Clinical trials: Psychotic Disorder
SCHIZOPHRENIA 1 (Disorder), Metabolic Abnormalities
Efficacy of Pediococcus Acidilactici as add-on to Antipsychotic Drugs on Metabolic Syndrome Disturbances in First-episode Psychosis and Schizophrenia Spectrum Disorders.
The aim of the present study is to evaluate the effectiveness of the addition of the postbiotic Pediococcus acidilactici (pA1c®HI) on amelioration of metabolic disturbances in patients with (FEP) or (SSD) treated with…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Metabolic Abnormalities, Postbiotic Supplement
- Trial name
- GLUCOPSICO (NCT07371325)
- Testing
- Pediococcus acidilactici, pA1c®HI postbiotic supplementation taking participants, Atypical antipsychotics (AAP)
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Manuel Jesús Cuesta Zurita
Schizophrenia, Stigma, Social
Effectiveness of A Stigma Directed Interventional Program in Schizophrenia
randomized controlled study measuring the effectiveness of Stigma focused intervention in patients suffering from Schizophrenia
- Trial name
- NCT03930225
- Testing
- Stigma Directed Psycho-educational Intervention program
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Schizophrenia
Planning Your Everyday Life in Virtual Reality : a Study in Schizophrenia;
Patients with schizophrenia , who visit frenquently day-care or day-care activities clinics, often experience difficulties of daily living and cognitive deficits. Living independently is a key for recovery.
- Trial name
- PlaniRev (NCT04011774)
- Testing
- PLANI-REV, RELAXATION
- Where
- 4 sites in France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia
A Study of Brenipatide in Adult Participants With Schizophrenia
The purpose of this study is to assess the efficacy and safety of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC for treatment of schizophrenia.
- Trial name
- RENEW-Scz-1 (NCT07410507)
- Testing
- Brenipatide
- Where
- 101 sites in United States, Argentina and 5 more
- Volunteers
- 450 people
- Sponsor
- Eli Lilly and Company
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Schizophrenia
A Phase III Study of SM-13496 (Lurasidone HCl) in Patients With Schizophrenia
The study evaluates the efficacy and safety of SM-13496 compared with placebo in patients with schizophrenia.
- Trial name
- NCT01614899
- Testing
- SM-13496 40mg, SM-13496 80mg
- Where
- 4 sites in Japan, Malaysia and 2 more
- Volunteers
- 457 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Schizophrenia
Evaluate the Pharmacokinetics of Quetiapine Fumarate in Chinese Schizophrenic Patients
The primary objective of the study is to evaluate the pharmacokinetics of XR quetiapine fumarate(300mg,600mg,and 800mg once-daily) in Chinese schizophrenic patients .
- Trial name
- NCT00919607
- Testing
- quetiapine fumarate extended-release
- Where
- China
- Volunteers
- 31 people
- Sponsor
- AstraZeneca
Schizophrenia, Schizoaffective Disorder
Clinical Trial of AVL-3288 in Schizophrenia Patients
Single-center, outpatient, randomized, double-blind, placebo-controlled, 3-treatment-phase, cross-over study to evaluate the safety, tolerability and efficacy of two oral doses of AVL-3288 each compared to placebo, in patients…
- Trial name
- NCT02978599
- Testing
- AVL-3288
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- New York State Psychiatric Institute
Psychosis
A Probiotic Strategy for Antipsychotic-induced Metabolic Dysfunction
Antipsychotic drugs are used to treat a range of psychiatric disorders including schizophrenia, bipolar disorders, and psychotic depression.
- Trial name
- MetaboMicrobe (NCT06729671)
- Testing
- Bifidobacterium longum APC1472 hydroxypropylmethylcellulose (HPMC) capsule, maltodextrin
- Where
- 2 sites in Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork
Schizophrenia
The Effect of Developing Psychological Resilience on Functionality in Schizophrenia Patients
People with schizophrenia have low functionality and psychological resilience. Psychological resilience of individuals can be improved. The funcionality of individual with improved psychological resilience can also be improved.
- Trial name
- NCT05739344
- Testing
- Cognitive behavioral approach based resilience development program for schizophrenic individuals
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Schizophrenia, Auditory Hallucinations
Transcranial Direct Current Stimulation (tDCS) and Hallucinations in Schizophrenia
The purpose of this study is to determine whether trans Direct Current Stimulation (tDCS) is effective in the treatment of auditory hallucinations in schizophrenia.
- Trial name
- NCT00870909
- Testing
- active tDCS
- Where
- 2 sites in France, Tunisia
- Volunteers
- 46 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia, Schizoaffective Disorder
Body Mass Index (BMI) and Metabolic Changes Following Switch to Aripiprazole From Olanzapine, Risperidone and Quetiapine
Weight gain is a serious, common side effect of many antipsychotic medications. On average, the highest amounts of weight gain are found to occur in people taking clozaril and olanzapine, but with significant weight gain occuring…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Mood Disorders
- Trial name
- NCT00312598
- Testing
- Aripiprazole
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia
A 2-year Study of Patients With Schizophrenia Who Are Treated With Long-acting Injectable Risperidone.
The purpose of this study is to examine treatment practices of adult schizophrenia patients by their own doctors, and to assess patient outcomes when treated with long-acting risperidone injection over a two-year period of…
- Trial name
- NCT00261430
- Testing
- GAIN Acceptance Approach
- Volunteers
- 650 people
- Sponsor
- Janssen, LP
Substance Abuse, Criminal Behavior
Feasibility of Mobile and Technology Assisted Aftercare Services for Crisis Stabilization Units
In this study investigators are examining the feasibility and acceptability of an expanded and technology-assisted aftercare program with persons released from a crisis stabilization unit (CSU) who were brought to the CSU by…
- Conditions
- Substance Abuse, Criminal Behavior, Mental Disorder
- Trial name
- NCT04899934
- Testing
- mobile and technology assisted aftercare, Treatment as usual
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Florida State University
Healthy, Mental Disorder
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers
Abnormalities in the re-uptake of dopamine and serotonin have been described in various neuropsychiatric disorders and substance abuse.
- Conditions
- Healthy, Mental Disorder, Obsessive Compulsive Disorder, Schizophrenia
- Trial name
- NCT00001771
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Relapse Management
Relapse Management Group Psychoeducation Program
This study was planned to be conducted between February and March 2026, with a total of 60 patients diagnosed with schizophrenia who met the inclusion criteria and were followed at the community mental health center in the…
- Trial name
- NCT07327944
- Testing
- Relapse Management Group Psychoeducation Program
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Behavior Problem, Mental Disorder
FCT Study: Reducing the Need for Out-of-Home Placements
Does Family Centered Treatment (FCT) result in better youth, family, and cost outcomes, as compared to a Level II or Level III out-of-home placement (OHP)? The investigators test the hypotheses that among children/youth…
- Conditions
- Behavior Problem, Mental Disorder, Emotional Problem
- Trial name
- 2018-0568 (NCT03641664)
- Testing
- Family Centered Treatment, Level II or Level III Out of Home Placement
- Where
- 2 sites in United States
- Volunteers
- 750 people
- Sponsor
- Duke University
Schizophrenia
Comparative Bioavailability Study of Aripiprazole 10 mg Oral Soluble Film vs Abilify® 10 mg Tablet in Healthy Volunteers
The purpose of this study is to compare the rate and extent of absorption of Aripiprazole Oral Soluble Film 10 mg (Test) versus Abilify® 10 mg tablet (Reference) in healthy male volunteers
- Trial name
- NCT02501109
- Testing
- Aripiprazole
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- CMG Pharmaceutical Co. Ltd
Mental Illness Persistent, Cardiovascular Prevention
Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness
The goal of this prospective, randomized trial is to explore the link between cardiovascular disease and mortality in individuals with severe and persistent mental illness (SPMI).
- Trial name
- NCT05659498
- Testing
- Cardiac Rehabilitation Program
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Effectiveness of a Problem-solving Intervention for Common Adolescent Mental Health Problems in India
We will conduct a two-arm individually randomized controlled trial in six Government-run secondary schools in New Delhi. The targeted sample is 240 adolescents in grades 9-12 with persistent, elevated mental health difficulties…
- Trial name
- PRIDE (NCT03630471)
- Testing
- PRIDE 'Step 1' problem-solving intervention, Enhanced usual care
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Sangath