Clinical trials: Puberty
Overweight, Leanness
The Effects of Puberty and Weight on Sugar Metabolism in Children
Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal.
- Conditions
- Overweight, Leanness, Adolescent
- Trial name
- NCT01718080
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obesity Prevention
Television Viewing (TVV) & Puberty on Lunchtime Food Intake
The investigators hypothesize that television viewing will affect food intake in adolescent girls, and will depend on pubertal stage.
- Trial name
- NCT01025687
- Testing
- water with noncalorie sweetener, water with glucose, TV program showed while feeding
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Methylation, Body Composition
Diet and Nutrition Pilot Study for Chinese Adolescents and Their Mothers
Background: Researchers want to collect information on diet, physical activity, and sun exposure in children and young adults. The data can provide information on the effect these factors might have on the development of cancer…
- Conditions
- Methylation, Body Composition, Physical Activity, Puberty
- Trial name
- NCT01517139
- Where
- China
- Volunteers
- 278 people
- Sponsor
- National Cancer Institute (NCI)
Klinefelter Syndrome
Klinefelter Syndrome and Testosterone Treatment in Puberty
The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY).
- Trial name
- TiPY (NCT06294990)
- Testing
- Testosterone gel
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Lise Aksglæde
Precocious Puberty, Central
Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty
This study determines the effectiveness of leuprolide acetate 45 mg for injectable suspension for treatment of children with Central Precocious Puberty.
- Trial name
- NCT02452931
- Testing
- Leuprolide Acetate 45 mg
- Where
- 20 sites in United States, Argentina and 4 more
- Volunteers
- 64 people
- Sponsor
- Tolmar Inc.
Precocious Puberty
Treatment of Boys With Precocious Puberty
This study is a continuation of two previous studies conducted at the NIH. The first study , "Treatment of True Precocious Puberty with a Long-Acting Lutenizing Hormone Releasing Hormone Analog (D-Trp(6)-Pro(9)-Net-LHRH)" had…
- Trial name
- NCT00001202
- Testing
- Spironolactone, Testolactone, Deslorelin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Constitutional Growth Delay, Nutrition Disorders
Nutrients and Hormones: Effects in Boys With Disordered Growth
The purpose of the study is to find out if patients with constitutional delay of growth have a mismatch between energy intake and utilization (as measured by doubly labeled water) and to compare the improvement in growth and…
- Conditions
- Constitutional Growth Delay, Nutrition Disorders, Growth Disorders
- Trial name
- NCT00139451
- Testing
- Pediasure, GH
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nemours Children's Clinic
Precocious Puberty
LH Response to GnRH Test in Prepubescent Girls Under 6 Years
The project aims to establish the normal LH and FSH response to a standardized GnRH dose in healthy girls below 6 years of age, and compares the normal GnRH response to the GnRH response in girls with early puberty development.
- Trial name
- NCT01944488
- Testing
- GnRH agonist
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Central Precocious Puberty
Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty
This is a prospective, multicentric, comparative, non-randomized interventional study in which subjects diagnosed with central precocious puberty (CPP) and early puberty (EP) were treated for 6 months to compare the effect with…
- Trial name
- NCT02920515
- Testing
- Triptorlin or Leuprorelin, Zhibo dihuang pills, Dabu ying pills
- Volunteers
- 740 people
- Sponsor
- Ruijin Hospital
PCOS (Polycystic Ovary Syndrome), Puberty
ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence
This study explores how a physical activity program can affect hormone health and diabetes risk in girls ages 8-12 who may be at higher risk.
- Conditions
- PCOS (Polycystic Ovary Syndrome), Puberty, Insulin Resistance, Physical Activity
- Trial name
- NCT07102797
- Testing
- ActiveGirls Physical Activity Program (Full), ActiveGirls Physical Activity Program (Delayed Lower Intensity)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Headache, Gender Identity
Effect of Hormones on Frequency of Headache and Brain Structure and Function in Puberty
With a rising population of transgender adults and youth, there is a need for more research to meet the needs of this community.
- Trial name
- NCT05607303
- Testing
- Clinical estrogen therapy
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Central Precocious Puberty
Markers of Pubertal Suppression During Therapy for Precocious Puberty
The best way to measure whether treatment of children with central precocious puberty is working is to do a hormone stimulation test (leuprolide stimulation test) that requires injection of a medication and multiple blood draws…
- Trial name
- NCT02006680
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Klinefelter Syndrome
Fertility Assessment in Patients With Klinefelter Syndrome
Klinefelter syndrome is characterized by primary testicular failure and progressive infertility. The objective of this study is to determine if sperm are present and can be observed in semen samples of adolescent and young adult…
- Trial name
- NCT02461303
- Testing
- Counseling
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Idiopathic Precocious Puberty
Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine
Our study used a randomized controlled trial to validate the clinical efficacy of a combination of traditional Chinese and Western medicine in the treatment of children with rapid progressive central precocious puberty.
- Trial name
- NCT03963752
- Testing
- Ziyinxiehuo Granules Herbs, Megestrol Acetate Tablet, Leuprorelin Acetate 3.75mg Injection
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Children's Hospital of Fudan University
Hyperandrogenism, Polycystic Ovary Syndrome
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CRM008 (NCT03068910)
- Testing
- Micronized progesterone, Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Precocious Puberty
Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study
The purpose of the protocol is to assess the efficacy of triptorelin 11.25 mg with respect to the proportion of children who maintain a regression or stabilisation of sexual maturity until the end of the study.
- Trial name
- DECAPUB (NCT00909844)
- Testing
- Triptorelin (I.N.N.)
- Where
- 10 sites in France
- Volunteers
- 35 people
- Sponsor
- Ipsen
Central Precocious Puberty
Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty
A multicenter, open-label, prospective study to evaluate the safety and efficacy of leuprorelin acetate DPS (Leuplin DPS) treatment quarterly in patients with central precocious puberty
- Trial name
- NCT03316482
- Testing
- Leuplin DPS 11.25mg
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Jin Soon Hwang
Precocious Puberty
Purification of Testis-Stimulating Factor in Precocious Puberty
OBJECTIVES: Purify and characterize a testis-stimulating factor in the blood of adult volunteers who had precocious puberty as boys.
- Trial name
- NCT00004344
- Testing
- leuprolide, testosterone
- Volunteers
- 4 people
- Sponsor
- National Center for Research Resources (NCRR)
Central Precocious Puberty (CPP), Puberty Disorders
Spexin and Phoenixin-20 in Girls With Central Precocious Puberty
Central precocious puberty (CPP) is characterized by the early activation of the hypothalamic-pituitary-gonadal axis in girls and may be difficult to distinguish from benign variants such as premature thelarche.
- Conditions
- Central Precocious Puberty (CPP), Puberty Disorders, Puberty, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
- Trial name
- SPX-PNX-CPP-20 (NCT07359092)
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital