Clinical trials: Psychotic Symptoms
Schizophrenia, Insight Impaired
The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schizophrenia
The study aimed to investigate the effects of bimodal anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) on psychopathological symptoms, insight, psychosocial functioning…
- Conditions
- Schizophrenia, Insight Impaired, Psychotic Symptoms, Schizoaffective Disorder
- Trial name
- NCT03701100
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Auditory Hallucination, Verbal
Effects of Transcranial Direct Current Stimulation (tDCS) on Persistent Auditory Verbal Hallucinations in Schizophrenia
Many individuals with schizophrenia struggle with auditory verbal hallucinations (AVHs). In some cases, these AVHs can be resistant to medication treatment.
- Trial name
- NCT04222582
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Schizophrenia
Efficacy of Metacognitive Training for Schizophrenia - a Study Protocol
Metacognitive training (MCT) for schizophrenia has been used in several countries, but its efficacy remains unclear. MCT is a program group that consists of changing the cognitive infrastructure of delusions.
- Trial name
- NCT03891186
- Testing
- Metacognitive Training in Schizophrenia (MCT), Treatment As Usual (TAU)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University Rovira i Virgili
Schizophrenia
Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia
The purpose of this study is to investigate the effects of flexibly dosed Brexpiprazole monotherapy in the improvement of early-episode schizophrenia through the assessment of social functioning, efficacy, and tolerability.
- Trial name
- NCT02013622
- Testing
- Brexpiprazole
- Where
- 22 sites in United States
- Volunteers
- 49 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Mental Disorders
Evaluation of an Intervention to Promote Physical Activity in Outpatients With Mental Disorders
The purpose of this study is to determine if a manualised intervention to promote physical activity (MoVo-LISA) is effective to help psychiatric outpatients to increase their level of everyday physical activity.
- Trial name
- GAF (NCT02569619)
- Testing
- Activity Intervention, Healthy Diet Intervention
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Charite University, Berlin, Germany
Depression, Schizophrenia
Repetitive Transcranial Magnetic Stimulation (rTMS) and P50 Evoked Potential Component
The repetitive transcranial magnetic stimulation (rTMS) is a recent technique that has demonstrated its efficiency in both depression and schizophrenia.
- Trial name
- rTMS-P50 (NCT01466439)
- Testing
- high-frequency of repetitive transcranial magnetic stimulation (rTMS), low frequency of repetitive transcranial magnetic stimulation (rTMS)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
HIV Infections, Central Nervous System Diseases
Central Nervous System Disease in HIV-infected Children on HAART
This study will examine how HIV affects the brain and nervous system, learning, and behavior in children on highly active antiretroviral therapy (HAART).
- Trial name
- NCT00110331
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Alcoholism, Alcohol Drinking
Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for…
- Conditions
- Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders
- Trial name
- NCT04934553
- Testing
- Amplification of Positivity Training, Cognitive-behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Charles Taylor
Schizophrenia
Modafinil Augmentation in Chronic Schizophrenia and Schizoaffective Disorder
This is an open label 8-week trial of modafinil up to 400 mg daily added to a stable antipsychotic regimen to evaluate the effect modafinil on cognition, sedation, and weight in patients with chronic schizophrenia.
- Trial name
- NCT00838227
- Testing
- modafinil
- Sponsor
- Manhattan Psychiatric Center
Agitation
Naturalistic Adasuve Clinical Trial Study
There is limited information on the best psychoactive medication to treat agitated patients in the emergency department. The intent of this study is to fill in knowledge gaps in the current practice of treating psychiatric…
- Trial name
- NCT02877108
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mt Sinai Hospital, Chicago
Negative Type; Schizophrenic, Anhedonia
Motive-specific Intervention for Negative Symptoms in Schizophrenia
The aim of this study is to test a therapeutic intervention to reduce negative symptomatic among schizophrenia patients. Since the intervention can take place within an inpatient stay, it is a short intervention.
- Conditions
- Negative Type; Schizophrenic, Anhedonia, Apathy
- Trial name
- MoNSS (NCT04793438)
- Testing
- Motive-specific intervention, Supportive conversations
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Schizophrenia
Treating Refractory Schizophrenia With rTMS
Symptomatic treatment of the negative symptoms in schizophrenia (such as social withdrawal, affective flattening, poor motivation, and apathy) with medications and psychotherapy are almost non-existent, whereas treatment of the…
- Trial name
- NCT02242578
- Testing
- 1 Hz rTMS, 10 Hz rTMS
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Seton Healthcare Family
Schizophrenia
Repetitive Transcranial Magnetic Stimulation for the Treatment of Negative Symptoms in Schizophrenia Patients.
This study is to determine whether high frequency repetitive transcranial magnetic stimulation (rTMS) is effective in the treatment of negative symptoms in schizophrenia patients
- Trial name
- NCT02842034
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Hallucinations
Evaluation of Internet-based Cognitive Behavioral Self-help Treatments for People With Psychosis
Schizophrenia is a severe mental disorder which is accompanied by an enormous individual and societal burden. Despite established efficacy of cognitive behavioral therapy for psychosis (CBTp), its dissemination into routine…
- Conditions
- Schizophrenia, Hallucinations, Persecutory Delusion
- Trial name
- EviBaS (NCT02974400)
- Testing
- Internet-based, CBT-oriented, guided self-help
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 101 people
- Sponsor
- University of Bern
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures, Third Wave
The CLIMATE-III Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-III (NCT06890208)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 176 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Schizophrenia, Central Obesity
Acupuncture Treatment for Schizophrenia-related Central Obesity
This clinical trial aims to test the effect of acupuncture in patients with schizophrenia-related central obesity. The main question it aims to answer is: The effect, safety, and maintenance of acupuncture on…
- Trial name
- NCT05833009
- Testing
- Acupuncture
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Shanghai Mental Health Center
Obesity
Anti-psychotic Medication (Stable Dose) Weight Loss Study
This is a pilot study to determine the safety and efficacy of an investigational product (IHBG-10) on weight change and changes in body composition in subjects who have been taking a stable dose of certain anti-psychotic…
- Trial name
- NCT01272765
- Testing
- IHBG-10
- Where
- United States
- Sponsor
- Avera McKennan Hospital & University Health Center
Borderline Personality Disorder
Verkes Borderline Study: The Effect of Quetiapine on Borderline Personality Disordered Patients
In patients with schizophrenia, 'atypical' antipsychotics such as clozapine may be effective in the treatment of psychosis. In patients with borderline personality disorder (BPD), as far as the investigators know, no well…
- Trial name
- NCT00254748
- Testing
- Quetiapine fumarate
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
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