Clinical trials: Pulmonary
COPD
Replication of the IMPACT COPD Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT05062304
- Testing
- Fluticasone Furoate-Vilanterol Trifenatate, Furoate-umeclidinium-vilanterol
- Where
- United States
- Volunteers
- 17,281 people
- Sponsor
- Brigham and Women's Hospital
Lung Cancer
Almonertinib as First-line Treatment in Patients With EGFR Mutations Positive in Advanced NSCLC With Brain Metastases
This is a prospective, open-label, multi-center, single-arm clinical trial
- Trial name
- ACHIEVE (NCT04808752)
- Testing
- Almonertinib
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Zhejiang Cancer Hospital
Non-small Cell Lung Cancer
Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI
This study is a randomized phase III trial that aiming to investigate the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) guided hypofractionated radiotherapy (hypo-RT) in patients with locally advanced…
- Trial name
- NCT06545747
- Testing
- DCE-MRI based split-course hypo-RT, CT based split-course hypo-RT, Concurrent chemotherapy
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Sun Yat-sen University
Emphysema
Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of pulmonary vascular dilatation to characterize…
- Trial name
- NCT02682147
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Eric A. Hoffman
Non-Small Cell Lung Cancer, Small Cell Lung Cancer
SYS6090 Combination Therapy in Advanced Lung Cancer
This is an open-label, multi-cohort, multicenter Phase Ib/II clinical study designed to evaluate the safety, tolerability, and efficacy of SYS6090 injection in combination with chemotherapy or chemotherapy and bevacizumab or…
- Trial name
- NCT07472647
- Testing
- SYS6090 + pemetrexed + platinum-based chemotherapy, SYS6090 + paclitaxel + platinum-based chemotherapy, SYS6090 + docetaxel
- Volunteers
- 596 people
- Sponsor
- Shanghai JMT-Bio Inc.
Asthma
Dose Finding Study of Albuterol Sulfate in Patients With Intermittent or Persistent Mild Asthma
The drug product albuterol sulfate DPI, TBS-7, is a single dose inhalation product of albuterol sulfate containing 240 ug albuterol sulphate (200 ug of albuterol) and inhalation grade lactose in a new dry powder delivery system…
- Trial name
- NCT01252758
- Testing
- albuterol sufate DPI (TBS-7) dose 1, albuterol sufate DPI (TBS-7) dose 2, albuterol sufate DPI (TBS-7) dose 3
- Sponsor
- Acerus Pharmaceuticals Corporation
End Stage Liver Diseases
Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury.
- Trial name
- SPPLIT (NCT02119585)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Local Advanced Non-Small Cell Lung Cancer
Study of Concurrent Pemetrexed, Cisplatin and Radiotherapy in Local Advanced Non-Small Cell Lung Cancer
The purpose of this study is to determine the recommended dose of pemetrexed and the maximum tolerated dose of radiotherapy when using concurrent pemetrexed/cisplatin/radiotherapy in the patients with local advanced non-small…
- Trial name
- NCT00846443
- Testing
- Concurrent Pemetrexed, Cisplatin and Radiotherapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Fudan University
Cough Variant Asthma
Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules.
This single-center, randomized, double-blind, placebo-controlled trial was undertaken at an outpatient clinic in Shuguang Hospital. Newly diagnosed cough variant asthma adult patients with the T.C.M.
- Trial name
- NCT03319043
- Testing
- Chanqin granules
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Breast Cancer, Lung Cancer
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation
Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma
- Trial name
- OCTANE (NCT02906943)
- Where
- 7 sites in Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Acute Myocardial Infarction, Heart Failure
Prognostic Value of Lung Ultrasound in ST Segment Elevation Acute Myocardial Infarction (LUS-AMI)
The purpose of this study is to asses the prognostic value of lung ultrasound in patients with ST-segment elevation acute myocardial infarction.
- Trial name
- LUS-AMI (NCT04526535)
- Testing
- Lung ultrasound
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
COVID-19, COVID
Pegylated Interferon Lambda Treatment for COVID-19
Prospective randomized trial to assess the antiviral efficacy of Pegylated Interferon Lambda (180 mcg SC injection) vs.placebo in up to 20 subjects with COVID-19 infection.
- Trial name
- NCT04343976
- Testing
- Pegylated interferon lambda
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Raymond Chung
Locally Advanced Non Small Cell Lung Cancer (NSCLC)
Cilengitide Together With Radiochemotherapy in Patients With Locally Advanced Non Small Cell Lung Cancer
This is a two-center study which includes 24 patients maximum on 36 months : 24 months accrual - 12 months follow up. Eligible patients are included according to a standard 3+3 design.
- Trial name
- NCT01118676
- Testing
- cilengitide, radiochemotherapy
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Institut Claudius Regaud
Chronic Obstructive Pulmonary Disease (COPD)
A Pragmatic Cluster Trial of a Tailored Intervention to Improve COPD Management
Background: Chronic Obstructive Pulmonary Disease (COPD) remains a major health problem, which is strongly related to smoking. Despite publication of guidelines on the prevention and treatment of COPD, not all COPD patients…
- Trial name
- TICD-COPD (NCT01893476)
- Testing
- Implementation educational programme
- Where
- Poland
- Volunteers
- 540 people
- Sponsor
- Medical University of Lodz
Tumors Characterized by Genetic Abnormalities of ALK
A Dose Escalation/Expansion Study of LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase
This study assessed the safety and efficacy of LDK378 in adult patients with genetic abnormalities in anaplastic lymphoma kinase (ALK).
- Trial name
- NCT01283516
- Testing
- LDK378
- Where
- 21 sites in United States, Australia and 9 more
- Volunteers
- 304 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
This is a Non-interventional, Study to Assess Demographic Characteristics and Patient Reported Outcomes in China Patients With SEA Treated With Benralizumab
The objective of this study is to collect empirical data that elucidates the clinical profile and therapeutic efficacy of benralizumab among the patients aged 12 years and above, with severe eosinophilic asthma.
- Trial name
- SPEED (NCT06862206)
- Testing
- benralizumab
- Where
- 36 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Safety, Tolerability, and Pharmacodynamic Effect Study of PUR118
The purpose of this study is to establish single and multiple dose safety in healthy subjects and subjects with mild chronic pulmonary obstructive disease (COPD).
- Trial name
- NCT01333904
- Testing
- PUR118
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pulmatrix Inc.
Pulmonary Atelectasis, Bariatric Surgery
The Incidence of Post-Operative Lung Atelectasis With Erector Spinae Plane Block in Bariatric Surgery:
We aim to compare the incidence of post-operative lung atelectasis with erector spinae plane block versus systemic analgesia in patients undergoing bariatric surgery
- Trial name
- NCT06695858
- Testing
- ESPB
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Kasr El Aini Hospital
Alpha 1-Antitrypsin Deficiency
A Study of Belcesiran in Patients With AATLD
This is a multiple dose, randomized, placebo-controlled, double-blind study of belcesiran to evaluate the safety, tolerability, PK, and PD in adult patients with PiZZ AATD-associated liver disease (AATLD).
- Trial name
- ESTRELLA (NCT04764448)
- Testing
- Belcesiran
- Where
- 23 sites in United States, Australia and 12 more
- Volunteers
- 16 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Shock
The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Shock is a common condition in critical care unit (ICU). It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock.
- Trial name
- NCT03082326
- Where
- China
- Volunteers
- 181 people
- Sponsor
- West China Hospital