
- Trial name
- NCT05978063
- Testing
- difelikefalin 2.0 mg tablets, difelikefalin 1.0 mg tablets, difelikefalin 0.25 mg tablets
- Where
- 58 sites in United States, Canada and 3 more
- Volunteers
- 214 people
- Sponsor
- Cara Therapeutics, Inc.
Atopic Dermatitis
Social Media Follow-up Nursing for Atopic Dermatitis
This is a randomized controlled study to evaluate the effectiveness of a social media-based (WeChat) networked nursing follow-up intervention compared to conventional nursing care for patients with atopic dermatitis.
- Trial name
- NCT07142993
- Testing
- Social Media-Based Nursing Intervention, Conventional Nursing Care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Hebei Medical University
Ocular Itching, Ocular Allergy
Efficacy and Safety of PRO-118 Ophthalmic Solution in Allergic Conjunctivitis
The purpose of this study is to evaluate the efficacy and safety of four doses of PRO-118 ophthalmic solution ophthalmic solution compared with placebo, for the treatment of seasonal (SAC) and perennial (PAC) allergic…
- Conditions
- Ocular Itching, Ocular Allergy, Seasonal Allergic Conjunctivitis, Perennial Allergic Conjunctivitis
- Trial name
- PRO-118 (NCT01541904)
- Testing
- PRO-118 Ophthalmic Solution 0.015%, PRO-118 Ophthalmic Solution 0.015 %, PRO-118 Ophthalmic Solution 0.020 %
- Where
- 2 sites in Mexico
- Sponsor
- Laboratorios Sophia S.A de C.V.
End Stage Renal Disease, Pruritus
Evaluating the Effect of Senna in Uremic Pruritus
Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in patients with end stage renal disease. It affect up to 90 percent of patients with end stage renal disease.
- Trial name
- NCT02008864
- Testing
- Senna
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Pruritis
Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic
The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.
- Trial name
- NCT06226610
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Akron Children's Hospital
Chronic Spontaneous Urticaria
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
The purpose of this study is to establish the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) inadequately controlled by non-sedating second generation…
- Trial name
- EMBARQ-CSU1 (NCT06445023)
- Testing
- barzolvolimab
- Where
- 235 sites in United States, Argentina and 19 more
- Volunteers
- 963 people
- Sponsor
- Celldex Therapeutics
Vulvovaginal Atrophy, Genital Disorder
Psychometric Validation of the Portuguese DIVAS-Q in Women With Vulvovaginal Atrophic Symptoms
To determine the reliability and validity of the Portuguese version of the DIVA questionnaire in Portuguese women. This validation will support its use both in research and in routine clinical practice in this population.
- Conditions
- Vulvovaginal Atrophy, Genital Disorder, PROMs
- Trial name
- DIVAS-Q (NCT07250490)
- Where
- Portugal
- Volunteers
- 300 people
- Sponsor
- Instituto Politécnico de Leiria
Moderate to Severe Palmoplantar Psoriasis
Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Palmoplantar Psoriasis
Purpose of the study was to demonstrate the efficacy of secukinumab versus placebo on palmoplantar psoriasis and to assess the long term efficacy, safety and tolerability of secukinumab.
- Trial name
- GESTURE (NCT01806597)
- Testing
- secukinumab 150 mg, secukinumab 300 mg
- Where
- 54 sites in United States, Australia and 13 more
- Volunteers
- 205 people
- Sponsor
- Novartis Pharmaceuticals
Pemphigus, Pemphigoid
Wound Dressings for Pemphigus and Pemphigoid
The purpose of this study is to compare the efficacy of four dressings (covers) namely: gauze with petrolatum , cellulose acetate with petrolatum , pure carboxymethylcellulose with silver and nanocrystalline silver to improve the…
- Trial name
- NCT02365675
- Testing
- Cotton gauze with petrolatum, Cellulose acetate with petrolatum, Nanocrystalline silver (Acticoat)
- Where
- 2 sites in Mexico
- Volunteers
- 12 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Pruritus
Topical Acetaminophen for Itch Relief: a Proof of Concept Study in Healthy Subjects
Currently, topical antihistamines and corticosteroids are mainly used for itching relief. However, the over the counter antihistamines are not effective on all itch conditions.
- Trial name
- NCT03997851
- Testing
- Acetaminophen, Carbomer 980
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Miami
Allergic Contact Eczema
Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers
Determine the mean time to itch relief from the start of treatment with topic methylprednisolone aceponate.
- Trial name
- NCT01529320
- Testing
- Adventan® (methylprednisolone aceponate 0,1%)
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fundacion IMIM
Pruritus
Gabapentin for the Treatment of Pruritus Caused by Burn Injuries in Children
Children with healing burns often suffer from pruritus that may continue for many months. Pruritus can be very distressing to the child and can interfere with sleep, activities of daily living, and rehabilitation therapy.
- Trial name
- NCT01092520
- Testing
- Gabapentin
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Prurigo Nodularis, Pruritis
Study to Assess the Efficacy, Safety, and Tolerability of Vixarelimab in Reducing Pruritus in Prurigo Nodularis
Study of the efficacy, safety, tolerability, pharmacokinetics (PK), and immunogenicity of Vixarelimab (KPL-716) in subjects with prurigo nodularis (PN).
- Trial name
- NCT03816891
- Testing
- Vixarelimab
- Where
- 86 sites in United States, Australia and 11 more
- Volunteers
- 240 people
- Sponsor
- Genentech, Inc.
Burns, Pruritus
The Effect of Cold Gel Pack Application on Itching in Burn Patients in the Maturation Stage
Burn is a serious trauma that causes acute damage to the skin and subcutaneous tissues due to the effect of heat, electricity, radiation, physical, and chemical substances.
- Trial name
- NCT06334679
- Testing
- Cold Gel Packet Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University