Clinical trials: Puberty
Central Precocious Puberty
A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty.
The purpose of the protocol is to assess the efficacy of the triptorelin 6 month PR (Prolonged Release) formulation in suppressing LH (Luteinising hormone) levels to prepubertal levels (defined as a peak LH ≤5 IU/L) after i.v.
- Trial name
- NCT05029622
- Testing
- Triptorelin Pamoate
- Where
- 14 sites in China
- Volunteers
- 66 people
- Sponsor
- Ipsen
COVID19- Infection with SARS-CoV-2 Virus
Impact of the COVID-19 Pandemic on Central Precocious Puberty: a Retrospective Cohort Study from Turkey
Objective: This study investigates the clinical and demographic characteristics of girls diagnosed with central precocious puberty (CPP) in the pre-pandemic and pandemic periods to assess potential changes during the COVID-19…
- Trial name
- COVID-19-PP (NCT06823076)
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Umraniye Education and Research Hospital
Central Precocious Puberty (CPP)
Diagnostic Power of Basal LH Compared to Peak LH After Stimulus Test in the Diagnosis of Central Precocious Puberty
This is an observational, retrospective, single-center study focused on the diagnosis of Central Precocious Puberty in female patients.
- Trial name
- NCT06720623
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Puberty, Healthy
Negative Emotionality and Epigenetics During Puberty
Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty.
- Conditions
- Puberty, Healthy, Stress
- Trial name
- NCT06690866
- Testing
- Stress
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Pubertal Delay, Hypogonadism, Hypogonadotropic
Triptorelin for Early Diagnosis of Hypogonadotrophic Hypogonadism
The goal of this clinical trial is to learn if Triptorelin test works to early diagnose hypogonadotrophic hypogonadism in adolescents.
- Conditions
- Pubertal Delay, Hypogonadism, Hypogonadotropic, Constitutional Delay in Growth and Puberty (CDGP)
- Trial name
- NCT06691815
- Testing
- Triptorelin (GnRH agonists)
- Where
- Argentina
- Volunteers
- 48 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Amenorrhea, Oligomenorrhea
Ovarian Morphology in Girls
Establishment of regular menstrual cycles is a key component of reproductive maturation and a recognized vital sign for health and well-being.
- Conditions
- Amenorrhea, Oligomenorrhea, Puberty
- Trial name
- OMG (NCT04424576)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cornell University
Central Precocious Puberty
Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty.
The purpose of this research was to confirm the effectiveness and safety of the study drug, Triptorelin pamoate 15mg 3-month formulation, in a Chinese population of Central Precocious Puberty (CPP) children.
- Trial name
- NCT04736602
- Testing
- Triptorelin pamoate 15mg
- Where
- 7 sites in China
- Volunteers
- 32 people
- Sponsor
- Ipsen
Central Precocious Puberty
Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP
The primary objective of this study is to compare the efficacy of the 3-month formulation and 1-month formulation of triptorelin and to assess the short-term effects of the 3-month formulation of triptorelin on glucose and lipid…
- Trial name
- NCT06487143
- Testing
- Triptorelin pamoate（15mg）, Triptorelin acetate （3.75mg）
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Disorders of Sex Development, Growth Disorders
Identifying New Genetic Causes to Development Disorders
Disorders of growth, puberty and sex development can have genetic causes. The exome analysis could detect new mutations responsible for these disorders and the frequency of these mutations in these disorders, their association…
- Conditions
- Disorders of Sex Development, Growth Disorders, Puberty Disorders
- Trial name
- FORDEV (NCT03283852)
- Testing
- blood sample
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Central Precocious Puberty (CPP)
A Study to Evaluate Leuprolide Acetate 45 mg 6-Month Formulation in Children With Central Precocious Puberty (CPP)
The primary objective of the study is to assess the safety and efficacy of a leuprolide acetate (LA) 45 mg 6-month depot formulation for the treatment of CPP in children who are either naïve to treatment with a…
- Trial name
- NCT03695237
- Testing
- Leuprolide Acetate (LA)
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 45 people
- Sponsor
- AbbVie
Acne Vulgaris, Gingivitis
Association of Acne Vulgaris With Oral Hygiene and Gingivitis
The goal of this observational study is to learn about in the relationship between acne vulgaris and oral hygiene and gingivitis.
- Conditions
- Acne Vulgaris, Gingivitis, Dental Plaque, Oral Hygiene
- Trial name
- NCT06237387
- Testing
- Periodontal examination
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Precocious Puberty
Evaluation of the Correlation Between Psychological Intervention, Including Providing Knowledge and Tools for Problems Solving, and the Anxiety Level of Female Patients Arriving to ACTH LRH Test - Pilot Study
Over 20% of the population is reporting on "white coat syndrome", manifested as anxiety symptoms and elevated BP during interaction with medical staff.
- Trial name
- NCT04502836
- Testing
- Preliminary psychological intervention
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Rabin Medical Center
Puberty, Precocious, McCune-Albright Syndrome
Faslodex in McCune-Albright Syndrome
The purpose of this study is to evaluate the safety, effectiveness and pharmacokinetics of a study drug called Faslodex (fulvestrant) in the treatment of progressive precocious puberty (PPP) (early puberty) in girls with…
- Trial name
- FMAS (NCT00278915)
- Testing
- Fulvestrant
- Where
- 16 sites in United States, France and 4 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Delayed Puberty, Male Hypogonadism
Testosterone Undecanoate Replacement Therapy in Boys With Pubertal Delay or Confirmed Hypogonadism
The absence of clinical signs of pubertal maturation, i.e. pubertal delay, is a relatively frequent reason for consultation in boys.
- Trial name
- NCT05541172
- Testing
- Testosterone Undecanoate
- Where
- Argentina
- Volunteers
- 27 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Idiopathic Precocious Puberty
Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine
Our study used a randomized controlled trial to validate the clinical efficacy of a combination of traditional Chinese and Western medicine in the treatment of children with rapid progressive central precocious puberty.
- Trial name
- NCT03963752
- Testing
- Ziyinxiehuo Granules Herbs, Megestrol Acetate Tablet, Leuprorelin Acetate 3.75mg Injection
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Children's Hospital of Fudan University
Puberty, Puberty, Precocious
The 3rd COPENHAGEN Puberty Study
The COPENHAGEN School Study is a combined cross-sectional and longitudinal study of healthy Danish school children. This study will by clinical examinations and withdrawal of blood samples investigate whether age of pubertal…
- Trial name
- NCT04884620
- Where
- Denmark
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Ovary Syndrome, Hyperandrogenism
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low.
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
- Trial name
- NCT01428089
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Puberty, Hyperandrogenism
Assessment of Day-night Secretion of Progesterone and LH Across Puberty
Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones.
- Trial name
- LH (NCT02155933)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Hyperandrogenism
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia
Polycystic ovary syndrome (PCOS) is a common disorder marked by hyperandrogenism, oligo-/anovulation, and subfertility. The precise causes of PCOS are unclear, but the pathophysiology involves complex genetic and environmental…
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Puberty
- Trial name
- DENND1A (NCT02611128)
- Testing
- Phenotype/genotype assessment
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Puberty Disorders
Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Puberty Disorders, Ovulation Disorder
- Trial name
- CBS009 (NCT04075149)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia