Clinical trials: Psychoses, Substance Induced
Cannabis, Ketamine
THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis
The aim of the research protocol is to evaluate cannabinoid-glutamate interactions in humans. As part of this aim the investigators will assess the safety and tolerability of the combination of NMDA antagonist, ketamine, and the…
- Trial name
- NCT04199468
- Testing
- Active Delta-9-THC, Active Ketamine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
Schizophrenia, Alcohol Use Disorder
A Study of ALKS 3831 in Subjects With Schizophrenia and Alcohol Use Disorder
This double-blind, randomized study will evaluate the efficacy, safety and tolerability of ALKS 3831 in subjects with schizophrenia and alcohol use disorder (AUD).
- Trial name
- NCT02161718
- Testing
- Samidorphan + olanzapine (ALKS 3831)
- Where
- 71 sites in United States, Bulgaria and 1 more
- Volunteers
- 300 people
- Sponsor
- Alkermes, Inc.
Schizophrenia and Disorders With Psychotic Features, Mood Disorders
Implementation and Evaluation of a Family-based Intervention Program for Children of Mentally Ill Parents
In order to identify psychological stress in children and adolescents of mentally ill parents as early as possible, a special intervention program (CHIMPs = Children of mentally ill parents) was developed.
- Conditions
- Schizophrenia and Disorders With Psychotic Features, Mood Disorders, Neurotic Disorders, Personality Disorders
- Trial name
- CHIMPs (NCT02308462)
- Testing
- CHIMPS intervention
- Where
- 14 sites in Germany, Switzerland
- Volunteers
- 400 people
- Sponsor
- Silke Wiegand-Grefe, Prof. Dr.
Dual Diagnosis, Psychosis
VR Based Therapy to Treat Anxiety in Dual Diagnosis
Dual diagnosis refers to patients with both severe mental illness and substance abuse. Dual diagnosis is therefore a challenging condition to treat, and the group typically represents the most vulnerable individuals in society.
- Conditions
- Dual Diagnosis, Psychosis, Agoraphobia, Social Anxiety Disorder
- Trial name
- NCT06315660
- Testing
- Cognitive Miljeu Therapy, Virtual Reality based CBT for Anxiety
- Volunteers
- 30 people
- Sponsor
- Mental Health Centre Sct. Hans
Psychotic Disorders, Cannabis Use Disorder
RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic Disorders
The goal of this clinical trial is to conduct a single-blind randomized controlled trial to verify whether the Avatar Intervention has greater efficacy over supportive intervention to reduce cannabis use in patients with…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Mental Health Disorder
- Trial name
- AC2 (NCT05704582)
- Testing
- Avatar Intervention, Addiction supportive intervention
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Expanded Game Squad for Neurodiverse Youth
The proposed study will pilot the use of an adapted Game Squad intervention aimed at improving physical activity and other important health behaviors (nutrition, sleep hygiene, screen time habits) for children and adolescents…
- Conditions
- Physical Activity, Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Health Behavior, Developmental Disorder
- Trial name
- NDGameSquad (NCT03665415)
- Testing
- NDGameSquad
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merrimack College
Alcohol Dependence, Bipolar Disorder
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
The study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their…
- Conditions
- Alcohol Dependence, Bipolar Disorder, Depression, Mania
- Trial name
- NCT01015586
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
Schizophrenia, Alcoholism
Risperidone and Desipramine in Alcohol Use and Schizophrenia
Note: In June 2013, the study design was changed from a randomized controlled study of risperidone + despiramine vs. risperidone vs. placebo to an open label pre-post study of risperidone (or risperidone-like drug) + desipramine.
- Conditions
- Schizophrenia, Alcoholism, Dual Diagnosis
- Trial name
- RADIAUS (NCT01411085)
- Testing
- Risperidone + Desipramine
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis, Psychotic Disorders
Cannabinoids, Neural Synchrony, and Information Processing
The study examines the effects of delta-9-tetrahydrocannabinol (Δ9-THC), the principal active ingredient of cannabis, on neural synchrony. Neural synchrony is studied using electroencephalography (EEG).
- Trial name
- THC-Gamma (NCT00708994)
- Testing
- THC
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Alcoholism
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
The investigators will conduct a 12-week, randomized, double-blind, parallel-group, placebo-controlled study of aripiprazole in 132 persons with Alcohol Use Disorder (AUD) and bipolar I or II disorder, currently depressed or…
- Conditions
- Bipolar Disorder, Alcoholism, Alcohol Abuse
- Trial name
- NCT02918370
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 2 Diabetes Mellitus, Schizophrenia
Lifestyle Intervention for Diabetes and Weight Management in Psychosis
The rate of type-2 diabetes mellitus (T2DM) is at least 2-3 times higher in persons with psychotic illnesses than in the general population.
- Conditions
- Type 2 Diabetes Mellitus, Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- Healthy_LIFE (NCT01828931)
- Testing
- Lifestyle Intervention, Usual Care
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health
None Volunteer
An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
The study team is studying how delta-9-tetrahydrocannabinol (THC) - the component of cannabis that is responsible for "getting people feeling high" - influences how people think about the behaviour of others and a variety of…
- Trial name
- NCT07878130
- Testing
- Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Psychosis, Cannabis Use Disorder
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
People suffering from psychosis who use cannabis experience more relapses, long and compulsory admissions, with huge costs to the individual, families and health services.
- Conditions
- Psychosis, Cannabis Use Disorder, First Episode Psychosis (FEP)
- Trial name
- CCP RCT (NCT07245212)
- Testing
- CCP Intervention
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- King's College London
Alcoholism, Schizophrenia
Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid Alcoholism
This placebo-controlled study is designed to evaluate the efficacy of glycine, an agonist of the glycine-B co-agonist site of the NMDA receptor, on alcohol consumption and craving as well as negative symptoms in schizophrenia.
- Trial name
- NCT00338598
- Testing
- Glycine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Substance-Related Disorders, Mental Disorder
Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up…
- Conditions
- Substance-Related Disorders, Mental Disorder, Social Stigma, Depression
- Trial name
- Siyakhana (NCT05282173)
- Testing
- Siyakhana CHW Training
- Where
- South Africa
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Dual Diagnosis
Cannabidiol for Treatment of Non-affective Psychosis and Cannabis Use
This trial examines the efficacy of cannabidiol (CBD) versus risperidone for treatment of psychosis in patients with non affective-psychosis and lifetime use of cannabis.
- Trial name
- NCT04105231
- Testing
- Cannabidiol, Risperidone
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Lone Baandrup
Schizophrenia Spectrum Disorders, Cannabis Use
Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis
A large proportion of people with a schizophrenia-spectrum disorder, especially in the early stages of the disease, regularly consume cannabis.
- Trial name
- NCT03883360
- Testing
- Cannabidiol (CBD)
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore
Psychotic Disorders, Forensic Psychology
Illness Management and Recovery- a Cluster Randomized Controlled Trial Within a Forensic Mental Inpatient Setting
The purpose of the study is to investigate the effects of a psychoeducational intervention program, Illness Management and Recovery (henceforth abbreviated as IMR), when administered to inpatient forensic mental health patients.
- Conditions
- Psychotic Disorders, Forensic Psychology, Forensic Nursing, Antisocial Personality Disorder
- Trial name
- NCT04695132
- Testing
- Illness Management and Recovery treatment programme
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy
Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I
The overall purpose of this study is to examine the effect of Pregnenolone (PREG) on the acute psychosis-like and cognitive effects of Delta-9-Tetrahydrocannabinol (THC).
- Trial name
- THC-PREG-I (NCT02811939)
- Testing
- Active Dronabinol, Active Pregnenolone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Yale University