Clinical trials: Psychotic Symptoms
Alzheimer Disease, Psychotic Disorders
Antipsychotic Discontinuation in Alzheimer's Disease
In patients with Alzheimer's disease (AD) who respond to antipsychotic treatment of psychosis and/or agitation/aggression, the relapse risk after discontinuation is not established.
- Conditions
- Alzheimer Disease, Psychotic Disorders, Agitation, Aggression
- Trial name
- ADAD (NCT00417482)
- Testing
- risperidone
- Where
- 7 sites in United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Psychosis, Schizophrenia
Virtual Reality Avatar Therapy for People Hearing Voices
Hearing voices is probably the worst form of acoustic hallucinations; which can be experienced as severely disturbing and is influenced by diverse factors including the ability of the individual to influence and control the…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Hearing Voices When No One is Talking (Symptom)
- Trial name
- NCT04099940
- Testing
- Virtual Reality Avatar Therapy (VRAT), Assertiveness Training Program (ATP)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Psychiatric University Hospital, Zurich
Schizophrenia, Schizoaffective Disorder
Adjunctive Treatment for Decreasing Symptoms of Schizophrenia
This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patients with schizophrenia.
- Trial name
- NCT00222235
- Testing
- d-cycloserine, glycine
- Where
- 5 sites in United States, Israel
- Volunteers
- 240 people
- Sponsor
- University of Maryland, Baltimore
Major Depression With Psychotic Features
Treatment of Major Depressive Disorder With Psychotic Features.
The purpose of this study is to determine the safety and efficacy of risperidone monotherapy in the treatment of psychotic depression.
- Trial name
- NCT00174590
- Testing
- risperidone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Schizoaffective Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation in the Prevention of Relapse of Schizoaffective
The purpose of this study is to evaluate the efficacy of repetitive transcranial magnetic stimulation in the prevention of relapse of the symptoms of schizoaffective disorder.
- Trial name
- NCT02221635
- Testing
- rTMS + risperidone, Risperidone
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Xijing Hospital
Schizophrenia, Cognitive and Executive Dysfunction
A Pilot Study of Adjunctive Structured Supportive Psychotherapy in Schizophrenia
This pilot randomized controlled trial examined whether adding structured supportive psychotherapy to risperidone treatment is more effective than risperidone alone in improving cognitive function and reducing peripheral…
- Conditions
- Schizophrenia, Cognitive and Executive Dysfunction, Neuroinflammation
- Trial name
- PILOT-SSP-SCZ (NCT07671040)
- Testing
- Structured supportive psychotherapy, Risperidone, Unstructured Supportive Conversation
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Hasanuddin University
Cardiovascular Diseases, Mental Disorder
A Phone-call With a Student/General Practitioner Team to Impact Morbidity of Chronic Patients During COVID-19 Containment
Following the announcement of the containment of the population due to the COVID-19 epidemic on March 17, 2020 in France, a notable decrease in the number of consultations in general practice was reported.
- Trial name
- COVIQuest (NCT04359875)
- Testing
- Phone-call screening and management by a medical student/general practitioner tandem
- Where
- France
- Volunteers
- 22,000 people
- Sponsor
- University Hospital, Tours
Artificial Intelligence, Septic Shock
Artificial Intelligence for Sepsis Prediction in ICU
The development of sepsis prediction model in line with Chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect.
- Conditions
- Artificial Intelligence, Septic Shock, Intensive Care Unit Psychosis
- Trial name
- AICUSepsis (NCT04913181)
- Testing
- Artificial intelligence sepsis prediction model
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Schizophrenia
A Placebo-Controlled, Cross-Over Trial of Aripiprazole
This study is a ten-week, placebo-controlled, double-blind, cross-over, randomized trial of the novel antipsychotic agent, aripiprazole, added to 20 obese stable olanzapine-treated patients with schizophrenia or schizoaffective…
- Trial name
- NCT00351936
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Mental Disorders
Evaluation of an Intervention to Promote Physical Activity in Outpatients With Mental Disorders
The purpose of this study is to determine if a manualised intervention to promote physical activity (MoVo-LISA) is effective to help psychiatric outpatients to increase their level of everyday physical activity.
- Trial name
- GAF (NCT02569619)
- Testing
- Activity Intervention, Healthy Diet Intervention
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Charite University, Berlin, Germany
Schizophrenia
A Study to Evaluate Efficacy and Safety of Bitopertin in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia
This Phase 3, multi-center, randomized, double blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4917838 (bitopertin) in participants with persistent, predominant negative symptoms of…
- Trial name
- NCT01192880
- Testing
- Bitopertin, Antipsychotics
- Where
- 103 sites in United States, Bulgaria and 5 more
- Volunteers
- 625 people
- Sponsor
- Hoffmann-La Roche
Schizophrenia
A Study of Paliperidone Palmitate in Patients With Schizophrenia Previously Unsuccessfully Treated by Oral Antipsychotics
The purpose of this study is to assess the effectiveness, safety and tolerability of flexibly dosed paliperidone palmitate in patients with schizophrenia previously unsuccessfully treated by oral antipsychotics and with acute…
- Trial name
- NCT01685931
- Testing
- Paliperidone Palmitate
- Where
- 17 sites in China
- Volunteers
- 617 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Depression, Anhedonia
Family Promoting Positive Emotions Pilot Study
Anhedonia is characterized by loss of interest or pleasure. The proposed pilot study would be the first to test an innovative, neuroscience-informed intervention in mothers reporting depressive symptoms and stress to enhance…
- Conditions
- Depression, Anhedonia, Stress, Depressive Disorder
- Trial name
- NCT05223842
- Testing
- Family Promoting Positive Emotions (F-PPE), Written Information
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Vanderbilt University
Schizophrenia
What the Nose Knows: Hedonic Capacity, Psychosocial Interventions and Outcomes in Schizophrenia
This project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia.
- Trial name
- NCT05282186
- Testing
- Cognitive Enhancement Therapy, Social Skills Training
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Beth Israel Deaconess Medical Center
Psychosis; Acute, Psychosis
Ketogenic Diet for Psychotic Disorders
Disturbances in glucose metabolism and glutamate neurotransmission feature in the pathophysiology of psychotic disorders. Ketogenic diet (KD) is a high-fat, low-carbohydrate diet that restricts glucose and forces metabolism of…
- Conditions
- Psychosis; Acute, Psychosis, Psychotic Disorders, Schizophrenia
- Trial name
- PsyDiet (NCT03873922)
- Testing
- Ketogenic diet intervention
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Kuopio University Hospital
Schizophrenia, Schizoaffective Disorder
Effects of Antipsychotic Medications on Energy Intake and Expenditure
Aim 1: To evaluate the effect of antipsychotic treatment group on Activity Energy Expenditure. The project hypothesizes that subjects treated with olanzapine will demonstrate a greater decrease in AEE over time than subjects…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Weight Gain
- Trial name
- DLW (NCT00836251)
- Testing
- H218O and 2H2O, administered as a mixed cocktail
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Schizophrenia, Alexithymia
The Effect of Recognition and Expression of Emotions Program Applied to Schizophrenia Patients
As a result of the positive and negative symptoms that occur in schizophrenia, patients with schizophrenia may experience negative emotions more frequently than individuals with other mental problems.
- Conditions
- Schizophrenia, Alexithymia, Emotion, Expressed
- Trial name
- NCT05662137
- Testing
- Emotions Recognition and Expression
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sinop University
Heat Stress, Physiological Stress
Heat Stress in Individuals With Schizophrenia
Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07383324
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Affective Psychosis, Bipolar, Manic Disorder
Phase 3 /Seroquel SR Acute Mania Monotherapy - US
The purpose of this study is to determine the safety and efficacy of sustained-release quetiapine fumarate (Seroquel®) in the treatment of patients with Acute Bipolar Mania for 3 weeks.
- Conditions
- Affective Psychosis, Bipolar, Manic Disorder, Manic-Depressive Psychosis, Mania
- Trial name
- NCT00422123
- Testing
- Quetiapine fumarate (Seroquel) SR
- Where
- 51 sites in United States
- Volunteers
- 447 people
- Sponsor
- AstraZeneca
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
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