Clinical trials: Psychological
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Subjects With Hyperlipidemia, Dyslipidemia and HIV Infection
Safety, Tolerability and Efficacy on Low Density Lipoprotein Cholesterol (LDL-C) of Evolocumab in Participants With Human Immunodeficiency Virus (HIV) and Hyperlipidemia/Mixed Dyslipidemia
The study is divided into 2 parts. The first part of the study will be double-blinded and will last for 24 weeks. During this time, participants will be randomized in a ratio of 2:1 to receive either evolocumab once monthly (QM)…
- Trial name
- NCT02833844
- Testing
- Evolocumab
- Where
- 78 sites in United States, Australia and 13 more
- Volunteers
- 467 people
- Sponsor
- Amgen
Premature Ejaculation
A Safety and Efficacy Study of OnabotulinumtoxinA in Premature Ejaculation
This is a safety and efficacy study of OnabotulinumtoxinA for the treatment of premature ejaculation (PE) in male participants.
- Trial name
- NCT01917006
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 59 people
- Sponsor
- Allergan
Erectile Dysfunction
Evaluation of the 2005 AMS (American Medical System) IPP (Inflatable Penile Prosthesis)
The purpose of this study is to evaluate modifications to the AMS 700 Series pump, cylinders, reservoir and rear tip extender design, their impact on ease of use for the patient, and ease of implantation for the physician.
- Trial name
- NCT00636506
- Testing
- AMS 700 IPP with MS Pump
- Where
- 7 sites in United States
- Volunteers
- 76 people
- Sponsor
- American Medical Systems
Well-Being, Sleep
Oregon Military Employee Sleep and Health Study
This study is a randomized controlled trial that assesses the effects of (1) the Family-Supportive Supervisor Behavior (FSSB) and Sleep Leadership training and (2) sleep/cognitive effectiveness feedback intervention on health and…
- Conditions
- Well-Being, Sleep, Health Behavior
- Trial name
- MESH (NCT02946736)
- Testing
- FSSB/Sleep Leadership Training, Actigraphy Feedback
- Where
- United States
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parenting, Mother-child Relations
Collaborative Perinatal Mental Health and Parenting Support in Primary Care
Treating mothers' perinatal depressive and other mental health symptoms alone does not prevent impaired parenting quality and adverse infant outcomes.
- Trial name
- NCT02724774
- Testing
- Promoting First Relationships®
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- University of Washington
Hypogonadism, Erectile Dysfunction
Testosterone for Penile Rehabilitation After Radical Prostatectomy
The purpose of this study is to determine the effectiveness of testosterone replacement therapy (TRT) in men following surgery to remove the prostate in improving erectile function.
- Trial name
- NCT00848497
- Testing
- Testim®, Viagra®
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mohit Khera
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Stress, Emotional, Sleep
A Study to Asses Wellness Using a Brain Sensing Device on Physicians
A study to asses the feasibility of physicians using a wearable brain sensing wellness device during a time of increased work load, patient volume and stressors to assess the association between duration of active state and calm…
- Conditions
- Stress, Emotional, Sleep, Quality of Life
- Trial name
- NCT04743973
- Testing
- Muse S™ Headband system
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Anxiety, Burn Out
A Study to Assess Virtual Reality by Healthcare Providers: A Pilot Study
The purpose of this study is to evaluate the acceptability of using Virtual Reality intervention to help reduce anxiety and burnout symptoms and improve focus in the workplace.
- Trial name
- NCT04622527
- Testing
- Random assigned paradigm viewing order
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Psychotic Disorders, Obesity
Web-Based Delivery of MOVE! to Veterans With Serious Mental Illness (SMI)
Obesity and physical inactivity have reached epidemic proportions, resulting in increased rates of a variety of chronic diseases, increased risk of death, and substantial health care costs.
- Conditions
- Psychotic Disorders, Obesity, Health Behaviors
- Trial name
- Web-MOVE! (NCT00983476)
- Testing
- in-person MOVE! SMI, web-based MOVE! SMI
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- VA Office of Research and Development
Mental Health, Neurology
Implementing Evidence in the Detection and Treatment of Post Stroke Depression
Post Stroke Depression (PSD)is a high volume condition with negative impact on patient recovery after stroke. The primary aim of this study is to evaluate the effectiveness of a system intervention to improve the proportion of…
- Conditions
- Mental Health, Neurology, Health Services
- Trial name
- NCT00296140
- Testing
- self management of PSD symptoms, screening and treatment of PSD
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Mental Disorders
Mechanisms of Action and Outcome
The objective of this study is to examine the mechanisms of action and outcome in mental health peer support groups. The study design is a randomized trial in which participants are assigned to one of three study arms: a recovery…
- Trial name
- Peer Support (NCT00555568)
- Testing
- recovery oriented mental health peer support group, recovery-oriented mental health clinician-led group
- Where
- 2 sites in United States
- Volunteers
- 298 people
- Sponsor
- US Department of Veterans Affairs
PTSD, Depression
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care
OEF/OIF/OND war Veterans have unique post-deployment care needs that the VA is striving to understand and address. Unfortunately, there is a significant disparity in utilization of mental health (MH) care and VA access as most…
- Conditions
- PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
- Trial name
- eSDM (NCT03539068)
- Testing
- WEB-ED+ Treatment Arm
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- VA Office of Research and Development
Military Personnel, Family Members
Telephone Support During Overseas Deployment for Military Spouses
Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression.
- Conditions
- Military Personnel, Family Members, Resilience, Psychological, Deployment
- Trial name
- NCT01828983
- Testing
- Telephone support groups, Education webinars
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Memphis VA Medical Center
Depressive Symptoms, Stress, Psychological
Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being
Caregivers suffer great amounts of distress that significantly impacts their mental and physical well-being, yet caregivers' access to quality, evidence-based care is currently very limited.
- Trial name
- NCT03506945
- Testing
- mPEP, Bibliotherapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Dementia, Quality of Life
Caring for Caregivers and People Living With Dementia Under Home-Based Primary Care
The goal of this clinical trial is to develop a dementia care intervention for persons receiving home-based primary care (HBPC) and living with dementia (PLWD) and their caregivers, and test the feasibility of implementing the…
- Conditions
- Dementia, Quality of Life, Caregiver Stress
- Trial name
- NCT05849259
- Testing
- Dementia Care Quality at Home
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Osteoarthritis
Enhancing Well-Being Through Exercise During Old Age
Determine the feasibility of adapting Fit \& Strong!, an evidence-based group physical activity and health education program, to include affect and mood-related content and of employing this intervention among older adults with a…
- Trial name
- NCT04536727
- Testing
- Fit & Strong!, Wait list
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago