Clinical trials: Psychoses, Manic-Depressive
Emotional Dysregulation
Patients Suffering From Emotional Dysregulation
Emotional dysregulation (ED) is a common syndrome in psychiatric disorders. It is characterized by intense emotions, easily triggered, and with significant psychological impact: explosions of anger, irritability, impulsivity…
- Trial name
- Dys-Emotion (NCT06616337)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Schizophrenia, Bipolar Disorder With Psychosis
Remote Cognitive Remediation
With medication, many individuals with psychosis experience a remission from hallucinations and delusions, the most salient aspects of the disorders.
- Trial name
- NCT02121106
- Testing
- Cognitive Remediation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Queen's University
Schizophrenia, Bipolar Disorder
Using Motivational Techniques to Increase Levels of Physical Activity in Long Term Psychiatric Inpatient Wards
The current research project aims at investigating whether it is possible to obtain an increase in physical activity among inpatients with schizophrenia spectrum disorders by the use of motivational interviewing and environmental…
- Conditions
- Schizophrenia, Bipolar Disorder, Inpatient Facility Diagnoses, Cardiovascular Risk Factor
- Trial name
- FYSAKT (NCT03528278)
- Testing
- Motivational interviewing and environmental interventions
- Where
- 2 sites in Norway
- Volunteers
- 83 people
- Sponsor
- Oslo University Hospital
Schizophrenia, Bipolar Disorder
Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease
The validation of biomarkers allowing the discrimination of cognitive and behavioral disorders of psychiatric origin from those of neurodegenerative origin would facilitate diagnosis and improve patient management.
- Conditions
- Schizophrenia, Bipolar Disorder, Alzheimer Disease, FTD
- Trial name
- Nfl_COG (NCT04946916)
- Testing
- blood sample taken
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia, Schizoaffective Disorder
Improving Antipsychotic Adherence Among Patients With Serious Mental Illness
This is a randomized controlled trial examining the effectiveness of a pharmacy-based intervention designed to improve adherence with antipsychotic medications among patients with serious mental illness.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00057135
- Testing
- Unit of use medication packaging, Mailed reminders to patient when medication refills are due, Note to Mental Health Provider when refill is overdue
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- US Department of Veterans Affairs
Bipolar Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental III Health
A single-blinded hybrid effectiveness-implementation trial (Type II), that both evaluates the intervention outcomes (clinical and service use outcomes) through patient-randomization in the implementation sites, as well as…
- Conditions
- Bipolar Disorder, Schizophrenia, Severe Depression
- Trial name
- RECOVER-E (NCT03922425)
- Testing
- Community mental health team
- Where
- Bulgaria
- Volunteers
- 180 people
- Sponsor
- The National Center for Public Health and Analyzes, Bulgaria
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Bipolar Disorder, Affective Disorders, Psychotic
A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder
The purpose of this study is to determine the safety and efficacy of topiramate in adolescents with manic or mixed episodes of Bipolar I Disorder.
- Conditions
- Bipolar Disorder, Affective Disorders, Psychotic, Mood Disorders, Mental Disorders
- Trial name
- NCT00035802
- Testing
- Topiramate
- Volunteers
- 13 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Treatment Adherence and Compliance, Severe Mental Disorders
Medication Adherence in Severe Mental Illness: a Promotion Program
People living with serious mental illnesses such as schizophrenia and bipolar disorder often need long-term medication to stay well.
- Conditions
- Treatment Adherence and Compliance, Severe Mental Disorders, Bipolar Disorder (BD), Schizophrenia Disorder
- Trial name
- ADHERA (NCT07445802)
- Testing
- Telehealth Psychoeducational Adherence Program
- Volunteers
- 1,640 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Schizophrenia, Bipolar Disorder
A Biological Signature for the Early Differential Diagnosis of Psychosis
Schizophrenia (SZ) and mood disorders (BD, MDD) are among the most disabling disorders worldwide, with a relevant social, functional, and economic burden.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT06515522
- Testing
- differential diagnosis
- Volunteers
- 1,850 people
- Sponsor
- IRCCS San Raffaele
Severe Mental Illness, Schizophrenia
Reduction of Cardiovascular Risk in Severe Mental Illness
Background: Patients with severe mental illness (SMI) have a higher prevalence of cardiovascular risk factors (CVRF) than the general population and a control of these risk factors poorer.
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder, Affective Disorders
- Trial name
- RISCA-TMS (NCT01182012)
- Testing
- Lifestyle counseling
- Where
- Spain
- Volunteers
- 391 people
- Sponsor
- Consorci Hospitalari de Vic
Mental Disorder
Validation of Instruments for Clinical Trial on Patients With Bipolar Disorder in Rwanda
This study evaluates the cultural and linguistic sensitivity and psychometric properties of a set of four adapted measurement instruments essential to determining the efficacy of group-psychoeducation for patients with bipolar…
- Trial name
- NCT04834999
- Testing
- Validation of questionnaires in Kinyarwanda
- Where
- Rwanda
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Schizophrenia, Bipolar Disorder
Self and Body-esteem in Socio-professional Rehabilitation
The body esteem influences the physical appearance, which can be a social brake. To enhance the socio-professional insertion of persons with severe mental disorders, the investigators developed a group program about…
- Conditions
- Schizophrenia, Bipolar Disorder, Personality Disorders, Anxiety Disorders
- Trial name
- IPS_FIRAH (NCT04436757)
- Testing
- IPS program : Self-image and body representation, TAU
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hôpital le Vinatier
Mood Disorders, Psychotic Disorders
Family-Focused Therapy for Youth With Early-Onset Bipolar or Psychotic Disorders
The present study aims to : 1. compare different approaches (high intensity vs. low intensity) to training community providers (those who routinely treat young patients with bipolar disorder, psychosis, or sub-threshold high-risk…
- Trial name
- FFT (NCT02097563)
- Testing
- High Intensity Training, Low Intensity Training
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of California, Los Angeles
Depressive Disorder, Major, Bipolar Disorder
In-person vs. Remote Wellness Support
The study team will use components of the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework to compare Cognitive Adaptation Training (CAT) to Remotely delivered Cognitive Adaptation Training (R-CAT)…
- Conditions
- Depressive Disorder, Major, Bipolar Disorder, Schizo Affective Disorder, Schizophrenia
- Trial name
- R-CAT (NCT04526067)
- Testing
- CAT, R-CAT
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Schizophrenia, Bipolar Disorder
Restoration of Cognitive Function With TDCS and Training in Serious Mental Illness
Development of interventions that can effectively target and remediate the cognitive and functional impairment associated with serious mental illness is a treatment priority.
- Conditions
- Schizophrenia, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- NCT03208036
- Testing
- TDCS, Cognitive Remediation, Bridging Group
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Major Depression
Effectiveness of mHealth Post-discharge Intervention for Patients With Severe Mental Illness
The overall aim of this program of research is to improve the continuity of care for patients with serious mental illness (SMI) by supporting a safer and more efficient bridge from hospital to outpatient care using a mobile…
- Conditions
- Bipolar Disorder, Major Depression, Schizophrenia
- Trial name
- tFOCUS (NCT05703412)
- Testing
- Transition-FOCUS mHealth Intervention, Check-In
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Butler Hospital
Psychosis, Schizophrenia
Assessing the Effectiveness of Acceptance and Commitment Therapy for Distress Following Psychosis
This research investigates a new talking therapy aimed at helping people to come to terms with the experience of psychosis. The new therapy is called Acceptance and Commitment Therapy for psychosis (PACT).
- Conditions
- Psychosis, Schizophrenia, Bipolar Disorder, Schizo-affective Disorder
- Trial name
- PACT (NCT01003132)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Glasgow
Schizophrenia, Bipolar Disorder
Lurasidone Extended Use Study
This is an open-label continuation study designed to monitor the safety, tolerability and effectiveness of lurasidone in subjects who have completed participation in a lurasidone extension study (NCT00868959 and NCT01566162) and…
- Trial name
- NCT01485640
- Testing
- Lurasidone
- Where
- 46 sites in Canada, Colombia and 10 more
- Volunteers
- 162 people
- Sponsor
- Sumitomo Pharma America, Inc.