Clinical trials: Psychoses, Manic-Depressive
Sleep Initiation and Maintenance Disorders
A Double-blind, Group-comparison P-III Study With Zolpidem MR Using Placebo and Nitrazepam in Insomnia Patients
A multicenter, randomized, double-blind, triple-dummy, group-comparison study using placebo and nitrazepam as a comparative drug.
- Trial name
- NCT00374777
- Testing
- zolpidem MR, nitrazepam
- Where
- 6 sites in Japan
- Volunteers
- 450 people
- Sponsor
- Astellas Pharma Inc
Schizophrenia, Schizoaffective Disorder
Estimating and Reducing the Cardiovascular Risk of Patients With Schizophrenia Drugs From Lipid Measures and Ischemic Electrocardiographic Changes
The primary goal of this study is to examine the triglyceride/high-density lipoprotein (TG/HDL) ratio and the ischemic EKG changes in patients with schizophrenia, schizoaffective disorder or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00288353
- Testing
- aripiprazole (Abilify), ziprasidone (Geodon)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Northwestern University
Serious Mental Illness
Home-based Exercise for SMI
Older Veterans with serious mental illness (schizophrenia, schizoaffective disorder, bipolar disorder) have reduced physical function (endurance, strength, mobility) that leads to lower quality of life.
- Trial name
- NCT06078293
- Testing
- Home-based Exercise Program
- Where
- United States
- Sponsor
- VA Office of Research and Development
Covid19, Severe Mental Disorder
COVID-19 Serological Testing of Patients With a Mental Disorder From the Catchment Area of the Capital Region of Denmark
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has lately caused worldwide health problems.
- Trial name
- NCT04775407
- Testing
- blood sampling
- Where
- Denmark
- Volunteers
- 1,355 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Schizophrenia, Bipolar Disorder
Psychosocial Intervention to Reduce Self-stigma and Improve Quality of Life Among People With Mental Illness in Chile
The principal objective of this pilot trial is to evaluate the effectiveness of a psychosocial intervention to reduce self-stigma and improve treatment adherence and quality of life among people with a severe mental illness who…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03197168
- Testing
- Intervention to reduce self-stigma among people with mental illness, Control
- Where
- Chile
- Volunteers
- 76 people
- Sponsor
- University of Chile
Schizophrenia, Schizoaffective Disorder
An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
The aim of this study is to evaluate the effectiveness, safety, and tolerability of metformin treatment in children and adolescents suffering from weight gain secondary to use of atypical antipsychotic medications.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar Disorder
- Trial name
- NCT00391261
- Testing
- Metformin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cambridge Health Alliance
Major Depression, Bipolar Disorder
Assessing the Impact of Self-directed Care, Within a Medicaid-funded Environment,on Participation and Community Living
This project proposed to demonstrate the effectiveness, costs, and benefits to participation and community living self-directed care programming within a financially sustainable Medicaid managed care environment.
- Conditions
- Major Depression, Bipolar Disorder, Schizophrenia
- Trial name
- NCT02520024
- Testing
- self-directed care
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Temple University Collaborative on Community Inclusion
Bipolar Disorder, Personality Disorders
The Role of Group Identity on the Community Integration of People With Severe Mental Disorder
This study analyzes which variables enhance or hinder community integration among people with severe mental disorder. Participants will complete a questionnaire to test our hypotheses: Hypothesis 1: group identification predicts…
- Conditions
- Bipolar Disorder, Personality Disorders, Psychotic Disorders
- Trial name
- NCT04304417
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Universidad Complutense de Madrid
Agitation
Phase IV to Evaluate the Safety of Self-administered ADASUVE® in Agitated Patients Outside the Hospital Setting
Phase IV, multinational, multicentre, open-label, non-randomized, clinical trial conducted in Europe (Spain, Germany, Finland, Norway, Romania and Austria) to evaluate the safety profile of ADASUVE® in agitated patients with…
- Trial name
- NCT02525991
- Testing
- Staccato® Delivery System Loxapine (ADASUVE®)
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Ferrer Internacional S.A.
Bipolar Disorder, Schizophrenia
Immuno-Genetic, Inflammation, Retro-Virus, Environment
Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far missing in psychiatry, and to design innovative treatment approaches based on the discovery of new molecular and cellular targets.
- Trial name
- I-Give (NCT02878408)
- Testing
- Blood sampling
- Where
- 6 sites in France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Pr. Marion Leboyer
Schizophrenia, Schizoaffective Disorder
Comparing Thinking Skills for Work (TSW)Home Practice Program With Traditional TSW Program
The purpose of this study is to determine if using a tablet computer, which is a very small, easy-to-carry computer, to practice thinking exercises at home will help improve your attention, memory, and problem solving abilities.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT03005574
- Testing
- TSW-HP, TSW-T
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston University Charles River Campus
Psychiatric Disorder, Schizophrenia
Improving Physical Health in Patients With Psychiatric Disorders in General Practice (SOFIA)
People with a severe mental illness (SMI) have an increased risk for premature mortality, predominantly due somatic health conditions.
- Conditions
- Psychiatric Disorder, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- SOFIA (NCT04618250)
- Testing
- SOFIA model
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Copenhagen
Schizophrenia, Bipolar Disorder
Assertive Community Treatment in Copenhagen
The aim of the study is to evaluate the effect of assertive community treatment in Copenhagen in two regions compared with two regions where this treatment was not implemented.
- Trial name
- NCT00225602
- Testing
- Assertive Community Treatment, Treatment in Community Mental Health Center
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Bispebjerg Hospital
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Mental Illness, Schizophrenia
Walking for Health: an Intervention to Increase Physical Activity and Reduce Sedentary Behaviour in People With SMI
People who have a severe mental illness can have poorer physical health and higher mortality rates than the general population. Their medications combined with low levels of physical activity and increased sedentary behaviour can…
- Conditions
- Mental Illness, Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- WORtH (NCT04134871)
- Testing
- Group walk and one to one coaching
- Where
- 3 sites in Ireland, United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Ulster
Schizophrenia, Major Depression
Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core
Background: The Human Brain Collection Core (HBCC) collects brain and other tissues. They get these from deceased people who may or may not have had psychiatric disorders.
- Conditions
- Schizophrenia, Major Depression, Bipolar Disorder, PTSD
- Trial name
- NCT03092687
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Affective Disorder
Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder
Bipolar affective disorder or manic -depressive psychosis (MDP) is a mood disorder affecting 2.4% of the global population . Lithium is considered as the "gold standard" for the treatment of bipolar disorder but the clinical use…
- Trial name
- NCT04222816
- Testing
- Lithium Carbonate, Sodium chloride
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Bipolar Disorder
A Study to Evaluate the Effectiveness and Safety of Extended-Release (ER) Paliperidone Compared With Placebo in Delaying the Recurrence of Symptoms in Bipolar I Disorder
The purpose of this study is to evaluate the effectiveness and safety of oral extended-release (ER) paliperidone compared with placebo in the prevention of the recurrence of mood symptoms in patients with Bipolar I Disorder who…
- Trial name
- NCT00490971
- Testing
- Olanzapine, Paliperidone ER
- Where
- 78 sites in United States, Bulgaria and 14 more
- Volunteers
- 768 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Comparing Hospitalisation Time With Seroquel and Seroquel Prolong
Nis Register Study Comparing Seroquel and Seroquel Prolong
The general aim of this non interventional study is to clarify what are the current clinical treatment practices of Quetiapine Immediate Release and Quetiapine Extended Release.
- Trial name
- NCT00965536
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development