Clinical trials: Psychotic Symptoms
Schizophrenia, Negative Symptoms in Schizophrenia
Optimal rTMS for Cognitive Deficits and Negative Symptoms in Schizophrenia
Negative symptoms and cognition decline are major challenges in clinical management of schizophrenia. Dorsomedial prefrontal cortex (DLPFC) has been highly involved in the mechanisms of negative symptoms and cognitive symptoms of…
- Conditions
- Schizophrenia, Negative Symptoms in Schizophrenia, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation
- Trial name
- NCT05599373
- Testing
- Bilateral Active Repetitive transcranial magnetic stimulation (rTMS), Left Active Repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Mental Health Center
Relapse Rates Related to Website Usage
Web-based Support for People With Schizophrenia and Their Families
This study will assess the feasibility of using the internet and in-home computers to provide advice from health care professionals, social support, and health information to people with schizophrenia and their families.
- Trial name
- NCT00177983
- Testing
- (relapse rate)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bipolar Disorder, Schizo Affective Disorder
Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation
Mania is a core symptom of bipolar disorder involving periods of euphoria. Decreased inhibitory control, increased risk-taking behaviors, and aberrant reward processing are some of the more recognized symptoms of bipolar disorder…
- Trial name
- NCT05445466
- Testing
- High-Definition Transcranial Electrical-Current Stimulation, High-Definition Transcranial Alternate-Current Stimulation, High-Definition Personalized Beta-Gamma Electrical Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Disorder, Anxiety
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
The purpose of this study is to investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in subjects with major depressive disorder and anxiety symptoms, who are experiencing an inadequate…
- Trial name
- NCT02013531
- Testing
- Brexpiprazole
- Where
- 21 sites in United States
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Obesity
Proper Nutrition, Physical Exercise and Appropriate Weight in Individuals With Long Term Mental Illness
Based on previous findings that mentally ill inpatients are interested in losing treatment associate weight gain and are capable of adhering to a weight reduction program, this study will investigate the effects of participation…
- Trial name
- NCT00474227
- Testing
- group therapy, physical exercise, nutrition lectures
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Lev-Hasharon Mental Healtlh Center
Schizophrenia, Psychotic Disorders
Effect of Curcumin Add-On Therapy on Quality of Life and IL-1β Levels in Patients With Schizophrenia
This study aims to evaluate the effect of curcumin extract as an adjuvant therapy on quality of life and inflammatory markers in patients with schizophrenia receiving risperidone.
- Trial name
- CUR-SCZ (NCT07523256)
- Testing
- Curcumin, Risperidone 4mg/day
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Rinvil Renaldi
Schizophrenia, Schizoaffective Disorder
Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia
The investigators intend to explore the hypothesis that symptoms of schizophrenia may be reduced by the administration of a probiotic supplement when used in addition to standard antipsychotic medications.
- Trial name
- NCT01242371
- Testing
- Probiotic Supplement
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Sheppard Pratt Health System
Schizophrenia, Apathy
Apathy in Schizophrenia
Apathy, defined as a quantitative reduction of voluntary, goal-directed behaviours (GDB), is a core component of negative symptoms.
- Trial name
- NCT01689181
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression
Step Away From Depression - Evaluation of a Pedometer Intervention With Inpatients With Major Depression
The purpose of this study is to determine if the use of pedometers can help depressive inpatients in psychiatric clinics to increase their level of physical activity.
- Trial name
- SAD (NCT02850341)
- Testing
- Pedometer
- Where
- 9 sites in Austria, Germany
- Volunteers
- 292 people
- Sponsor
- Charite University, Berlin, Germany
Obesity, Vitamin D Deficiency
Vitamin D Supplementation in Psychiatric Illnesses
Children and adolescents with psychiatric illnesses who are treated with medications called second generation antipsychotic agents (SGA) often gain excessive weight during their treatment with these medications.
- Conditions
- Obesity, Vitamin D Deficiency, Psychosis, Schizophrenia
- Trial name
- VDSS (NCT01004354)
- Testing
- Ergocalciferols
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Massachusetts, Worcester
Psychosis
Culturally Adapted Cognitive Behavior Therapy for Psychosis in Pakistan
Aim: To assess the feasibility of application of culturally-adapted CBT (CaCBTp) for use in Pakistan. Design: Randomized Control Trial Setting: Psychiatry Departments of General Hospitals in Karachi.
- Trial name
- NCT02202694
- Testing
- Culturally Adapted Cognitive behavior therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Pakistan Institute of Living and Learning
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Schizophenia Disorder
Theta- and Alpha-Tuned Meditation for Negative Symptoms in Schizophrenia
This study done at the psychiatrics hospital of the cross Lebanon examined whether guided meditation combined with special sound stimulation (binaural beats) could help reduce negative symptoms of schizophrenia, such as low…
- Trial name
- ALPHATH-SCZ (NCT07437365)
- Testing
- Alpha binaural beats, Theta binaural beats
- Where
- Lebanon
- Volunteers
- 90 people
- Sponsor
- Psychiatric Hospital of the Cross
Schizophrenia, Latent, Negative Symptoms in Schizophrenia
Effectiveness of Behavioral Activation Treatment for Schizophrenia
The purpose of this study is to implement a behavior activation remote program for negative symptoms of schizophrenia and to verify whether the behavior activation remote program for negative symptoms of schizophrenia has effects…
- Conditions
- Schizophrenia, Latent, Negative Symptoms in Schizophrenia, Behavioral Activation, Remote Medical Service
- Trial name
- NCT05764148
- Testing
- behavioral activation
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Inha University Hospital
Schizophrenia, Antipsychotic Drug
Xingqi Daozhi Decoction for Antipsychotic-Induced Constipation
Antipsychotic medications are widely used to treat schizophrenia but may cause constipation, which can lead to abdominal discomfort, reduced quality of life, and poor treatment adherence.
- Trial name
- XQD-AIC (NCT07767526)
- Testing
- Xingqi Daozhi Decoction
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Adjunctive Selective Estrogen Receptor Modulators on Negative and Cognitive Symptoms of Schizophrenia in Women
The aim of the project is to assess the efficacy of Adjunctive Selective Estrogen Receptor Modulators (Raloxifene) on Negative and Cognitive symptoms of Schizophrenia in Postmenopausal Women.
- Trial name
- NCT03418831
- Testing
- Raloxifene Hydrochloride
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Effects of Low-dose Levetiracetam on Clinical Symptoms, Cognition and Hippocampal Hyperactivity in Schizophrenia
Levetiracetam (LEV: (S)-α-ethyl-2-oxo-pyrrolidine acetamide) is an anticonvulsant/antiepileptic drug. The specific aim of this study is to assess the efficacy of low-dose LEV in reducing hippocampal activity in schizophrenia.
- Trial name
- NCT02647437
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Schizophrenia
Repetitive Transcranial Magnetic Stimulation for "Voices"
OBJECTIVES: I. Determine the effect of repetitive transcranial magnetic stimulation on treatment refractory auditory hallucinations of patients with schizophrenia.
- Trial name
- NCT00004980
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Schizophrenia
Anti-inflammatories and Adolescent Schizophrenia
A double-blind controlled trial assessing the efficacy of anti-inflammatories on symptoms and cognition of adolescents with schizophrenia
- Trial name
- NCT04020588
- Testing
- Celecoxib 200mg, Minocycline 100mg
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico
Apathy, Schizophrenia
Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms.
This study is looking to determine if Lumateperone improves motivation in patients with schizophrenia or schizoaffective disorders who show high levels of apathy as judged by AES-C-Apathy (Apathy Evaluation Scale - Clinician …
- Conditions
- Apathy, Schizophrenia, Schizophrenia; Psychosis
- Trial name
- NCT06482554
- Testing
- Lumateperone 42 mg, Risperidone 2 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
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