Clinical trials: Psychotic Symptoms
Schizophrenia Disorders
Investigating the Effect of Diroximel Fumarate on Glutathione in Schizophrenia
Schizophrenia is a condition that causes symptoms like delusions, hallucinations, reduced motivation and muddled thinking. It is a common, severe and disabling psychiatric illness affecting about 1/100 (1%) of people.
- Trial name
- FORTUNE (NCT06957808)
- Testing
- Diroximel fumarate (DRF)
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Patients With Schizophrenia and Acute Agitation
Staccato Loxapine in Agitated Patients With Schizophrenia
Phase 3 safety and efficacy study of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients
- Trial name
- NCT00628589
- Testing
- Inhaled loxapine 5 mg, Inhaled loxapine 10 mg
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Alexza Pharmaceuticals, Inc.
Bipolar Disorder
Far Infrared Radiation Treatment for Bipolar Condition
A preliminary study to determine the possibility of using far infrared radiation for the treatment of the Bipolar Condition
- Trial name
- NCT00573196
- Testing
- Far infrared
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- GAAD Medical Research Institute Inc.
Schizophrenia
Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
The objective of this study is to compare the modulation of pergolide, a D1/D2 receptor agonist, to placebo in non-acute schizophrenic subjects under concomitant therapy with atypical antipsychotics on specific PFC functions.
- Trial name
- NCT01066403
- Testing
- Pergolide
- Where
- 4 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Heidelberg University
Obesity, Mental Disorder
Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness
People with serious mental illness such as schizophrenia and bipolar disorder experience high rates of physical illness and die earlier than people without serious mental illness (WHO, 2005).
- Trial name
- NCT03382782
- Testing
- BWLI, BWLI & Peer Navigator, Integrated Care
- Where
- 3 sites in United States
- Volunteers
- 234 people
- Sponsor
- Illinois Institute of Technology
Severe Mental Disorder, Metabolic Complication
Effectiveness of a Pragmatic, Metabolic Care Clinic for Patients With Severe Mental Illness - The Meta Care Clinic
This study will examine the effectiveness of a Pragmatic, Metabolic Care Clinic for Patients With Severe Mental Illness
- Conditions
- Severe Mental Disorder, Metabolic Complication, Side-Effect;Medication, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- NCT06624462
- Testing
- Treatment in the Meta Care Clinic, Standard care with general practitioner and/or outpatient clinics
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Bjorn H. Ebdrup
Schizophrenia, Hallucinations
Efficacy of tDCS in the Treatment of Resistant Auditory Hallucinations in Schizophrenia
The regions which are assumed to underlie the pathophysiology of schizophrenia, namely hypoactivity at the prefrontal level and pathological hyperactivity of the associative regions of the language located in the left…
- Conditions
- Schizophrenia, Hallucinations, Refractory Schizophrenia
- Trial name
- TDCSHALLU (NCT04352569)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Prodromal Symptoms, Prodromal Stage
HOPE TEAM - Clinical High Risk Group CBSST
Community-based treatments for adolescents at risk for psychosis are not widely available, nor are there established, gold-standard psychosocial group interventions for this population.
- Conditions
- Prodromal Symptoms, Prodromal Stage, Prodromal States, Psychosis
- Trial name
- NCT03738046
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Sponsor
- University of Pittsburgh
Depression, Affective Disorders, Psychotic
Routine Plasma Level Determination to Compare Actual vs Expected Plasma Levels at Psychiatric Inpatient Admission
Compliance with treatment is notoriously low in psychiatric patients. Traditional methods of monitoring compliance, however, may underreport nonadherence to treatment.
- Trial name
- NCT00627510
- Testing
- Routine psychiatric inpatient treatment
- Where
- Austria
- Volunteers
- 161 people
- Sponsor
- Medical University Innsbruck
Overweight, Pregnancy
Homeopathic Medication and Nutritional Oriented Diet to Treat Overweight Pregnant Women With Mental Disorder
The purpose of this study is to evaluate the efficacy of homeopathic treatment in pregnant women with overweight and class I obesity with suspicion of a mental disorder.
- Conditions
- Overweight, Pregnancy, Mental Disorder
- Trial name
- NCT00942097
- Testing
- Sulph, Puls, Lyc, Lack t, Con, Sep, Nux v, Calc c, Phos, Homeopathy and Nutritional oriented diet
- Where
- Brazil
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Edgard Costa de Vilhena
Mental Disorder, Anxiety
Mental Health, Addictions and Biomarkers in High Athletes Performance
Sport is a privileged area to promote socialization and health values, such as companionship; a healthy lifestyle; cooperation to achieve common goals, and justice, rejecting unjustified advantages in competition.
- Conditions
- Mental Disorder, Anxiety, Depression, Substance Abuse
- Trial name
- NCT04842461
- Where
- 2 sites in Spain
- Volunteers
- 306 people
- Sponsor
- Cardenal Herrera University
Schizophrenia, Psychotic Disorders
The Role of Personal Identity in Psychotic Symptoms: a Study With the Repertory Grid Technique
Personal identity is being recently recognized as a core element for mental health disorders, with relevant clinical implications. However, scarcity of data exists on its role in schizophrenia and related disorders.
- Conditions
- Schizophrenia, Psychotic Disorders, Self
- Trial name
- NCT03820362
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- University of Barcelona
Transcranial Direct Current Stimulation, Schizophrenia
Transcranial Direct Current Stimulation (tDCS) as Therapeutical Strategy for Negative Symptoms in Schizophrenia
The current research is aimed at using Transcranial Direct Current Stimulation (tDCS) as complementary therapeutic tool in the treatment of schizophrenia.
- Trial name
- NCT01623726
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Schizophrenia
Non-interventional Study -Observe Treatment Efficacy in Maintaining Symptoms Control in Schizophrenia With Seroquel XR
the primary purpose of the study is to observe symptoms control in schizophrenia for 6 months in patients treated with Seroquel XR. PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation.
- Trial name
- NCT00750087
- Where
- 32 sites in Romania
- Volunteers
- 578 people
- Sponsor
- AstraZeneca
Tardive Dyskinesia
Pyridoxal Kinase Activity in Tardive Dyskinesia
Objectives: The mechanisms of tardive dyskinesia (TD) remain unclear, although pathophysiologic theories have proposed mechanisms such as dopamine receptor supersensitivity, the degeneration of cholinergic striatal interneurons…
- Trial name
- NCT01908452
- Testing
- Pyridoxine
- Where
- 3 sites in Israel
- Sponsor
- Beersheva Mental Health Center
Schizophrenia
A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia
This is a Phase 3, 6-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with schizophrenia with an inadequate response to their current atypical antipsychotic treatment.
- Trial name
- ARISE (NCT05145413)
- Testing
- Xanomeline and Trospium Chloride Capsules
- Where
- 166 sites in United States, Bulgaria and 6 more
- Volunteers
- 396 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Schizophrenia / Schizoaffective Disorder, Depression / Major Depressive Disorder
Brain Imaging of Cognition Inn Schizophrenia and Depression
Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining…
- Trial name
- NCT04159662
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Other Immunological States or Disorders
The Potential Biomark of Serious Psychosis:a Prospective,Case-controled Study
Patients suffer from Serious Psychosis may have variation in immunological factors,BDNF and MRI.
- Trial name
- NCT02202460
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Central South University
Bipolar Disorder, Schizophrenia
Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder
This is an in-clinic, single arm, open-label study assessing tachyphylaxis, tolerance, and withdrawal following repeated doses of Igalmi in adult males and females with agitation associated with schizophrenia or bipolar disorder.
- Conditions
- Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder
- Trial name
- NCT06041646
- Testing
- Sublingual film containing Igalmi
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- BioXcel Therapeutics Inc
Obesity
Proper Nutrition, Physical Exercise and Appropriate Weight in Individuals With Long Term Mental Illness
Based on previous findings that mentally ill inpatients are interested in losing treatment associate weight gain and are capable of adhering to a weight reduction program, this study will investigate the effects of participation…
- Trial name
- NCT00474227
- Testing
- group therapy, physical exercise, nutrition lectures
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Lev-Hasharon Mental Healtlh Center
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