Clinical trials: Pseudo Obstruction
Chronic Intestinal Pseudo-obstruction
Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial
The objective of the study is to investigate efficacy and safety of rifaximin (L-105) in patients with chronic idiopathic intestinal pseudo-obstruction(CIIPO) or patients with chronic intestinal pseudo-obstruction (CIPO)…
- Trial name
- NCT04118699
- Testing
- Rifaximin oral tablet
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Yokohama City University
Chronic Intestinal Pseudo-Obstruction
Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)
This study was designed to investigate the clinical safety, tolerability and efficacy of prucalopride in improving the symptoms associated with chronic intestinal pseudo-obstruction (CIP) in subjects with CIP.
- Trial name
- NCT00793247
- Testing
- PRU-PLA-PRU-PLA, PLA-PRU-PLA-PRU, PLA-PRU-PRU-PLA
- Where
- United Kingdom
- Sponsor
- Movetis
Ogilvie Syndrome, Colonic Pseudo-Obstruction
Epidural for Ogilvie's Syndrome
Epidural anesthesia may represent a safe and effective pharmacological tool in the management of Ogilvie's Syndrome. This pilot study aims to demonstrate feasibility, safety, and efficacy of epidural anesthesia to set the stage…
- Trial name
- NCT04600427
- Testing
- Epidural anesthesia
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Pseudo Obstruction
ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility
To assess the diagnostic yield of Sanger sequencing for ACTG2 and FLNA genes evaluation on blood or saliva sample in patients with idiopathic CIPO in which high-resolution esophageal manometry (HRM) shows reduced (DCI <450…
- Trial name
- CIPO_GEN (NCT07448753)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Marina Coletta
Gastroesophageal Reflux, Gastroparesis
Domperidone Expanded Access Protocol for Patients With Gastrointestinal Disorders
FDA currently allows patients 12 years of age and older with various gastrointestinal (GI) conditions to be treated with Domperidone through the Expanded Access to Investigational Drugs program.
- Conditions
- Gastroesophageal Reflux, Gastroparesis, Chronic Constipation With Overflow, Pseudo Obstruction
- Trial name
- NCT02567175
- Testing
- Domperidone
- Where
- United States
- Sponsor
- Prasanna K Kapavarapu
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Paralytic Ileus
Gum Chewing Reduces the Risk of Postoperative Ileus After Arthroplasty Procedures in The Elderly Population
Postoperative ileus (POI) is defined as a temporary cessation of bowel movement after a surgical procedure. Surgical procedures not only include abdominal or colorectal procedures but non-abdominal procedures as well.
- Trial name
- NCT04489875
- Testing
- Chewing Gum
- Volunteers
- 50 people
- Sponsor
- Indus Hospital and Health Network
Large Bowel Obstruction
Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery
The purpose of this study is to assess quality of life and bowel symptoms after treatment.The main objective is to compare the effect on quality of life of minimally invasive bowel surgery and endoscopic stent placement in the…
- Trial name
- NCT00140868
- Testing
- Luminal stents, Minimally Invasive Surgical Bowel Diversion
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Intestinal Pseudo-obstruction
Safety and Efficacy of Endoscopic Full Thickness Biopsy in Patients With Chronic Intestinal Pseudo-obstruction
To evaluate the safety and efficacy of endoscopic full thickness biopsy for the diagnostic purpose of chronic intestinal pseudo-obstruction.
- Trial name
- EFTB-CIPO (NCT06943417)
- Testing
- Over the scope clip
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- International University of Health and Welfare
Small Bowel Obstruction, Intestinal Pseudo-Obstruction
Predicting NOM Failure in Bowel Obstruction
"This study aims to collect data on patients with small bowel obstruction (SBO) admitted to hospitals in France and Italy from May 2022 to October 2024 to develop a deep convolutional neural network (DCNN) model.
- Trial name
- NCT06711107
- Where
- France
- Volunteers
- 370 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Chronic Intestinal Pseudo-Obstruction
Pseudo-obstruction Assessment With MRI
This study will explore the potential for a standardized MRI scan after a liquid meal to be used in diagnosis of the rare but debilitating chronic intestinal pseudo-obstruction (CIPO).
- Trial name
- POM (NCT04193735)
- Testing
- MRI scans after a liquid meal
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham
Gynecologic Disease, Postoperative Ileus
Postoperative Chewing Gum and Gynecological Laparoscopic Surgery
The authors aimed to evaluate the effects of postoperative gum chewing on laparoscopic gynecological surgery, gastrointestinal function-intestinal mobility and early postoperative recovery.
- Conditions
- Gynecologic Disease, Postoperative Ileus, Paralytic Ileus
- Trial name
- NCT03884244
- Testing
- chewing gum
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Paralytic Ileus
The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section
Following all abdominal surgery, paralytic ileus commonly develops. Surgeons have traditionally withheld postoperative oral intake until the return of bowel function to prevent related complications.
- Trial name
- GUM01 (NCT01131416)
- Testing
- Gum chewing
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Intestinal Pseudo-Obstruction, Manipulation, Osteopathic
Rib Raising for Post-operative Ileus
We are conducting a randomized controlled trial the use of rib raising for post-operative ileus. Rib raising is an osteopathic manipulative technique (OMT).
- Conditions
- Intestinal Pseudo-Obstruction, Manipulation, Osteopathic, Postoperative Care, Postoperative Nausea and Vomiting
- Trial name
- NCT03662672
- Testing
- Rib raising and lumbar release
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Rutgers, The State University of New Jersey
Irritable Bowel Syndrome
Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)
The purpose of this study is to determine the efficacy, safety, and tolerability of different doses of eluxadoline (JNJ-27018966) compared with placebo in the treatment of participants with diarrhea-predominant irritable bowel…
- Trial name
- NCT01553747
- Testing
- Eluxadoline
- Where
- 253 sites in United States, Canada and 2 more
- Volunteers
- 1,146 people
- Sponsor
- Furiex Pharmaceuticals, Inc
Complication, Postoperative
Early Initiation of Oral Feeding Versus Traditional Feeding Post Caesarean Section
Early initiation of oral feeding, within 6-12 hours post-caesarean section, has been noticed to be well tolerated by patients and helps them recover fast.
- Trial name
- NCT06539117
- Testing
- Early feeding post caesarean section
- Where
- Nigeria
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Paralytic Ileus
Effect of Preoperative Intrathecal Dexamethasone Versus Dexmedetomidine on Paralytic Ileus After Major Abdominal Surgery
Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.
- Trial name
- NCT06752317
- Testing
- Dexamethasone, Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Paralytic Ileus
Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Following extensive abdominal surgery for the treatment of endometrial or ovarian cancer, paralytic ileus frequently develops. Gum chewing can promotes the return of bowel function through the cephalic-vagal reflex and increased…
- Trial name
- NCT01389986
- Testing
- Gum chewing
- Where
- Thailand
- Sponsor
- Chiang Mai University
Hirschsprung's Disease Associated Enterocolitis
Neuro-Immune Interactions in the Gut
Hirschsprung's disease (HD) is diagnosed shortly after birth and is characterized by the presence of megacolon. HD is caused when ganglion cells of the enteric nervous system (ENS) in the wall of the large intestine do not…
- Trial name
- NIG (NCT03617640)
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel