Clinical trials: Psychotic Disorder
Bipolar Disorder, Schizoaffective Disorder
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study.
- Conditions
- Bipolar Disorder, Schizoaffective Disorder, Manic Disorder, Mania
- Trial name
- NCT00431184
- Testing
- Pentazocine, Lorazepam
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mclean Hospital
Schizophrenia, Psychosis
RCT Examining the Effectiveness of Digital Picture Frame Use in Inpatient Setting
This study will be a randomized controlled trial that investigates the effectiveness of digital picture frames (DPF) installed in inpatient rooms on long stay inpatient wards servicing schizophrenia clients at CAMH.
- Conditions
- Schizophrenia, Psychosis, Psychosis NOS
- Trial name
- NCT02950571
- Testing
- Digital Picture Frame, Standard Care
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Centre for Addiction and Mental Health
Severe Mental Illness, Schizophrenia
The Potential Efficacy of the Chinese Health Improvement Profile- A Pilot Clustered Randomised Controlled Trial
The investigators programme of research will evaluate an existing physical health care screening intervention with the aim of helping Community Psychiatric Nurses (CPN) to improve the physical health wellbeing of people with a…
- Conditions
- Severe Mental Illness, Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- CHIP (NCT02453217)
- Testing
- Chinese CHIP, Treatment as usual
- Volunteers
- 144 people
- Sponsor
- Wai-Tong Chien
Parkinson's Disease
A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease
The major purpose of the Stage 1 is to study the safety and tolerability of the proposed dosage regimen of the study drug. The form of cannabidiol (CBD) used in this study is GWP42003, supplied by GW Pharmaceuticals.
- Trial name
- NCT02818777
- Testing
- cannabidiol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Schizophrenia and Disorders With Psychotic Feature, Psychotic Episode
Mindfulness-based Social Cognition Training for Psychosis (SocialMind): A Feasibility Study
The current investigation has been designed to test the feasibility of a mindfulness-based social cognition training (SocialMind) for people with a first episode of psychosis (AGES-Mind Study, NCT03309475).
- Trial name
- NCT03434405
- Testing
- SocialMind, Psychosocial treatment, Psychotropic treatment
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Mental Health, Psychotic Disorders
Monitoring and Management for Metabolic Side Effects of Antipsychotics
The purpose of this study is to test an approach for implementing guideline recommendations for assessing and managing metabolic side effects (including weight gain, diabetes, elevated lipids) in patients prescribed antipsychotic…
- Trial name
- AMMP (NCT01875861)
- Testing
- Evidence-Based Quality Improvement Plus Facilitation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Schizoaffective Disorder
Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia
The investigators intend to explore the hypothesis that symptoms of schizophrenia may be reduced by the administration of a probiotic supplement when used in addition to standard antipsychotic medications.
- Trial name
- NCT01242371
- Testing
- Probiotic Supplement
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Sheppard Pratt Health System
Schizophrenia Spectrum
Target Engagement for Oxytocin: Dose Ranging Study
This study will evaluate the effect of 8 doses of intranasal oxytocin or placebo on two proposed measures of target engagement in brain.
- Trial name
- R21Dose (NCT02498236)
- Testing
- Intranasal Oxytocin
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Schizophrenia
A Double-Blind Trial of Adjunctive Valacyclovir to Improve Cognition in Early Phase Schizophrenia
The primary aim of the study is to determine the efficacy of adjunctive valacyclovir, in comparison to placebo, to improve visual (Brief Visuospatial Memory Test) and working (composite score of the Spatial Span and Letter Number…
- Trial name
- VISTA (NCT02008773)
- Testing
- Valacyclovir HCI 500 mg tablets
- Where
- 13 sites in United States
- Volunteers
- 170 people
- Sponsor
- Indiana University
Schizophrenia, Psychotic Disorders
The Role of Personal Identity in Psychotic Symptoms: a Study With the Repertory Grid Technique
Personal identity is being recently recognized as a core element for mental health disorders, with relevant clinical implications. However, scarcity of data exists on its role in schizophrenia and related disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Self
- Trial name
- NCT03820362
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- University of Barcelona
Schizophrenia, Schizoaffective Disorder
Efficacy and Tolerability Study of Betahistine to Ameliorate Antipsychotic Associated Weight Gain
The study attempts to evaluate a histamine analog long used for the treatment of Meniere's disease, betahistine, that shows promise in reversing the antihistaminergic effects thought to be involved in antipsychotic induced weight…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar I Disorder
- Trial name
- NCT00709202
- Testing
- Betahistine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Schizophrenia, Psychosis
Glutamate, Brain Connectivity and Duration of Untreated Psychosis
The early stages of schizophrenia are associated with significant decreases in social and intellectual abilities, with more declines in chronic disease.
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder
- Trial name
- DUP (NCT02034253)
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Schizophrenia, Schizoaffective Disorder
Clinical Trial of AVL-3288 in Schizophrenia Patients
Single-center, outpatient, randomized, double-blind, placebo-controlled, 3-treatment-phase, cross-over study to evaluate the safety, tolerability and efficacy of two oral doses of AVL-3288 each compared to placebo, in patients…
- Trial name
- NCT02978599
- Testing
- AVL-3288
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- New York State Psychiatric Institute
Smoking Cessation, Schizophrenia
Examining Persistence in Smokers With Schizophrenia
All participants will receive free weekly counseling (8- weeks) and free nicotine patches (10-weeks). They will complete assessment measures commonly used in smoking cessation studies.
- Conditions
- Smoking Cessation, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT03346291
- Testing
- counseling
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rutgers, The State University of New Jersey
Schizophrenia, Schizoaffective Disorder
Neurophysiological Studies in Schizophrenia and Psychiatric Disorders
The overall goal of this project is to identify intermediate phenotypes for psychosis across the schizophrenia and bipolar disorders boundary with implications for future genetic studies.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- BSNIP (NCT01384604)
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Psychosis, Schizophrenia
ReMindCare App for Patients From First Episode of Psychosis Unit.
ReMindCare is an app designed by the Unit of Psychiatry at the Clinical Hospital of Valencia in liaison with the Polytechnic University of Valencia.
- Conditions
- Psychosis, Schizophrenia, Psychotic Disorders, Delirium
- Trial name
- NCT03807388
- Testing
- ReMindCare Intervention Group, Treatment as Usual
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Instituto de Investigacion Sanitaria INCLIVA
Schizophrenia and Related Disorders, Psychotic Disorders
Exercise and Overnight Motor Sequence Task
The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the…
- Trial name
- EOMST (NCT03800368)
- Testing
- Exercise, Non-exercise
- Volunteers
- 51 people
- Sponsor
- The University of Hong Kong
Alcohol Dependence, Bipolar Disorder
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
The study will determine if individuals with co-occurring bipolar disorder and alcohol dependence report reduced alcohol consumption, improvement in mood symptoms, and cognitive performance if treated with lamotrigine plus their…
- Conditions
- Alcohol Dependence, Bipolar Disorder, Depression, Mania
- Trial name
- NCT01015586
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
Schizophrenia
Effectiveness of Neuroadaptive Cognitive Training in Adolescents at Risk for Psychosis
This study will evaluate the effectiveness of intensive computerized cognitive training in preventing the onset of psychotic disorder and improving adaptive functioning in adolescents at high risk of schizophrenia.
- Trial name
- NCT00655239
- Testing
- Neuroadaptive cognitive training, Computer games
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bipolar Disorder, Schizoaffective Disorder
Probiotics to Prevent Relapse After Hospitalization for Mania
The purpose of this study is to determine if taking a probiotic supplement versus a placebo will lower rates of relapse and improve the clinical course among participants who have been hospitalized for mania.
- Trial name
- NCT01731171
- Testing
- Probiotic Supplement, Inert Compound
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Sheppard Pratt Health System