Clinical trials: Psychiatric Illness
Enrichment With Meaning-generating Activities, Rehabilitation as Usual
Enrichment of Day Centers in Community-based Psychiatry
This RCT study addresses the topic of improving the possibilities for people with severe mental illness (SMI) to be engaged in meaningful daily occupations at community-based activity (CBA) centers.
- Trial name
- NCT01732575
- Testing
- Enrichment with meaning-generating activities
- Volunteers
- 107 people
- Sponsor
- Lund University
Treatment-Resistant Depression, Bipolar Depression
Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression
The goal of this clinical trial is to evaluate the safety and initial effectiveness of MR-guided focused ultrasound (MRgFUS) bilateral capsulotomy in patients with treatment-resistant bipolar depression (TRBD).
- Trial name
- NCT07108257
- Testing
- ExAblate Neuro 4000
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
COVID-19, Cognitive Decline
Study of Epidemiologic Investigation and Mechanism of Brain Network of Otologic and Cognitive Function With Post-COVID-19
The purpose of this study was to analysis the incidence of ear symptoms, cognitive function decline and emotional disorders in Chinese people who were infected with COVID-19, exploring the impact of COVID-19 on the auditory…
- Conditions
- COVID-19, Cognitive Decline, Otological Disease
- Trial name
- COVID-19 (NCT05787301)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sleep Deprivation
Sleep Quality After Stellate-ganglion Block of Patients Undergoing Breast Cancer Operation
Stellate-ganglion block have been done safely for more than 60 years. It has proved to provide survivors of breast cancer with relief from hot flushes and sleep dysfunction with few or no side-effects.
- Trial name
- NCT02651519
- Testing
- 0.25% ropivacaine hydrochloride, saline
- Where
- China
- Volunteers
- 105 people
- Sponsor
- China Medical University, China
Cognitive Decline
Multicomponent Program for Addressing Cognition in Rural Communities
The study is designed to develop and evaluate a multicomponent intervention program among older rural-residing and African American residents with a long-term goal of reducing risk factors for Alzheimer's disease.
- Trial name
- MPAAC-R (NCT07018830)
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Core Temperature, Telomere Length, Mean Leukocyte
Mitigating Heat Stress Among Rickshaw Drivers in Bangladesh
The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign…
- Conditions
- Core Temperature, Telomere Length, Mean Leukocyte, Kidney Function Issue
- Trial name
- NCT06956430
- Testing
- Battery-powered rickshaw
- Volunteers
- 300 people
- Sponsor
- University of California, Berkeley
Schizophrenia
The Effectiveness and Efficacy of the Combination of the Integrated Psychological Therapy and Metacognitive Training.
The combination of the Integrated Psychological Therapy and Metacognitive Training in individuals with schizophrenia and treatment resistant schizophrenia. Is it effective and efficacious?
- Trial name
- ATHSCHIZ (NCT05623228)
- Testing
- The combination of the Integrated Psychological Therapy and Metacognitive Training in individuals with schizophrenia and treatment resistant schizophrenia
- Where
- Greece
- Volunteers
- 35 people
- Sponsor
- Rakitzi, Stavroula
Irritability Associated With Autism Spectrum Disorder (ASD)
Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder
The purpose of this study is to find out about the potential benefits and safety of brexpiprazole in children and adolescent participants, aged 5 to 17, with irritability associated with autism spectrum disorder.
- Trial name
- NCT04174365
- Testing
- Brexpiprazole
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Dementia Associated With Parkinson's Disease, Dementia With Lewy Bodies
Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB)
A 24-week placebo-controlled parallel group multicentre trial to study the safety and efficacy of memantine in patients with dementia associated with Parkinson's disease and dementia with Lewy bodies.
- Trial name
- MEMPDD (NCT00630500)
- Testing
- Memantine
- Where
- 4 sites in Norway, Sweden and 1 more
- Volunteers
- 75 people
- Sponsor
- Helse Stavanger HF
Alzheimer's Disease
A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology
The primary purpose of this study is to identify participants with or without symptoms of Alzheimer's Disease (AD) that are at high risk for brain amyloid pathology using blood-based biomarkers.
- Trial name
- NCT06043700
- Testing
- No Intervention
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Eisai Limited
Huntington Disease
Benchmarking Integrated Care for People Living With Huntington's Disease in England
The survey and full study information can be accessed here: https://southampton.qualtrics.com/jfe/form/SV_8iEedDJZy4xaiI6 The goal of this anonymous survey is to benchmark integrated care from the perspective of service users in…
- Trial name
- Integrate-HD (NCT05828992)
- Testing
- No intervention administered
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Major Depressive Disorder
Developing New Clinical Management Strategies
The goal of this study is to develop new methods of administering antidepressant medications that will result in improved drug/placebo separation in randomized controlled trials (RCTs) for Major Depressive Disorder (MDD) and…
- Trial name
- NCT02082392
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York State Psychiatric Institute
Depression, Major Depressive Disorder
pBFS-guided High-dose TMS Over DMPFC for Treatment-resistant Major Depressive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided DMPFC target and high-dose rTMS therapy for the treatment of patients with treatment-resistant depression
- Conditions
- Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05964036
- Testing
- active TMS
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Changping Laboratory
Chronic Heart Failure, Obstructive Sleep Apnea
CPAP and Physiotherapy for Heart Failure and Sleep Apnea in the Elderly
This study evaluates whether adding physiotherapy (including herbal medicine, acupuncture, and Tuina massage) to standard continuous positive airway pressure (CPAP) therapy can provide superior benefits compared to CPAP alone for…
- Trial name
- NCT07061171
- Testing
- Continuous Positive Airway Pressure, Herbal Decoction, Acupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Weihua Peng
Cocaine Dependence
Complementary Combination Therapy for Cocaine Dependence
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers.
- Trial name
- NCT02538744
- Testing
- Doxazosin, Modafinil, cocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy
The goal of this phase II/III randomized clinical trial is to evaluate the effect of adding rectal ozone therapy to the usual management of patients with paresthesia (numbness and/or tingling) due to chemotherapy-induced…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQT (NCT06706544)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Barrett Esophagus, Anorexia Nervosa, Binge Eating/Purging Type
Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype
To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors
- Conditions
- Barrett Esophagus, Anorexia Nervosa, Binge Eating/Purging Type, Rumination, Vomiting
- Trial name
- NCT06532734
- Testing
- EsoGuard
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Denver Health and Hospital Authority
Posttraumatic Stress Disorder
GAMBIT Task With PTSD and Healthy Control Participants
This is a pilot study of a digital training task called GAMBIT. This study will be the first to examine potential relationships between GAMBIT task completion and brain circuit flexibility, behavior, and symptoms in participants…
- Trial name
- GAMBIT (NCT05313334)
- Testing
- GAMBIT Task
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Multi-Country Observational Study to Collect the Frequency of Sexual Dysfunction With Antidepressant Treatment, Either With SSRIs or Duals at 8 Weeks and 6 Months
In usual clinical conditions, depressed patients with no sexual dysfunction, after signing their consent for the dissemination of their clinical information will begin their treatment with any SSRI or a Dual antidepressant as per…
- Trial name
- NCT00561509
- Testing
- SSRIs, Dual antidepressants
- Where
- 57 sites in Austria, China and 11 more
- Volunteers
- 1,626 people
- Sponsor
- Eli Lilly and Company
Obsessive-Compulsive Disorder
Art Therapy in an Intensive OCD Program
The Thompson Centre Intensive Treatment program for individuals with severe Obsessive-Compulsive Disorder was launched in 2017. The program is focused on the principles and use of Exposure and Response Prevention Therapy (ERP)…
- Trial name
- NCT05855902
- Testing
- group art therapy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
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