Clinical trials: Psychosis, open to volunteers
Cannabis Use, SCHIZOPHRENIA
Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia
The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis.
- Conditions
- Cannabis Use, SCHIZOPHRENIA, Psychosis, rTMS
- Trial name
- NCT07196462
- Testing
- 3 Minute iTBS to the L DLPFC, One-Minute, Personalized, DMN Targeted CTBS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Behavior, Child, Child Development
Vulnerability/Resilience Factors Influencing the Developmental Trajectories and Adaptive Methods of Children and Adolescents in Child Welfare System.
Assess the prevalence of medico-psychological characteristics at the time of placement (M0), their appearance / disappearance and during the two years following placement (M12 and M24) by age group in children / adolescents in…
- Conditions
- Behavior, Child, Child Development, Child Development Disorder, Adolescent Development
- Trial name
- EvolASE-PEA (NCT05525962)
- Testing
- questionnaries, scales, cognitive tests
- Where
- 5 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Psychotic Disorder
Speech-based Assessment of Relapse Risk in People With Psychosis
This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis.
- Trial name
- TRUSTING-WP4 (NCT07397975)
- Testing
- Weekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.
- Where
- 7 sites in Czechia, Ireland and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Philipp Homan
Methamphetamine Induced Psychosis
Psychiatric Symptom Predictors in Methamphetamine-Induced Psychosis
This longitudinal observational study aimed to investigate environmental, familial, and individual factors associated with psychiatric symptom severity in participants diagnosed with methamphetamine-induced psychotic disorder…
- Trial name
- NCT07459257
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
SCHIZOPHRENIA 1 (Disorder), Psychosocial Adaptation
The Effects of a Solution-Focused Approach on Psychosocial Adjustment and Treatment Compliance in Individuals Diagnosed With Schizophrenia
The aim of this study is to evaluate the effects of a solution-focused approach-based individual intervention on psychosocial adjustment and treatment adherence in individuals diagnosed with schizophrenia.
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Psychosocial Adaptation, Treatment Adherence
- Trial name
- NCT07144592
- Testing
- solution-oriented approach program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Schizophrenia, Cognitive Impairment
From Brain Currents to Interpersonal Flow: Investigating the Social Processing Stream of Schizophrenia
The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia.
- Conditions
- Schizophrenia, Cognitive Impairment, Social Competence
- Trial name
- ecoval (NCT03543553)
- Testing
- This is not an intervention study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Schizoaffective Disorder, Schizophrenia
Obstructive Sleep Apnea Treatment in Serious Mental Illness
Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult
- Trial name
- NCT05457127
- Testing
- Automatic Positive Airway Pressure (APAP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cognitive Impairment, Alzheimer Disease
A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
A study conducted in Finland discovered that a multidomain intervention, consisting of physical activity, nutritional guidance, cognitive training, social activities, and management of vascular risk factors, effectively…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dement
- Trial name
- HERITAGE (NCT05886114)
- Testing
- Structured Multi-domain Intervention, Self-Guided Intervention
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Schizophrenia
The Effect of an Individual Empowerment Program Provided to Relatives of Schizophrenia Patients
Psychoeducation provided to family members caring for individuals with schizophrenia. Has been found to positively impact caregivers' psychological well-being and the effective management of schizophrenia patients.However…
- Trial name
- NCT07173192
- Testing
- Individual empowerment program
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Schizophrenia / Schizoaffective Disorder, SCHIZOPHRENIA 1 (Disorder)
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3
In Study 3, all tasks and models from Aim 1 will be evaluated in a large community sample of online participants recruited through Prolific.
- Conditions
- Schizophrenia / Schizoaffective Disorder, SCHIZOPHRENIA 1 (Disorder), Healthy Adult
- Trial name
- CNTRACS (NCT07900893)
- Testing
- Motion Perception Task, Sine Wave Speech Task, Volatility Task
- Where
- 2 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Auditory Perception
Auditory Localization in Schizophrenia
Auditory sound localization is the ability to identify the position of a sound source in space. It is defined into 3 dimensions: by its position in azimuth, elevation and distance.
- Trial name
- LOCIZ (NCT06974513)
- Testing
- cognitive experiments' session
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Schizophenia Disorder, Bipolar Disorder (BD)
Effects of Schizophrenia and Bipolar Disorder on Exercise Capacity, Pulmonary Function, and Quality of Life
This observational study aims to evaluate exercise capacity, pulmonary function, respiratory muscle strength, and quality of life in individuals diagnosed with schizophrenia and bipolar disorder.
- Trial name
- NCT07306468
- Testing
- Pulmonary Function Test, Respiratory Muscle Strength Evaluation, Quality of Life Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Bipolar Disorder, Schizophrenia
Immuno-Genetic, Inflammation, Retro-Virus, Environment
Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far missing in psychiatry, and to design innovative treatment approaches based on the discovery of new molecular and cellular targets.
- Trial name
- I-Give (NCT02878408)
- Testing
- Blood sampling
- Where
- 6 sites in France
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Pr. Marion Leboyer
Schizophrenia
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights.
- Trial name
- NCT06386588
- Testing
- Closed loop auditory stimulation during sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia
Imaging Synapses With [11C] UCB-J in the Human Brain
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer [11C]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia.
- Trial name
- NCT04038840
- Testing
- [11C]UCB-J radiotracer, PET-MR
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Davidzon, Guido, M.D.
Schizophrenia, Cognitive Impairment
Functional Magnetic Resonance Imaging Study in Schizophrenia Patients and Correlation With Cognitive Impairments
1. Comparison of functional activity at different brain areas related to different cognitive domains e.g. Memory, visuospatial abilities, executive functions, attention, concentration, language, orientation in schizophrenia to…
- Trial name
- NCT06471179
- Testing
- Functional MRI
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Immunoinflammatory State Detection and Multimodal Brain Imaging and Electrophysiologic Changes in Schizophrenia
Schizophrenia is a severe mental illness that seriously affects the health and functioning of patients. Previous studies have found immunoinflammatory abnormalities in the blood, cerebrospinal fluid, central nervous system, and…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Mental Disorders
- Trial name
- SZIM (NCT06673966)
- Testing
- Regular follow-up assessments without intervention., Cross-sectional assessment
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Schizophrenia and Related Disorders, Sleep Disturbance
SPARK Healthy Sleep
SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems.
- Trial name
- SPARK (NCT07119268)
- Testing
- SPARK Healthy Sleep
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Indiana University