Clinical trials: Pterygium
Dry Eye
Tear Layer Lipid Thickness in Pterygium Patient Before and After Surgery
The investigators study aims to capture the objective effects of pterygium surgery on tear layer lipid thickness and the tear layer.
- Trial name
- NCT02160769
- Where
- Singapore
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Corneal Topography
Comparison Between Bare Scleral Technique and Conjunctival Auto-graft on Corneal Topography After Pterygium Surgery
Aim of the work: To study the corneal topographic pattern changes in patients who have pterygium excision by two surgical techniques (bare sclera, conjunctival autograft).
- Trial name
- NCT05812508
- Testing
- corneal topography
- Volunteers
- 30 people
- Sponsor
- Sohag University
Pterygium
Risk Factors and Biomarkers Associated With Recurrence After Excision of Primary Pterygium
This study looks at global gene expression in pterygium and found the derangement of matrix genes in particular to be a feature of pterygium.
- Trial name
- NCT01068496
- Where
- 2 sites in Singapore
- Volunteers
- 1 people
- Sponsor
- Singapore National Eye Centre
Ophthalmopathy, Artificial Intelligence
Validation of the Utility of Ophthalmology Intelligent Diagnostic System
The prevention and treatment of diseases via artificial intelligence represents an ultimate goal in computational medicine. Application scenarios of the current medical algorithms are too simple to be generally applied to…
- Trial name
- NCT03499145
- Testing
- Ophthalmology diagnostic system.
- Where
- China
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Recurrent Pterygium
Recurrent Pterygium Surgery Using Mitomycin C With Limbal Conjunctival or Amniotic Membrane
To compare the outcomes of limbal conjunctival autograft (LCAG) versus amniotic membrane graft (AMG) when combined with intraoperative 0.02% mitomycin C (MMC) after pterygium removal in patients with recurrent pterygium.
- Trial name
- NCT01319721
- Testing
- MMC, LCAG, AMG
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shiyou Zhou
Pterygium of Conjunctiva and Cornea
Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery
Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. It is a progressive disease that may lead to visual impairment in advanced stages, as well as restriction of ocular motility, chronic inflammation and…
- Trial name
- NCT03321201
- Testing
- Cauterization, Fibrin glue
- Where
- Croatia
- Volunteers
- 164 people
- Sponsor
- University of Split, School of Medicine
Pterygium, Corneal Astigmatism
Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea.
- Trial name
- NCT07198126
- Testing
- Pterygium Excision with Conjunctival Autograft
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Mughal Eye Trust Hospital
Autosomal Dominant Retinitis Pigmentosa, Eye Diseases
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
This study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in subjects receiving a single dose or repeat doses.
- Conditions
- Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies
- Trial name
- AURORA (NCT04123626)
- Testing
- QR-1123
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- ProQR Therapeutics
Cataract, Retina Detachment
Different Hemostasis According to the Anesthetic Agents
We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability…
- Conditions
- Cataract, Retina Detachment, Pterygium, Keratitis
- Trial name
- NCT02151305
- Testing
- Propofol, remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Bundang Hospital
Homozygous Familial Hypercholesterolemia
HoFH, the International Clinical Collaborators Registry
Homozygous familial hypercholesterolemia (HoFH), a rare inherited disorder caused by bi-allelic mutations in the LDL Receptor pathway, is characterized by extremely elevated levels of low-density lipoprotein cholesterol (LDL-C)…
- Trial name
- HICC (NCT04815005)
- Testing
- Demographics, diagnosis type, genotype, lipid profile, treatment allocation, country of residence.
- Where
- 4 sites in United States, Netherlands and 1 more
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Pterygium
Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia
The purpose of this study is to determine if there is any difference in the surgical time when the surgery is performed with a graft taken from under the upper lid versus lower lid.
- Trial name
- NCT01261455
- Testing
- Location of the autograft taken following pterygium excision
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Pterygium
Safety and Efficacy of Cyclosporine Ophthalmic Emulsion in Patients With Primary Pterygium
This study will evaluate the safety and efficacy of Cyclosporine Ophthalmic Emulsion 0.05% (RESTASIS®) in patients with primary pterygium (abnormal growth on surface of eye).
- Trial name
- NCT01109056
- Testing
- cyclosporine ophthalmic emulsion 0.05%, Vehicle
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 115 people
- Sponsor
- Allergan
Pterygium, Cataract
Surgical Treatment of Concurrent Cataract and Primary Pterygium
Pterygium is known to induce with-the-rule astigmatism. The corneal curvature along the long axis of the pterygium body is flattened. The excision of pterygium will result in steepening of the cornea and reduction of astigmatism.
- Conditions
- Pterygium, Cataract, Lenses, Intraocular
- Trial name
- NCT00563277
- Testing
- combined pterygium and cataract operation, pterygium excision followed by cataract operation
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- Hospital Authority, Hong Kong
Malformations, Multiple Abnormalies
Phenotype and Etiology of Pallister-Hall Syndrome
We aim to delineate the range of severity, natural history, molecular etiology, and pathophysiology of Pallister-Hall syndrome (PHS), Greig cephalopolysyndactyly syndrome (GCPS), McKusick-Kaufman syndrome (MKS), Bardet-Biedl…
- Conditions
- Malformations, Multiple Abnormalies, Polydactyly
- Trial name
- NCT00001404
- Where
- 4 sites in United States, Turkey (Türkiye)
- Volunteers
- 1,170 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Pterygium
RMP-A03 Ocular Suspension in Patients With Pterygium
The goal of this clinical trial is to test the safety and efficacy of an ocular medication on the treatment of pterygium.
- Trial name
- NCT05794204
- Testing
- RMP-A03 - Dose 1, RMP-A03 - Dose 2
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Suzhou Raymon Pharmaceuticals Company, Ltd.
Pterygium
A Study of the Response to AG-86893 in Patients With Pterygium Hyperemia
A pterygium is a wing-shaped, benign tissue growth which forms on the surface of the conjunctiva and grows towards the cornea. It can eventually lead to vision impairment.
- Trial name
- SURPH (NCT03533244)
- Testing
- 0.1% AG-86893 Eye Drops, 0.3% AG-86893 Eye Drops, Vehicle Eye Drops
- Where
- 6 sites in Australia
- Volunteers
- 64 people
- Sponsor
- Allgenesis Biotherapeutics Inc.
Dry Eye Syndromes, Pterygium
Assessment of the Efficacy of Ocular Dipyridamole in the Treatment of Dry Eye Symptomology in Subjects With Pterygium
Subjects with pterygium and associated dry eye symptoms (DES) are randomized into an active cohort (receiving ocular administration of Dipyridamole) or placebo cohort (ocular administration of vehicle).
- Trial name
- NCT02782260
- Testing
- Dipyridamole
- Volunteers
- 40 people
- Sponsor
- Ariel University
Pterygium
Bevacizumab for Primary Pterygium Treatment
The aim of this study was to investigate the efficacy and safety of subconjunctival bevacizumab application as an adjuvant therapy for primary pterygium.
- Trial name
- NCT01686529
- Testing
- Autoconjunctival grafting, Subconjuntival bevacizumab injection
- Where
- Mexico
- Volunteers
- 49 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Pterygium
Comparison Between Topical Mitomycin C and Cyclosporine
Pterygium is a disease associated with proliferation of the fibrovascular tissues of the conjunctiva into the cornea and is related to factors such as ultraviolet light exposure, chronic stimulation, inflammation, climate, and…
- Trial name
- NCT05627947
- Testing
- Mitomycin c
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Egymedicalpedia
Primary Pterygium
Comparison of Compressed Continuous Suture and Conventional Suture in Pterygium Surgery
To compare the advantages and disadvantages of continuous suture with suture and conventional Suture in primary pterygium surgery for autologous conjunctival graft fixation
- Trial name
- NCT07244276
- Testing
- Compression continuous suture with suture crimping, Conventional Suture with suture crimping
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital