Clinical trials: Puerperal Disorder
Postpartum Depression
Quetiapine Versus Trazadone in Women With Postpartum Depression
Postpartum depression is a serious disorder that affects approximately 17% of women who have recently given birth. Untreated postpartum depression can negatively affect the mother, the infant, and the family.
- Trial name
- NCT06546358
- Testing
- Trazodone, Quetiapine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Uterine Atony, Uterine Tone Disorders
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections
Insufficient uterine tone resulting in atony can potentiate hemorrhage and adverse outcomes for the parturient. Oxytocin is the first pharmacologic agent used, followed by methylergonovine, carboprost, and misoprostol.
- Conditions
- Uterine Atony, Uterine Tone Disorders, Postpartum Hemorrhage
- Trial name
- NCT03303235
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Urinary Incontinence
Effectiveness of Foam RE and KE for Urinary Incontinence in Postpartum Women With Diastasis Recti
The objective of the study will be to assess the efficacy of foam rolling alone and combination treatment of foam rolling and Kegel exercises in alleviating urinary incontinence among postpartum women with diastasis recti.
- Trial name
- NCT07037160
- Testing
- Kegel exercises, Kegel exercises with Foam Rolling
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Postpartum Recovery, Mother-infant Bonding
Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery
This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery.
- Conditions
- Postpartum Recovery, Mother-infant Bonding, Labor Pain
- Trial name
- NCT07582289
- Testing
- Labor Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ataturk University
Tobacco Use Disorder
Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women
The purpose of this small preliminary study is to determine whether it is feasible to recruit women smokers who have just delivered a baby and are not breastfeeding into a study that would test whether starting bupropion, a…
- Trial name
- NCT00119210
- Testing
- Bupropion SR
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Placenta, Retained, Placenta; Retention, Fragments, Complicating Puerperium, Without Hemorrhage
Management of Large Retained Products of Conception (> 4 cm): Need for an Standardized Procedure.
Collection of relevant data form patients who were treated in the Ghent University Hospital in the context of a placental remnant lager than 4 cm, performing statistical analyzes on the collected data, reviewing the literature on…
- Conditions
- Placenta, Retained, Placenta; Retention, Fragments, Complicating Puerperium, Without Hemorrhage, Placenta; Retention, Fragments, Complicating Puerperium (Delayed Hemorrhage), Pregnancy Related
- Trial name
- NCT04720885
- Testing
- kind of surgery
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Postpartum, Postpartum Depression (PPD)
Postpartum Care in the NICU Multi-Site
Parents of infants admitted to the neonatal intensive care unit (NICU) face unique challenges in caring for their own health after giving birth.
- Conditions
- Postpartum, Postpartum Depression (PPD), Hypertension Disorders in Pregnancy, Postpartum Anxiety
- Trial name
- PeliCaN (NCT07873190)
- Testing
- Postpartum Doula Support in the NICU
- Where
- 14 sites in United States
- Volunteers
- 756 people
- Sponsor
- Children's Hospital of Philadelphia
Postpartum Depression
RE104 Safety and Efficacy Study in Postpartum Depression
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms in participants with moderate-to-severe postpartum depression (PPD) as compared to active-control.
- Trial name
- NCT06342310
- Testing
- RE104 for Injection
- Where
- 38 sites in United States
- Volunteers
- 84 people
- Sponsor
- Reunion Neuroscience Inc
Postpartum Hemorrhage
Temporary Aortic Compression With the Abdominal Tourniquet for Refractory Postpartum Hemorrhage
This multicenter study aims to evaluate effectiveness and safety of using the AAJT-S device as a temporary intervention for severe, atony-related PPH that is refractory to standard therapies
- Trial name
- ACT-PPH (NCT07034924)
- Testing
- Abdominal Aortic and Junctional Tourniquet - Stabilized (AAJT-S)
- Where
- Ukraine
- Volunteers
- 20 people
- Sponsor
- LLC UkrMedGroup
Venous Thromboembolism (VTE), Post Partum Women
Prevention of Postpartum Venous Thromboembolism in Women at Intermediate Risk
Venous thromboembolism (VTE) is currently the second cause of death in women of reproductive age worldwide. The incidence of VTE during pregnancy is 1.2 to 1.4/1000 women, half of VTE occurring during postpartum and as PE in…
- Trial name
- MUM-VTE (NCT06845423)
- Testing
- Low molecular weight heparin
- Where
- 18 sites in France
- Volunteers
- 2,400 people
- Sponsor
- University Hospital, Brest
Hypertension, Pregnancy Induced
Better Understanding Patient Perspectives of an Educational Tool for Postpartum Hypertensive Patients
The goal of this clinical trial is to learn if an educational tool helps postpartum patients after having high blood pressure during their pregnancy.
- Trial name
- NCT06996496
- Testing
- Postpartum educational tool after hypertensive pregnancy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Influenza, Vaccine
Influenza Vaccine Postpartum Questionnaire
The purpose of this trial is to assess the knowledge and attitudes of post-partum women regarding influenza and the use of the influenza vaccine in pregnancy.
- Conditions
- Influenza, Vaccine, Pregnancy
- Trial name
- NCT00401700
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Body Image, Urinary Incontinence
Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual Function
The first objective to determinate the prevalence of pelvic floor dysfunction in pregnant women and in the first year postpartum.
- Conditions
- Body Image, Urinary Incontinence, Anal Incontinence, Anorectal Disorder
- Trial name
- PFD-BI (NCT03591393)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Misoprostol Allergy
Pre Versus Post-operative Misoprostol in Reducing Blood Loss After Cesarean Section
Cesarean section is the most common performed major surgical interventions among women all over the world.Cesarean section has many serious complications, including primary postpartum hemorrhage (PPH).
- Trial name
- NCT05928871
- Testing
- Misoprostol 200mcg Tab, Misoprostol Pill
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Insufficient Lactation
Improving Lactation Success in Black Mothers of Critically Ill Infants
Racial disparities result in Black infants in the neonatal intensive care unit (NICU) receiving less breast milk (BM) than White and Hispanic infants.1 BM improves infant health yet mothers of critically ill infants produce…
- Trial name
- NCT05147987
- Testing
- Hands free wearable breast pump
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Post-partum Depression
Preventing Postpartum Depression in Prenatal Care
This is randomized control trial of a brief intervention called Bellevue ROSE (Reach Out Stay Strong Essentials). Bellevue ROSE is a manualized and highly structured interpersonal intervention that provides women with…
- Trial name
- NCT02741206
- Testing
- Bellevue ROSE Intervention, Psycho-education session and usual, Standard of care Control, One Psycho-education session and usual, standard of care Control
- Where
- United States
- Sponsor
- NYU Langone Health
Premature Birth
Exploring the Feasibility of Centering Pregnancy With Care Navigation
Pacific Islanders residing in the United States (US) have disproportionally high rates of preterm birth (<37 weeks) and low birthweight infants (<2,500 grams).
- Trial name
- NCT05645549
- Testing
- Centering Pregnancy with Care Navigation
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Bipolar Disorder
Pregnant Women Taking Lamictal for Bipolar Disorder
This study seeks to examine how the dose of lamotrigine (Lamictal) should be adjusted during pregnancy for women with Bipolar Disorder.
- Trial name
- PK-LAPB (NCT01996293)
- Testing
- lamotrigine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Cardiovascular Health
HERE: Health Empowerment and Resources After Pregnancy
This study will examine whether a patient navigation program can help improve long-term heart health among people who experienced high blood pressure disorders during pregnancy at Boston Medical Center (BMC).
- Trial name
- HERE (NCT07701148)
- Testing
- Longitudinal patient navigation, Standard care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Medical Center
Depression, Postpartum, Postpartum Depression
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD).
- Conditions
- Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression
- Trial name
- NuMom (NCT06285916)
- Testing
- NORA520 Dose 1, NORA520 Dose 2
- Where
- 18 sites in United States
- Volunteers
- 93 people
- Sponsor
- TWi Biotechnology, Inc.
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