Clinical trials: Psychotic Symptoms
Parkinson Disease
Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease
OBJECTIVES: I. Determine the efficacy and tolerability of clozapine in ameliorating psychosis in patients with idiopathic Parkinson's disease (PD). II.
- Trial name
- NCT00004826
- Testing
- clozapine
- Volunteers
- 60 people
- Sponsor
- Memorial Hospital of Rhode Island
Schizophrenia, First-Episode
Optimization of Acute Treatment in First Episode Schizophrenia
The study is a multicenter, double-blind, randomized, parallel-group study with first episode schizophrenic patients. During a treatment phase of 8 weeks the patients are treated with Risperidone or Haloperidol.
- Trial name
- NCT00157378
- Testing
- Risperidone, Haloperidol
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Schizophrenia
Enhancing Synaptic Plasticity and Cognition in Schizophrenia
To explore: (a) if physical exercise (sports) combined with cognitive training leads to (superior) improvement of cognition in schizophrenia compared to sports or cognitive training alone (b) if a sports program alone or in…
- Trial name
- EXERCISE-II (NCT01776112)
- Testing
- Exercise, TableSoccer
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Psychological Stresses
Strengths-Based Family Psychoeducation for Youth Psychosis
The onset of Psychosis forces family members to bear a heavy burden of care. The mental well-being of the family is so complicated that it is important to relieve their psychological stresses.
- Trial name
- NCT01731977
- Testing
- Strengths-based family psychoeducation
- Where
- 4 sites in Japan
- Volunteers
- 74 people
- Sponsor
- Nagoya City University
Depression, Bipolar Disorder
Just Do You Program for Young Adults With Serious Mental IIlness
Just Do You is a young-adult-centered and theoretically guided intervention that has shown promise for keeping young adults connected to their professional treatments, while also enhancing their hope for the future and their own…
- Conditions
- Depression, Bipolar Disorder, Psychosis, Anxiety Disorders
- Trial name
- NCT03423212
- Testing
- Just Do You, Active Control
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- New York University
Delirium
The Validity of the Thai Version of the Confusion Assessment Method
The purpose of this study is to determine the validity and reliability of the Thai version of the Confusion Assessment Method for the intensive care (CAM-ICU) in the elderly and the prevalence of delirium in elderly.
- Trial name
- NCT01267630
- Where
- 3 sites in Thailand
- Volunteers
- 70 people
- Sponsor
- Chiang Mai University
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Schizophrenia, Central Obesity
Effect of Dietary Fiber Supplement on the Intestinal Microbiota Among Schizophrenia Patients
Background There has been much interest in the relationship between the types of gut microbiota and the development of obesity in recent years.
- Trial name
- NCT03552237
- Testing
- dietary fiber
- Volunteers
- 40 people
- Sponsor
- TsaoTun Psychiatric Center, Department of Health, Taiwan
Mania, Schizophrenia
Unraveling the Relation of Patient's Profile and Therapeutical Effects of Atypicals, Including Quetiapine Effect
With this observational study we want to examine if the intensity of agitation, the intensity of psychotic symptoms and the presence of sleeping disorder predict the success of the treatment with a atypical antipsychotic after 12…
- Trial name
- UPTAQE (NCT00534222)
- Where
- 6 sites in Netherlands
- Volunteers
- 387 people
- Sponsor
- AstraZeneca
Schizophrenia, Negative Symptoms
Effective Adjunctive Use of Pergolide for Cognitive Impairment and Negative Symptoms in Schizophrenia
Dopamine has been closely associated with prefrontal function. The hypothesis that a lower dopaminergic activity is associated with negative symptoms and cognitive dysfunction observed in the patients of schizophrenia is of a…
- Conditions
- Schizophrenia, Negative Symptoms, Cognitive Impairments
- Trial name
- NCT00197483
- Testing
- Pergolide (drug)
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Hamamatsu University
Schizophrenia, Schizoaffective Disorder
Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia
The aim of the project is to investigate the use of Raloxifene (a new form of estrogen) in the treatment of young women with schizophrenia and schizoaffective disorder.
- Trial name
- NCT02354001
- Testing
- Raloxifene hydrochloride
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- The Alfred
Schizophrenia
Schizophrenia and Physical Exercise
Schizophrenia is a severe mental illness, of psychosis being the most prevalent in society, affecting 1% of the population. The treatment of schizophrenia is basically done with antipsychotic drugs, although other…
- Trial name
- NCT01595698
- Testing
- Physical Exercise, Control
- Where
- Brazil
- Volunteers
- 11 people
- Sponsor
- Federal University of São Paulo
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Mental Disorder, Schizophrenia Diagnosis
Validation of a VOICE MAnagement Program in Schizophrenia VVoice MAPS
Approximately 25-50% of patients with schizophrenia experience treatment-resistant Auditory Verbal Hallucinations (AVHs), which contribute to the development of associated psychopathological disorders (e.g., anxiety, depression…
- Trial name
- PROGEVs (NCT07266376)
- Testing
- Integrative group therapy
- Where
- Guadeloupe
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Mental Disorders, Schizophrenia
STIM'ZO : Examining tDCS as an add-on Treatment for Persistent Symptoms in Schizophrenia
This project aims to provide the proof of concept for transcranial direct-current stimulation (tDCS) in the treatment of resistant/persistent Schizophrenia symptoms.
- Trial name
- STIM'ZO (NCT02744989)
- Testing
- Neuroconn or Neuroelectric tDCS stimulator
- Where
- 10 sites in France, Monaco
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Schizophrenia Spectrum Disorders, Cannabis Use
Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis
A large proportion of people with a schizophrenia-spectrum disorder, especially in the early stages of the disease, regularly consume cannabis.
- Trial name
- NCT03883360
- Testing
- Cannabidiol (CBD)
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore
Schizophrenia Spectrum Disorders, Negative Symptoms in Schizophrenia
ENGAGE: Virtual Reality-based Psychotherapy for Negative Symptoms in Schizophrenia
The primary goal of this pilot study is to examine the feasibility and acceptability of a new Virtual Reality-based intervention against negative symptoms in schizophrenia spectrum disorders (SSD).
- Trial name
- ENGAGE (NCT06993831)
- Testing
- Virtual Reality-based psychotherapy
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
MBSR, Caregiver
The Effect of Mindfulness-Based Stress Reduction Program
This randomized controlled study evaluate the effect of the Mindfulness-Based Stress Reduction Program on the state-trait anxiety, hopelessness, self-compassion and care burden of the families of psychotic patients.
- Trial name
- Mindfulness (NCT05245305)
- Testing
- Mindfulness Based Stress Reduction Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mersin University
Schizophrenia, Schizoaffective Disorder
Motivational Negative Symptoms in Schizophrenia: Intervention and Biomarkers
Negative symptoms significantly interfere with daily functioning among individuals with schizophrenia. They are strongly related to functional impairments [1] and contribute to the poor community outcomes of Veterans with…
- Trial name
- NCT02386605
- Testing
- Motivational Interviewing and Cognitive Behavioral Therapy, Relaxation Skills
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- VA Office of Research and Development
Schizoaffecitve Disorder, Schizophrenia and Schizoaffective Disorder
Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
In following guidelines for studying negative symptoms in schizophrenia, 60 patients aged 18-40, diagnosed with schizophrenia or schizoaffective disorder during the last ten years, will receive a combination of the iron chelator…
- Conditions
- Schizoaffecitve Disorder, Schizophrenia and Schizoaffective Disorder, Schizophrenia and Predominant Negative Symptoms
- Trial name
- IronMan (NCT07759895)
- Testing
- Deferiprone (DFP), N-Acetyl Cysteine (NAC)
- Where
- 2 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Amit Lotan
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