Clinical trials: Puerperal Disorder
Premature Birth, Theory, Double Bind
The Meleis Theory on Postpartum Depression, Breastfeeding, and Maternal Self-Efficacy in Women Experiencing Preterm Birth
The aim of this study was to evaluate the effect of a nursing approach based on Meleis' Transition Theory on postpartum depression, maternal self-efficacy and breastfeeding self-efficacy in women who gave birth preterm.
- Conditions
- Premature Birth, Theory, Double Bind, Postpartum Depression, Breast Feeding
- Trial name
- NCT06250933
- Testing
- Postpartum Maternal Care and Premature Infant Care Training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Postpartum Hemorrhage
Carbetocin Versus Ergometrin in the Prevention of Postpartum Hemorrhage
In the present study will be compared Carbetocin with ergometrin in the prevention of postpartum haemorrhage (PPH) in parturients that are undergoing caesarean section and are not presenting risk factors for PPH.
- Trial name
- NCT04300452
- Testing
- Carbetocin, Ergometrine Maleate
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Nipple Discharge
Microdochectomy for Chronic Non Dilated Single Duct Nipple Discharge
The goal of this clinical trial is to evaluate the efficacy of a new technique in treatment of single milk duct discharge. The main questions it aims to answer are: Does ultrasound guided microdochectomy is feasible in non…
- Trial name
- NCT07305558
- Testing
- ultrasound guided microdochectomy
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Zagazig University
Post Partum Depression
ROSE in Sunset Park
The purpose of this study is to learn more about pregnant women's' experience with Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) and to evaluate the effectiveness of the ROSE program in preventing and reducing…
- Trial name
- NCT04940585
- Testing
- ROSE Program
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Gestational Diabetes
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in…
- Trial name
- NCT05917587
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Virtual Reality, Postpartum Depression (PPD)
Virtual Reality-Assisted Intraoperative Sensory Modulation on Postpartum Depression and the Kynurenine Pathway
The research will be conducted as a prospective, observational, and comparative study with 98 pregnant volunteers aged 18-45 at Düzce University Faculty of Medicine.
- Conditions
- Virtual Reality, Postpartum Depression (PPD), Kynurenine Pathway and Its Metabolites, Pregnancy
- Trial name
- VR effect (NCT07300176)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Duzce University
Postpartum Depression
Ketamine to Prevent PPD After Cesarean
The investigators plan to randomise participants to receive ketamine or placebo control subcutaneously or by 40-minute intravenous infusions and will follow them up for 42 days to assess the incidence of postpartum depression.
- Trial name
- PoCKet (NCT04227704)
- Testing
- Ketamine 50 MG/ML, Control
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Overweight, Obese
Post-delivery Maternal-offspring Obesity and Metabolic Risk After a Prepregnancy Weight-loss Intervention
The goal of PrepareD is to examine whether the prepregnancy weight-loss intervention administered during the Prepare trial [NCT02346162] has an influence in the postnatal period.
- Conditions
- Overweight, Obese, Metabolic Disorders, Postpartum
- Trial name
- PrepareD (NCT06067126)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Kaiser Permanente
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Severe Preeclampsia, Postpartum Hemorrhage
Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia
Postpartum hemorrhage is an important cause of maternal morbidity and mortality. In patients with severe preeclampsia there is an increased risk of postpartum hemorrhage but the hemodynamic changes associated with this pathology…
- Trial name
- NCT01382732
- Testing
- Carbetocin, Oxytocin
- Where
- Panama
- Volunteers
- 636 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
Post-Pregnancy Cardio Trial
Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and…
- Trial name
- PPC1 (NCT03313063)
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Postpartum Hemorrhage
A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects
Carbetocin is an oxytocin receptor agonist that selectively binds to receptors in the smooth muscle of the uterus, stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions, and raises the…
- Trial name
- NCT05924321
- Testing
- Carbetocin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Hyperbilirubinemia, Jaundice
Improving Health Outcomes for New Mothers and Babies
Because adherence to postnatal care guidelines across the United States (U.S.) is poor, newborns and mothers often are placed at undue risk for adverse medical and social outcomes.
- Conditions
- Hyperbilirubinemia, Jaundice, Dehydration, Postpartum Depression
- Trial name
- NCT00360204
- Testing
- Home Nurse Visit
- Where
- 2 sites in United States
- Volunteers
- 1,154 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pre-Eclampsia, Gestational Hypertension
Neonatal Sleep Intervention to Improve Postpartum Hypertension
The investigators are conducting a single center, randomized controlled trial testing the impact of a neonatal sleep intervention, the SNOO, on reducing maternal blood pressure (BP) in the postpartum period in women with…
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Sleep
- Trial name
- NCT04864249
- Testing
- SNOO, Safe sleep education in the postpartum period
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Alisse Hauspurg
Prenatal Depression, Ketamine
Low-dose S-ketamine in Women With Prenatal Depression
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT04414943
- Testing
- S-ketamine
- Where
- 7 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital
Depression, Postpartum, Depression, Unipolar
Tracking Depression Symptoms With a Health Chatbot
The goal of this research is to bridge a significant "effectiveness" gap in the treatment of depression. The investigators have developed a chatbot which will assist in performing measurement-based care (MBC) via Facebook…
- Trial name
- NCT03990389
- Testing
- Chatbot Intervention
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Postpartum Depression, Postpartum Anxiety
The SUPPORT Study: Effectiveness and Usability of a Web-Enabled Resource for Postpartum Mental Health
The SUPPORT Study aims to evaluate the effectiveness and usability of postpartumcare.ca, a web-enabled resource for postpartum depression (PPD) and postpartum anxiety (PPA), created based on the input of birthing parents in…
- Conditions
- Postpartum Depression, Postpartum Anxiety, Postnatal Depression, Perinatal Disorder
- Trial name
- SUPPORT (NCT05382884)
- Testing
- Postpartumcare.ca (Web-Enabled Intervention)
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- University of British Columbia
Post Partum Depression
Effect of a Cooperative Education Program Based on Precede-Proceed Model During Pregnancy on Postpartum Depression
This trail aims to evaluate the effects of a cooperative education program based on precede-proceed model during pregnancy on preventing postpartum depression in southern Razavi Khorasan Province.
- Trial name
- NCT04129476
- Testing
- Cooperative Education Program based on Precede-Proceed Model
- Where
- Iran
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gonabad University of Medical Sciences
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Post Partum Hemorrhage
Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery.
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality. Globally, it is responsible for 25% of all pregnancy-related deaths. PPH is unpredictable and may occur in the absence of risk factors.
- Trial name
- NCT06604325
- Testing
- Tranexamic acid injection
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Aligarh Muslim University
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