Clinical trials: Puerperal Disorder
Von Willebrand Diseases
Von Willebrand Factor in Pregnancy (VIP) Study
In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is lacking for delivery planning in…
- Trial name
- VIP (NCT04146376)
- Testing
- Use of a postpartum diary and additional blood draws, VWF replacement therapy with Wilate, Tranexamic acid
- Where
- 11 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Washington
Postpartum Hemorrhage
Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study
Postpartum hemorrhage (PPH) is the loss of more than 500ml of blood within 24 hours after delivery. It is a major cause of maternal morbidity and mortality across the globe.
- Trial name
- NCT02647268
- Testing
- Oxytocin, Magnesium Sulphate
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Depression, Postpartum
MOVIN Pilot Randomized Controlled Trial
Despite available treatments for perinatal mood disorders, only 20% of affected women receive treatment that results in remission of symptoms.
- Trial name
- MOVIN (NCT04680585)
- Testing
- Enhanced Usual Care, MOVIN Care Platform
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- Women's College Hospital
Postpartum Haemorrhage (PPH)
Temporary Aortic Occlusion With the Abdominal Tourniquet for Refractory Postpartum Haemorrhage: A Proof-of-Concept Study in a War-Affected Region
The purpose of this study is to evaluate whether a medical device called the Abdominal Aortic and Junctional Tourniquet - Stabilized (AAJT-S) can safely and effectively temporarily stop severe bleeding after childbirth (known as…
- Trial name
- TAOAT (NCT07016568)
- Testing
- Abdominal Aortic and Junctional Tourniquet - Stabilized (AAJT-S)
- Where
- Ukraine
- Volunteers
- 4 people
- Sponsor
- LLC UkrMedGroup
Postpartum Hemorrhage, Twin Pregnancy
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies.
- Trial name
- CUTT-PPH (NCT07401524)
- Testing
- Carbetocin, Oxytocin
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
COVID-19, Pregnant Women
Qatar PREgnancy Covid-19 OUtcome Study
The in-utero exposure of acute viral infection in some instances is proven to have short- and long-term neonatal effects during the postnatal and childhood period and the Zika virus, measles, mumps, and rubella are few examples.
- Trial name
- QPRECIOUS (NCT05349279)
- Where
- Qatar
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Post Partum Haemorrhage
Combined Use of Oxytocin and Misoprostol Versus Oxytocin Infusion and Misoprostol Alone to Reduce Blood Loss at Cesarean Section
The purpose of this study is to demonstrate that the combined used of low dose of oxytocin and misoprostol prevent from post partum haemorrhage better than oxytocin or misoprostol alone at cesarean sectionOne hundred fifty women…
- Trial name
- NCT01571323
- Testing
- Misoprostol, Oxytocin, Oxytocin and Misoprostol
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Qazvin University Of Medical Sciences
Postpartum Depression
Public Health Nurse-Peer Co-Led Group Cognitive Behavioral Therapy for Postpartum Depression
The purpose of this study is to determine the effectiveness of an online 9-week group Cognitive Behavioural Therapy (CBT; a type of talking therapy) intervention that is co-led by public health nurses (PHNs) and individuals who…
- Trial name
- NCT06597448
- Testing
- Cognitive Behavioral Therapy for Postpartum Depression (PPD)
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McMaster University
Depression During Pregnancy, Depression, Postpartum
IMAGINE: Pilot Trial of a Digital Group Intervention to Prevent Perinatal Depression
The goal of this clinical trial is to evaluate if a digital group intervention (named IMAGINE) can prevent depression in perinatal populations.
- Trial name
- NCT06746337
- Testing
- IMAGINE
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depression, Pregnancy Related
How Does Mindful Mood Balance for Moms Work?
The purpose of this investigation is to conduct a randomized trial comparing a web-based Mindful Mood Balance for Moms course without coaching support to waitlist control among pregnant or early parenting women with depression…
- Conditions
- Depression, Pregnancy Related, Antenatal Depression, Depression, Postpartum
- Trial name
- NCT05000879
- Testing
- MMB for Moms
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Boulder
Post-partum Hemorrhage
REBOA in Life-threatening Postpartum Hemorrhage (PPH) in Uganda
Background Maternal mortality rates in many low-income countries (LMICs) remain high. The most prominent cause is bleeding after birth, called postpartum haemorrhage (PPH).
- Trial name
- REBOA-PPH (NCT05598502)
- Testing
- REBOA, Resuscitative Endovascular Occlusion of the Aorta, National guidelines
- Where
- Uganda
- Volunteers
- 95 people
- Sponsor
- Centre For International Health
Post-Partum Hemorrhage
Fibrinogen in Haemorrhage of Delivery
The purpose of the study is to assess the benefits of a therapeutic strategy that associates an early administration of human fibrinogen concentrate in the management of PPH on the reduction of bleeding after the initiation of…
- Trial name
- FIDEL (NCT02155725)
- Testing
- Human Fibrinogen concentrate
- Where
- 31 sites in France, Martinique
- Volunteers
- 448 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Thromboembolism in the Puerperium
Safety of Fondaparinux as Post Partum Thromboprophylaxis
Venous thromboembolism (VTE) remains as one of leading causes of maternal morbidity and mortality, with postpartum period carries the greatest risk.
- Trial name
- NCT04447378
- Testing
- Fondaparinux 2.5Mg/0.5Ml Inj Syr
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Postoperative Pain, Postpartum Anxiety
Acupressure for Pain and Anxiety After Cesarean Section
The goal of this clinical trial is to evaluate whether acupressure combined with standard post-operative modern medical care can reduce pain and anxiety in postpartum women after cesarean delivery under spinal anesthesia.
- Conditions
- Postoperative Pain, Postpartum Anxiety, Acupressure
- Trial name
- NCT07805720
- Testing
- Acupressure, Standard care
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Postpartum Depression
A Study of BRII-297 in Healthy Adult Subjects
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics of BRII-297 in healthy adult subjects.
- Trial name
- NCT05845840
- Testing
- BRII-297
- Where
- Australia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brii Biosciences Limited
Post Partum Haemorrhage
Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial
The study aims at comparing the roles of carbetocin and oxytocin in the prevention of atonic PPH in women undergoing CS for placenta previa.
- Trial name
- NCT02303418
- Testing
- Carbetocin, Oxytocin
- Where
- 2 sites in Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Postpartum Depression
1-Day CBT Workshops for PPD
Postpartum depression (PPD) affects up to 20% of women and has profound effects on women and their families. Clinical practice guidelines recommend that the majority of women with PPD receive psychotherapy.
- Trial name
- NCT03654261
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 461 people
- Sponsor
- McMaster University
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe
Low-Sodium Diet for Postpartum Blood Pressure Control
The goal of this randomized controlled trial is to learn if a low-sodium diet improves postpartum blood pressure control in adults who were diagnosed with a late-onset hypertensive disorder of pregnancy.
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe, Pre-Eclampsia; Mild, Postpartum
- Trial name
- NCT07752056
- Testing
- Low Sodium Diet
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Stress Urinary Incontinence
MoVo-guided Traditional Chinese Kegel Exercises for Preventing Postpartum Urinary Incontinence.
The goal of this clinical trial is to determine whether a prenatal exercise program integrating Liuzijue qigong with traditional levator ani training, guided by the MoVo (Motivation-Volition) theory and delivered via a supervised…
- Trial name
- NCT07742202
- Testing
- Routine Verbal Instruction Group, App-Supervised Kegel Exercise Group, Liuzijue & Levator Ani Training Group
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Yu xin Qian
Post Partum Hemorrhage
Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage
The aim of the study is to evaluate the effect of oral tranexamic acid plus, sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH) after vaginal delivery
- Trial name
- NCT03870256
- Testing
- misoprostol, Carbetocin, TA
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
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