Clinical trials: Psychosocial Functioning, open to volunteers
Subjective Cognitive Decline
LLM-Driven Daily Conversation for Cognitive Health in Older Adults
This study will develop and test a daily conversation platform that uses a large language model, a type of artificial intelligence, to support cognitive health in older adults at high risk of dementia.
- Trial name
- LLM-DCI (NCT07751510)
- Testing
- LLM Conversation Cognitive Interaction, Interest-Based Knowledge Reading, Waitlist Health Education
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Retinoblastoma, Neurocognitive Dysfunction
Cognitive Functioning and Health Related Quality of Life in Retinoblastoma Survivors
A retrospective crosssectional observational study of the effects of oncological treatment and frequent general anesthesia on neuropsychological development, psychosocial functioning (in terms of anxiety, depression, peer…
- Conditions
- Retinoblastoma, Neurocognitive Dysfunction, Health-Related Behavior
- Trial name
- RbNeuroQoL (NCT06227962)
- Testing
- Neuropsychological assesment, Psychosocial functioning and quality of life (questionnaires), Parental psychosocial functioning (questionnaires)
- Where
- Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Amsterdam University Medical Center
Chronic Low Back Pain
Virtual Reality-Based Rehabilitation Versus Conventional Therapy in Patients With Chronic Low Back Pain
This study aims to evaluate the effectiveness of rehabilitation using virtual reality compared with conventional physiotherapy in patients with chronic low back pain.
- Trial name
- NCT07463105
- Testing
- Virtual Reality-Assisted Rehabilitation, Conventional Rehabilitation
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- University of Rzeszow
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Chronic Shoulder Pain
Cognitive Functional Therapy Versus Exercises for Chronic Shoulder Pain
The objective of this clinical trial is to determine whether cognitive functional therapy is superior to therapeutic exercises for the treatment of chronic shoulder pain.
- Trial name
- NCT06854809
- Testing
- Cognitive functional therapy, Therapeutic exercise
- Where
- Brazil
- Volunteers
- 148 people
- Sponsor
- Universidade Federal de Sao Carlos
Post Traumatic Stress Disorder PTSD
Psychosocial Factors and Efficacy of Remote Cognitive Remediation for Post-Traumatic Stress Disorder
The goal of this clinical trial is to evaluate whether computer-based brain training can help adults with post-traumatic stress disorder (PTSD).
- Trial name
- NCT07309302
- Testing
- Cognitive Remediation Training, Control Group
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Université du Québec a Montréal
Depression, Stress Disorders, Post-Traumatic
Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy.
- Trial name
- NCT07202325
- Testing
- Resilience Training for Veterans (REST-V), Usual resources
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Stress (Psychology), Inflamation
A Mindfulness-Based Intervention to Reduce Stress Through the Cultivation of Loving-Kindness, Compassion, Joy, and Equanimity in Healthcare Professionals
Nearly 50% of the adult workforce experience adverse psychological symptoms (e.g., stress, depression, burnout, etc.) stemming from workplace stressors, with healthcare workers experiencing rates as high as 80%.
- Conditions
- Stress (Psychology), Inflamation, Psychosocial Functioning
- Trial name
- FIERCE (NCT07283744)
- Testing
- Building Emotional Strength Training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Prostate Cancer (Adenocarcinoma), Radical Prostatectomy
Evaluation of Pelvic Floor Function and Psychosocial Sequelae Following Radical Prostatectomy for Prostate Cancer
This observational cross-sectional study aims to evaluate the effects of radical prostatectomy for prostate cancer on pelvic floor function and psychosocial well-being.
- Conditions
- Prostate Cancer (Adenocarcinoma), Radical Prostatectomy, Urinary Incontinence (UI), Erectile Dysfunction Following Radical Prostatectomy
- Trial name
- NCT07693647
- Testing
- No Interventions
- Where
- Spain
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Stroke, Post-stroke Depression
Physical Capacity Building for Chronic Stroke
Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery.
- Trial name
- NCT07039305
- Testing
- Physical capacity training for chronic stroke - building aerobic capacity and muscle strength
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Stroke
Weight Loss and ExeRcise for Post-stroke Veterans
Weight loss interventions for neurologically health individuals have established benefits for improving physical and psychosocial function.
- Trial name
- EMPOWER (NCT06322030)
- Testing
- FOCUS-15 Lifestyle Management Program, Exercise Training
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- VA Office of Research and Development
Severe Mental Illness, Schizophrenia
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study evaluates a group-based intervention designed to improve romantic and social relationship skills in adults living with a severe mental illness (SMI), such as schizophrenia, bipolar disorder, or major depressive…
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- A2C'estMieuxVE (NCT07316803)
- Testing
- À deux, c'est mieux (Better Together) Group Intervention
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Functional Independence
Behavioral Activation for Independence in Older Veterans
As Veterans age, chronic health conditions increase their risk of functional limitations, or difficulty completing day-to-day activities independently.
- Trial name
- ACTIVaTE (NCT05493241)
- Testing
- Behavioral Activation for Independence in Older Veterans (ACTIVaTE), Usual care
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Amenorrhea Secondary
Effects of Physical and Psychosocial Stress on Functional Hypothalamic Amenorrhea in Exercising Women
The goal of this clinical trial is to determine how changes in exercise and psychosocial stress may influence the risk of menstrual cycle irregularities in female runners and cyclists.
- Trial name
- FHA (NCT05967819)
- Testing
- Exercise Stress, Psychosocial Stress
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Schizophrenia, Schizo Affective Disorder
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT07006935
- Testing
- Clubhouse Model of Psychosocial Rehabilitation for Serious Mental Illness, Usual Community-Based Mental Health Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Western Reserve University
Neck Pain, Patient Education
Effects of Education and Exercise on Pain, Psychosocial Factors, and Upper Limb Function in Non-specific Neck Pain.
Pain neuroscience education is currently one of the techniques being explored in physiotherapy for pain management. The benefits of this technique are gradually becoming evident in various published studies.
- Conditions
- Neck Pain, Patient Education, Exercise Therapy, Fear
- Trial name
- PNE-EXNP (NCT06889389)
- Testing
- Education, Excercise
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Suicide, Attempted, Functioning, Psychosocial
iFD-SuRvivE funCtiONal effiCacy and bIologicaL corrElates (RECONCILE Study)
The goal of this clinical trial is to assess the effectiveness of an original intervention 'Functional Recovery in Depression and Suicide Risk Prevention Based on Emotion Regulation and Values: A Group Program' (from the original…
- Conditions
- Suicide, Attempted, Functioning, Psychosocial, Cognition, Neuroimaging
- Trial name
- RECONCILE (NCT05655390)
- Testing
- 'Functional Recovery in Depression and Suicide Risk Prevention Based on Emotion Regulation and Values: A Group Program'
- Where
- 4 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Iria Grande
Childhood Cancer, Siblings
Siblings to a Child With Cancer: Needs and Pre-loss Grief
Background and Aim: Siblings to a brother or sister with cancer have reported difficulties dealing with such things as their parents' suffering, loneliness in relation to their own feelings as well as uncertainty regarding their…
- Conditions
- Childhood Cancer, Siblings, Psychosocial Functioning
- Trial name
- NCT06854822
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Ersta Sköndal University College
Adolescent Behavior, Adolescent - Emotional Problem
Teachers Leading the Front Lines - Adolescent
Purpose: The purpose of this research is to pilot test a novel, alternative, potentially sustainable system of teacher-delivered, task-shifted adolescent mental health care.
- Conditions
- Adolescent Behavior, Adolescent - Emotional Problem, Mental Health Issue, Psychosocial Functioning
- Trial name
- TeaLeaf-A (NCT06248203)
- Testing
- Tealeaf-Mansik Swasta (Tealeaf) as adapted for Adolescents, Enhanced Usual Care (EUC)
- Where
- India
- Volunteers
- 216 people
- Sponsor
- University of North Carolina, Chapel Hill
Mild Cognitive Impairment (MCI), Sarcopenia
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance.
- Trial name
- NCT06828926
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio University