Clinical trials: Psychiatric Disorder
Alcohol Use Disorder, Contingency Management
Dual Reinforcement Contingency Management for Alcohol Use Disorders
Phosphatidylethanol (PEth) is a direct biomarker of alcohol that can detect moderate to heavy drinking with high sensitivity and specificity over 3-week periods.
- Trial name
- Peth (NCT04064463)
- Testing
- Standard care, Contingency management
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- UConn Health
Postoperative Sleep Disturbances
Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality İn Rhinoplasty
Background Postoperative sleep disorders are common complications of surgery and anesthesia that prolong morbidity and hospital stay. Various methods are being explored to prevent and treat these issues.
- Trial name
- NCT06898463
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine), Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Konya City Hospital
Childbirth-related PTSD, PTSD
International Survey of Childbirth-Related Trauma - Swedish Part
The goal of this cross-sectional observational study is to analyze childbirth-related PTSD, traumatic birth experiences and stress symptoms postpartum.
- Conditions
- Childbirth-related PTSD, PTSD, Postnatal Depression, Fear of Childbirth
- Trial name
- SwIntersect (NCT06207916)
- Where
- Sweden
- Volunteers
- 619 people
- Sponsor
- Region Östergötland
Anxiety, Depression
Child STEPS for Youth Mental Health in Maine Sustainability
The overarching goal of this project is to study the sustainability of MATCH-ADTC within community mental health clinics, to learn what is needed for evidence-based practices (EBPs) to take root and thrive within a public system.
- Conditions
- Anxiety, Depression, Trauma, Behavior Problems
- Trial name
- NCT03112304
- Testing
- MATCH-ADTC, TRAC
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Harvard University
Social Anxiety Disorder
Efficacy of BNC210 in Acute, As-needed Treatment of Anxiety in Social Anxiety Disorder - 1
The purpose of the study is to evaluate the effect of a single, acute dose of BNC210 compared to placebo on reducing the severity of anxiety provoked by a behavioral assessment task and measured using the Subjective Units of…
- Trial name
- AFFIRM-1 (NCT06510504)
- Testing
- 225 mg BNC210
- Where
- 21 sites in United States
- Volunteers
- 370 people
- Sponsor
- Bionomics Limited
Bipolar Disorders, Schizophrenia
Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence.
- Conditions
- Bipolar Disorders, Schizophrenia, Schizoaffective Disorders, Alcohol Dependence
- Trial name
- vivitrol (NCT00453804)
- Testing
- injectable naltrexone, oral naltrexone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University
Impaired Processing Speed, Cognitive Impairment
Adderall XR and Processing Speed in Multiple Sclerosis (MS)
Cognitive impairment, or problems with thinking and memory, is common in multiple sclerosis (MS) and can occur independently of physical disability.
- Conditions
- Impaired Processing Speed, Cognitive Impairment, Multiple Sclerosis
- Trial name
- NCT01667484
- Testing
- Adderall XR 5mg, Adderall XR 10 mg
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- London Health Sciences Centre
ADHD - Attention Deficit Disorder With Hyperactivity, Bipolar Affective Disorder; Remission in
Psychophysiological Responses to Six Single-Session Self-Regulation Interventions in a Female Adult With ADHD and Stabilized Bipolar Disorder
This study aims to explore how six short, 15-minute self-regulation techniques affect the body and brain in a female adult with ADHD and stabilized bipolar disorder.
- Trial name
- NCT07437833
- Testing
- Moderate-Intensity Aerobic Exercise on Cycloergometer, Cyclic Sighing, Aromatherapy
- Where
- Poland
- Volunteers
- 1 people
- Sponsor
- Poznan University of Physical Education
Perceived Recovery
Effects of Wrestling Training on Psychological Well-Being, Anxiety, and Resilience in Adolescent Boys
This study employed a randomized pretest-posttest control group design. Both groups underwent baseline assessments before the intervention and post-tests after six weeks.
- Trial name
- NCT07373652
- Testing
- Wrestling training, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Bipolar Depression
Dopamine D3 Receptor Occupancy in Bipolar Depression
Bipolar disorder is a common condition that can cause significant disability and risk for suicide. Second generation antipsychotic medications can be used to treat depression in bipolar disorder, yet we do not know how they work.
- Trial name
- NCT05060549
- Testing
- Cariprazine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Alzheimer Disease
Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease
To investigate the safety of deep brain stimulation (DBS) and cervical deep lymphoid-venous anastomosis (LVA) in the treatment of severe Alzheimer's disease (AD); to investigate the effectiveness of DBS and LVA in the treatment…
- Trial name
- NCT07094438
- Testing
- Deep Brain Stimulation, DBS, Deep cervical lymphatic-venous anastomosis, LVA, Recognized pharmacological treatments for AD.
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Chinese PLA General Hospital
Alzheimer's Disease
A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease
The primary objective of the study is to determine the dose response of E2814, when concurrently administered with lecanemab, on the change from baseline at 6 months in cerebrospinal fluid (CSF) microtubule-binding region…
- Trial name
- NCT06602258
- Testing
- E2814, Lecanemab
- Where
- 26 sites in United States, Japan
- Volunteers
- 105 people
- Sponsor
- Eisai Inc.
Autism Spectrum Disorder
Feasibility and Safety of a Virtual-Reality Based Job Interview Training Tool in Teenagers With High-Functioning Autism
The current project involves the application of a VR job training software. We propose to use an interactive VR job interview practice system, Virtual Reality Job Interview Training (VR-JIT), in youths with ASD at the highschool…
- Trial name
- NCT04773548
- Testing
- VR-JIT
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Autism Spectrum Disorder, Parenting Stress
Feasibility and Acceptability of Laughter Yoga in Children With Autism Spectrum Disorder and Their Parents
This is a pilot randomised controlled trial to explore the acceptability and feasibility of laughter yoga about anxiety and depression reduction in children with ASD and parenting stress reduction for their parents.
- Conditions
- Autism Spectrum Disorder, Parenting Stress, Depression, Anxiety
- Trial name
- NCT06326255
- Testing
- laughter yoga
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- LAM Chung Yan Hemio
Chronic Insomnia
Safety and Efficacy of Ramelteon in Elderly Subjects With Chronic Insomnia
This purpose of this study is to evaluate the safety and effectiveness of Ramelteon, once daily (QD), in elderly participants with chronic insomnia.
- Trial name
- NCT00671255
- Testing
- Ramelteon
- Where
- 115 sites in United States, Canada
- Volunteers
- 829 people
- Sponsor
- Takeda
Major Depressive Disorder, Anxiety
The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
The purpose of this study is to determine whether vilazodone is more effective than citalopram for the treatment of anxious depression.
- Conditions
- Major Depressive Disorder, Anxiety, Comorbidity
- Trial name
- NCT02028026
- Testing
- Vilazodone, Citalopram
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Trauma, Psychological, Depression, Anxiety
The BEAR Therapeutic Program for Women
The current study aims to test a novel therapeutic intervention for women who have a history of interpersonal trauma. The Building Empowerment and Resilience (BEAR) Therapeutic group incorporates psychological skills…
- Conditions
- Trauma, Psychological, Depression, Anxiety, PTSD
- Trial name
- NCT04418778
- Testing
- BEAR
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Alcohol Use Disorder
Methylphenidate and Response to Alcohol Cues
The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues.
- Trial name
- NCT07306078
- Testing
- Methylphenidate Pill
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Substance Use Disorder (SUD), Anxiety
Behavioral Rigidity in Residential Treatment for Substance Use Disorder (RIG-TD)
Behavioral rigidity, the tendency to maintain inflexible patterns of thinking and acting despite changing circumstances, is a common feature in substance use disorders, depression, and anxiety.
- Conditions
- Substance Use Disorder (SUD), Anxiety, Depression Anxiety Disorder
- Trial name
- RIG-TD (NCT07590115)
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Lauro Gutiérrez Castro
Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy with or without hippocampal avoidance in reducing neurocognitive decline in patients with cancer that has spread from the primary site…
- Conditions
- Cognitive Impairment, Metastatic Malignant Neoplasm in the Brain, Solid Neoplasm
- Trial name
- NCT02360215
- Testing
- Whole brain radiation therapy with hippocampal avoidance, Memantine, Whole brain radiation therapy
- Where
- 220 sites in United States, Canada
- Volunteers
- 518 people
- Sponsor
- NRG Oncology