Clinical trials: Ptosis
Pelvic Organ Prolapse
IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair
The purpose of this study is to determine whether preoperative IV Acetaminophen reduces postoperative pain and narcotic consumption in women undergoing surgical repair of pelvic organ prolapse.
- Trial name
- NCT02155738
- Testing
- IV Acetaminophen, IV normal saline
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Halina M Zyczynski, MD
Pelvic Organ Prolapse
Same Day Discharge After Minimally-invasive Sacrocolpopexy
This is a prospective cohort study evaluating safety, cost and patient satisfaction with SDD for patients undergoing minimally invasive sacrocolpopexy for pelvic organ prolapse.
- Trial name
- NCT03730103
- Testing
- Same day discharge
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse
Uterosacral Ligament Suspension Clip
This study seeks to gain a more thorough understanding of the postoperative location of the sutures placed during uterosacral ligament suspension.
- Trial name
- USLS (NCT02700997)
- Testing
- Vascular Clip
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- TriHealth Inc.
Anterior Vaginal Wall Prolapse, Cystocele
Anterior Colporrhaphy Versus Cystocele Repair Using Polypropylene Mesh or Porcine Dermis
The purpose of this study is to evaluate the success rate of cystocele repair using polypropylene mesh or porcine dermis compared to that of anterior colporrhaphy in a prospective randomized fashion.
- Conditions
- Anterior Vaginal Wall Prolapse, Cystocele, Pelvic Organ Prolapse
- Trial name
- OARS (NCT01393171)
- Testing
- Polypropylene mesh (Polyform by Boston Scientific), Porcine Dermis (Pelvicol by CRBard), Anterior Colporrhaphy
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Ptosis, Eyelid, Conjunctiva Inflamed
The Effect of Upneeq (Oxymetazoline Hydrochloride 0.1%) on Eyelid Position, Eye Redness, and Eye Appearance
The purpose of the research is to see if Upneeq ( oxymetazoline 0.1% ophthalmic solution) has an effect on eyelid position, eye redness, or patient-perceived appearance of the eyes.
- Conditions
- Ptosis, Eyelid, Conjunctiva Inflamed, Eye Manifestations
- Trial name
- NCT04831047
- Testing
- Oxymetazoline hydrochloride 0.1% ophthalmic solution
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Miami
Urinary Retention, Lower Urinary Tract Symptoms
Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery
This is a placebo controlled randomized controlled trial of perioperative use of tamsulosin to prevent postoperative urinary retention in female pelvic reconstructive surgery.
- Conditions
- Urinary Retention, Lower Urinary Tract Symptoms, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT03524339
- Testing
- Tamsulosin
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Hemorrhoids
Comparison Study of Surgical Staplers for the Treatment of Hemorrhoids
The purpose of this study is to demonstrate that the Covidien EEA™ Hemorrhoid and Prolapse Stapling Set for the treatment of hemorrhoids is non-inferior to the competitor device based on the primary endpoint.
- Trial name
- HEMOSTASIS (NCT01306877)
- Testing
- EEA Hemorrhoid and Prolapse Stapling Set, Endosurgery Proximate PPH03 Stapling Set
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Medtronic - MITG
Urethra Issue, Pelvic Organ Prolapse
Lessons on Urethral Lidocaine in Urodynamics
This trial will assess whether use of intraurethral 2% lidocaine jelly meaningfully impacts sensation during filling (i.e., a change of more than 25% of first sensation, first desire to void, strong desire to void, or maximum…
- Conditions
- Urethra Issue, Pelvic Organ Prolapse, Urinary Incontinence, Vaginal Vault Prolapse
- Trial name
- LULU (NCT04038099)
- Testing
- Water-Based Vaginal Lubricant, lidocaine topical
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Texas Southwestern Medical Center
Acquired Blepharoptosis
LEV102 Topical Gel in Acquired Blepharoptosis
Phase 1/2a, multicenter, randomized, vehicle-controlled, double-masked, multiple-dose, parallel-group study conducted in adult subjects with acquired blepharoptosis.
- Trial name
- NCT05715346
- Testing
- LEV102 1.0%, LEV102 2.0%, Vehicle
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Levation Pharma, Ltd.
Blepharoptosis, Ptosis, Eyelid
Clinical Trial to Improve the Magnetic Levator Prosthesis
Blepharoptosis (incomplete opening of the eyelids) occurs because of a disruption in the normal agonist-antagonist neuro-muscular complex balance. An external device could restore eyelid movement.
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT03818204
- Testing
- Magnetic Levator Prosthesis (MLP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pelvic Organ Prolapse, Perioperative/Postoperative Complications
Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery
This study will recruit women scheduled to undergo vaginal apical suspension surgery (either uterosacral ligament suspension or sacrospinous ligament fixation) with or without other prolapse or anti-incontinence procedures.
- Trial name
- NCT05658887
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Joseph Kowalski
Pelvic Organ Prolapse
Physical Therapy Intervention for Pelvic Organ Prolapses
Pelvic floor muscle training (PFMT) and pessaries are first-line non-surgical conservative treatments for pelvic organ prolapse (POP).
- Trial name
- NCT06532292
- Testing
- Biofeedback, HIFEM
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- National Taiwan University Hospital
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Pelvic Organ Prolapse
FINPOP 2015: Incidence, Methods, Complications and Quality of Life of Pelvic Organ Prolapse Operations in Finland 2015
The aim of this study is to investigate the safety and effectivity of pelvic organ prolapse (POP) surgery. In this multi center study the population consists of POP operations done in Finland year 2015.The study is prospective…
- Trial name
- NCT02716506
- Testing
- POP surgery
- Where
- Finland
- Volunteers
- 3,515 people, healthy volunteers welcome
- Sponsor
- Society for Gynecological Surgery in Finland
Intervertebral Disk Displacement, Disk Prolapse
Analgetic and Anxiolytic Effect of Preoperative Pregabalin
The purpose of this study is to determine whether the use of oral pregabalin 150 mg as premedication reduces the amount and degree of postoperative pain.
- Trial name
- NCT00353704
- Testing
- pregabalin, morphine
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Asker & Baerum Hospital
Mitral Valve Insufficiency, Heart Valve Diseases
NeoChord TACT Post-Market Surveillance Registry
To monitor the long-term performance of the CE Marked NeoChord Artificial Chordae Delivery System
- Conditions
- Mitral Valve Insufficiency, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT01784055
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 126 people
- Sponsor
- NeoChord
Mitral Valve Insufficiency, Mitral Valve Regurgitation
Pivotal Study of a Percutaneous Mitral Valve Repair System
EVEREST II Randomized Controlled Trial (RCT) is a prospective, multi-center, randomized study of the MitraClip® System in the treatment of mitral valve regurgitation, randomizing patients to MitraClip or mitral valve surgery.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- EVERESTIIRCT (NCT00209274)
- Testing
- Percutaneous mitral valve repair using MitraClip implant, Mitral valve repair or replacement surgery
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Abbott Medical Devices
Genital Diseases, Female, Pelvic Organ Prolapse
A Long Term Follow up of Anterior Meshes for Recurrent Prolapse
Prolapse of the vaginal wall and uterus are common conditions affecting up to 50% of parous women. The socioeconomic, psychological and physical impacts of prolapse are considerable.
- Trial name
- NCT02642835
- Testing
- vaginal wall mesh
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Medway NHS Foundation Trust
Pelvic Organ Prolapse
Calistar A vs. Calistar S - Comparative Cohort Retrospective Analysis of Single Incision POP Systems
The main objective of this study is to compare the initial outcomes and complication of two meshes implanted through a single incision to treat anterior and apical prolapses, Calistar A and a second-generation low weight mesh…
- Trial name
- NCT03715803
- Testing
- Calistar A mesh to treat anterior and apical POP, Calistar S mesh to treat anterior and apical POP
- Where
- Argentina
- Volunteers
- 217 people
- Sponsor
- Agustin Sampietro
Quality of Recovery, Same Day Surgery
Dexamethasone Administration To Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There A Role?
To the investigators knowledge there are no studies in the literature evaluating the effect of Dexamethasone administration on patients undergoing outpatient vaginal prolapse surgeries.
- Conditions
- Quality of Recovery, Same Day Surgery, Nausea and Vomiting, Postoperative, Vaginal Prolapse
- Trial name
- NCT03338400
- Testing
- Dexamethasone, Normal saline
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic